Paracetamol (Acetaminophen) Hypersensitivty

7 Cases of Anaphylaxis to Paracetamol

“…Literature review: We found other paracetamol anaphylaxis reported in the literature [5][6][7][8][9]. Skin tests are the principal way of diagnosis for an allergic reaction Ig-E mediated, like an anaphylaxis.…”

“…Stephenson, et al [21] reported that skin tests were not standardized and that it is very difficult to produce positive results with low-molecular-weight drugs. Few positive skin test results have been reported: Vidal, et al [5] described one case of anaphylaxis confirmed by OCT. Serum-specific IgE antibody to paracetamol was investigated with negative results. Galindo, et al [6] found a positive case of IDT at a concentration of 100 mg/ml in a patient with anaphylaxis.…”

“…However, hypersensitivity reactions to paracetamol are rare [1][2][3][4][5][6][7][8][9][10][11][12][13] (Figure 1). FIGURE 1: Paracetamol (acetaminophen, N-acetyl-para-amino- 1 1 phenol)…”

“…Although potentially IgE-mediated allergy to paracetamol has been reported [1][2][3][4][5][6][7][8][9][10], diagnosis is based on non-standardized in vivo and in vitro tests with unknown sensitivity and specificity, and in most cases, can only be confirmed using a single-blind oral challenge test (OCT) entails risks for patients.…”

Histamine in Beer

“…(Gutgesell and Fuchs, 1995;Vidal and González-Quintela, 1995 ;Santucci et al ., 1996 ;Bonadonna et al ., 1999 ;Curioni et al ., 1999 ) The fi rst identifi cation of allergens in malt and barley was achieved by Figueredo and co-workers in clinical and immunological studies carried out in a patient in whom anaphylaxis developed after drinking beer ( Figueredo et al ., 1999 ). (Gutgesell and Fuchs, 1995;Vidal and González-Quintela, 1995 ;Santucci et al ., 1996 ;Bonadonna et al ., 1999 ;Curioni et al ., 1999 ) The fi rst identifi cation of allergens in malt and barley was achieved by Figueredo and co-workers in clinical and immunological studies carried out in a patient in whom anaphylaxis developed after drinking beer ( Figueredo et al ., 1999 ).…”