Paracoccidioidomycosis and tuberculosis in AIDS patients: Report of two cases in Brazil

Nogueira, Susie Andries; Caiuby, M. J.; Vasconcelos, Vânia; Halpern, Márcia; Gouveia, Carla Maria Barroso; Thorpe, Beatriz; Ramparini, Cristiani; Madeira, Juan M. Piñero; Lambert, John S.

doi:10.1016/s1201-9712(98)90122-9

Cited by 12 publications

(7 citation statements)

References 9 publications

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“…t ropism toward the monocytic-phagocytic system, as expressed by cervical or generalized infarction of the ganglions, hepatosplenomegaly, frequent cutaneous lesions, bone lesions, tendency to systemic dissemination and, eventually, association to tuberculosis. 35 The cutaneous manifestations can be atypical, as shown in figure 3. In the cases in which the CD4+ cell count was reported, it was observed that paracoccidioidomycosis is more frequent in patients with < 200 cells CD4+/mm 3 , characterizing pronounced states of immunosuppression.…”

Section: O L O G Y Notable Is the Re P O Rt Of Parinaud's Oculoglandmentioning

confidence: 99%

Paracoccidioidomicose: atualização epidemiológica, clínica e terapêutica

Marques

2003

An. Bras. Dermatol.

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São apresentados dados de atualização epidemiológica, clínica, diagnóstica e terapêutica relativos à paracoccidioidomicose. Discute-se a importância epidemiológica resultante do isolamento do Paracoccidioides brasiliensis a partir do tatu (Dasypus novemcinctus) em regiões do Brasil e Colômbia, assim como dos resultados de inquéritos soroepidemiológicos em cães e do surgimento do primeiro caso de paracoccidioidomicose doença em cão. As dificuldades de isolamento do fungo a partir do solo são correlacionadas com novos informes de investigação epidemiológica. São apresentados aspectos clínicos das manifestações da forma aguda da doença, assim como das manifestações da neuroparacoccidioidomicose e da enfermidade associada à infecção pelo HIV. Discute-se o papel da sorologia e da técnica da PCR no diagnóstico e dos possíveis avanços no tratamento da paracoccidioidomicose com os novos derivados triazólicos.

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Section: O L O G Y Notable Is the Re P O Rt Of Parinaud's Oculoglandmentioning

confidence: 99%

Paracoccidioidomicose: atualização epidemiológica, clínica e terapêutica

Marques

2003

An. Bras. Dermatol.

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“…[5][6][7] Many co-infected patients lived in the southeastern and west-central regions of Brazil, where this fungal disease is hyperendemic. Three series of 7, 10, and 12 patients, respectively, have been reported, 8-10 but other reports described only one or two cases of P. brasiliensis -human immunodeficiency virus (HIV) co-infection, in patients in Brazil [11][12][13] and in patients in other Latin American countries. 14 The first cases were reviewed in 1995.…”

Section: Introductionmentioning

confidence: 99%

Paracoccidioidomycosis in Patients Infected with and Not Infected with Human Immunodeficiency Virus: A Case-Control Study

Morejón

Machado

Martínez

2009

The American Journal of Tropical Medicine and Hygiene

110

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Epidemiologic and clinical data for 53 patients with paracoccidioidomycosis and co-infected with human immunodeficiency virus (HIV) (cases) were compared with those for 106 patients with endemic paracoccidioidomycosis (controls). The prevalence of Paracoccidioides brasiliensis co-infection was estimated in 1.4% in cases of acquired immunodeficiency syndrome (AIDS). Patients co-infected with HIV were younger, less involved in agricultural occupations; 83.7% had CD4+ cell count < 200 cells/microL. Paracoccidioidomycosis in co-infected patients usually showed a rapid progression, with more fever, frequent involvement of the lungs, and multiple extrapulmonary lesions. The response to antifungal therapy and deaths caused by paracoccidioidomycosis were similar in the two patient groups, but late relapses were more common in co-infected cases. Paracoccidioidomycosis in HIV-infected patients shows epidemiologic and clinical characteristics differing from those of the endemic disease and should be considered an AIDS-defining opportunistic infection in Latin America.

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“…Several reports emphasize the difficulties in diagnosis of PCM in AIDS patients [8]; PCM usually remains undiagnosed, especially in the presence of a concomitant disease with a similar clinical course such as tuberculosis, which is a frequent PCM coinfection [9]. Serology is not useful for diagnosis, despite reports ascribing use as prognostic index [10] Recently, polymerase chain reaction (PCR) techniques have been introduced for the detection of systemic fungal infections; and P brasiliensis nucleic acid direct PCR had high diagnostic sensitivity [11].…”

Section: Introductionmentioning

confidence: 99%