Papular fixed drug eruption mimicking folliculitis due to acetaminophen

Fixed drug eruption (FDE): changing scenario of incriminating drugs

“…recorded FDE exclusively localized to site of bacillus Calmette–Guérin (BCG) vaccination. This interesting localization and predilection for certain sites has been recorded by several workers 71–77 . The interval between the original trauma and the initial onset of FDE lesions may range up to several years and may represent a form of recall phenomenon 69 .…”

“…The clinical expression of classic FDE is sufficiently distinctive to form a diagnosis (see above); however, the unusual expression of FDE may be overlooked unless there is a high degree of suspicion 71–77 . There are reports of localized bullous pemphigoid resembling bullous FDE, 212 or FDE masquerading as herpes (simplex) labialis 213 or discoid lupus erythematosus 214 .…”

Annular fixed drug eruption

“…This unique clinical feature prompted us to review the literature concerning the rare forms of FDE. Atypical FDE varies considerably, from poorly‐defined margins, erythema multiforme‐like, toxic epidermal necrolysis‐like, non‐pigmented, giant, urticarial, papular, purpuric, linear, and reticular to butterfly‐like lesions [2–6]. Occasionally it may mimic lichen planus, paronychia, cheilitis, herpes simplex and psoriasis [7, 8].…”

“…pigmentierte, gigantische, urtikarielle, papulöse, juckende, lineare und retikuläre Läsionen beschrieben [2][3][4][5][6]. Gelegentlich kann die fixe Arzneireaktion einen Lichen planus, Paronychien, Cheilitiden, einen Herpes simplex und eine Psoriasis imitieren [7,8].…”

Fixed drug urticaria: A report of two patients

“…1e3 Nevertheless, other clinical variants have been described, including dermatographic 4 or papular eruptions. 5 Either local anesthetics (LA) 6 or non-steroidal anti-inflammatory drugs (NSAIDS) 7 represent two major families of drugs causing FDE.…”