Paracoccidioidomycosis: Report of 2 cases mimicking squamous cell carcinoma

Meneses-García, Abelardo; Mosqueda‐Taylor, Adalberto; Luz, Rosario Morales-de la; Rivera, Luz María Ruíz‐Godoy

doi:10.1067/moe.2002.129179

Cited by 30 publications

(21 citation statements)

References 8 publications

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“…Other 23 single reports or series reports, one from Mexico, one from Argentina, and the others from Brazil, only described cases presenting malignancy and mycosis without references to the total number of patients observed in these cohorts of paracoccidioidomycosis [28][29][30][31][32][33][34][35][36][37][38]. One case of lung carcinoma, one of them in a patient receiving chemotherapy (oat cell carcinoma) and presenting Strongyloides stercoralis in the sputum, whose pulmonary biopsy showed oat cell carcinoma and the necropsy, large necrotic areas and bizarre forms of the fungi [28].…”

Section: Hematological and Solid Organ Malignanciesmentioning

confidence: 99%

“…Three more cancer cases presenting malignancy and mycotic lesions in the same organ (oral mucosa and in larynx) were described [36,38]. Squamous cell carcinoma of the lung was described in a patient with oral mycotic lesions, whose diagnosis was made lately after lack of improvement with antifungal treatment [37].…”

Section: Hematological and Solid Organ Malignanciesmentioning

confidence: 99%

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Neoplasia and paracoccidioidomycosis

et al. 2008

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Published studies on the association between cancer and paracoccidioidomycosis consist either isolated cases or clinical data based on hospital cohorts of paracoccidioidomycosis. The frequency of neoplasia in series of ! 80 patients with paracoccidioidomycosis ranges from 0.16 to 14.1%, mean of 3.96%. There are only two retrospective controlled studies, one of them showing greater incidence of carcinoma in biopsy and necropsy samples of paracoccidioidomycosis (12 cases in 147 patients with the mycosis: 8.2%) than in the necropsies of the control group (320 cases in 7,302 necropsies: 4.9%). In the other, 22,409 autopsies were reviewed and 4,372 cases of cancer were found; of the 85 patients with paracoccidioidomycosis, 12 were diagnosed with cancer. No differences were observed in the frequency of malignancies between the group of patients with paracoccidioidomycosis (14.1%) and the control group (19.5%). Considering all the reported cases, carcinoma was more frequent than hematological malignancies, and was more often found at the same site or in a neighboring site affected by the mycosis, usually occurring after the diagnosis of the mycosis. Commonly, the basic cause of death was related to secondary infections or neoplasia. Lymphoma was associated with poorly organized rich in fungi granuloma. The clinical course and mortality were related to the cancer evolution or secondary infections and was worse in lymphoid series, metastatic carcinoma or in patients under cytotoxic chemotherapy. Additionally, as in several cases the clinical and histopathological data

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Section: Hematological and Solid Organ Malignanciesmentioning

confidence: 99%

Section: Hematological and Solid Organ Malignanciesmentioning

confidence: 99%

Neoplasia and paracoccidioidomycosis

et al. 2008

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“…[1] PCM more commonly affects farm workers and/or people who live in rural areas, people between 30 and 50 years of age, particularly males. The disease is more prevalent in South and Central Americas, especially in regions with wet climate, high rainfall, and acid soils.…”

Section: Introductionmentioning

confidence: 99%

“…[14] Expectoration, cold, dyspnea, thoracic pain, fever, hemoptysis, anorexia, and weight loss are observed in most cases. [4] Oral lesions commonly affect gums, palate, and labial and buccal mucosae.…”

Section: Introductionmentioning

confidence: 99%

Disseminated paracoccidioidomycosis diagnosis based on oral lesions

et al. 2014

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Paracoccidioidomycosis (PCM) is a deep mycosis with primary lung manifestations that may present cutaneous and oral lesions. Oral lesions mimic other infectious diseases or even squamous cell carcinoma, clinically and microscopically. Sometimes, the dentist is the first to detect the disease, because lung lesions are asymptomatic, or even misdiagnosed. An unusual case of PCM with 5 months of evolution presenting pulmonary, oral, and cutaneous lesions that was diagnosed by the dentist based on oral lesions is presented and discussed.

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“…A striking feature of its epidemiology is its increased frequency in males, tobacco users, and restriction to people who have been in close contact with rainforests or agricultural regions 7) . The majority of case reports on PMC concern males, and there are few case reports available on PMC in females 9,[11][12][13][14]17,18,25,28) . In this case, the patient was a female smoker who had worked in an agricultural region 10 years prior to moving to a metropolitan region.…”

Section: Discussionmentioning

confidence: 99%

Case of Recurrent Paracoccidioidomycosis in Female 10 Years after Initial Treatment

Izidoro

Silva

Ribas

et al. 2007

Bull. Tokyo Dent. Coll.

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This report describes a case of recurrence of chronic paracoccidioidomycosis 10 years following the initial diagnosis. A 56-year-old female was admitted to the Dental Clinic of the Pontifical Catholic University of Paraná complaining of oral soreness. Mulberry-like ulcerations were observed on the gingiva, right labial comissura, and vermillion of the lip. The patient reported persistent chronic cough, weight loss, appetite loss and fever. The anamnesis revealed that the patient had developed and been treated for paracoccidioidomycosis 10 years earlier. A biopsy was performed and microscopic examination revealed microabscesses, collections of macrophages organized into granulomas, multinucleated giant cells and Paracoccidioides brasiliensis. The patient was treated with Itraconazole and, the oral lesions disappeared within 3 months. Persistent follow-up examination in patients with a history of paracoccidioidomycosis is essential in the management of this disease.

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Paracoccidioidomycosis: Report of 2 cases mimicking squamous cell carcinoma

Cited by 30 publications

References 8 publications

Neoplasia and paracoccidioidomycosis

Neoplasia and paracoccidioidomycosis

Disseminated paracoccidioidomycosis diagnosis based on oral lesions

Case of Recurrent Paracoccidioidomycosis in Female 10 Years after Initial Treatment

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