Papova Virus Group

Melnick, Joseph L.

doi:10.1126/science.135.3509.1128

Cited by 178 publications

(41 citation statements)

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“…This human wart virus is classified in the PAPOVA group (Melnick, 1962) along with other small DNA-containing oncogenic viruses. Much useful knowledge of the role of viruses in neoplastic processes has come from study of two animal viruses, SV 40 and polyoma, also members of the papova group.…”

Section: Introductionmentioning

confidence: 99%

Serological studies with human papova (wart) virus

Ogilvie

1970

J. Hyg.

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SUMMARYMethods for demonstrating antibody to wart virus by complement fixation and passive haemagglutination tests are described and compared with the precipitin test of Almeida & Goffe (1965). The results reveal the much greater sensitivity of the passive haemagglutination method, particularly in the detection of the immunoglobulin M class of antibody. Both complement-fixing and precipitating antibody were detected in sera from patients whose warts had undergone a spontaneous resolution.The presence of antibody to wart virus was demonstrated in sera from persons who had had warts up to 10 years previously, and in a few cases from those who thought they had never had warts.The antigenic identity of virus from hand warts and plantar warts of the simple and mosaic types was revealed, and some evidence was obtained for similar identity of the virus from genital warts.

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Section: Introductionmentioning

confidence: 99%

Serological studies with human papova (wart) virus

Ogilvie

1970

J. Hyg.

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“…Human papillomavirus (HPV) is a small, nonenveloped and double stranded circular DNA virus, about 8,000 bp in length, with a well-known physical structure and gene organization (1). HPV belongs in the subfamily papillomavirus (PV) of the papovavirus family, which are widely distributed in nature and infect many higher vertebrates including cattle, rabbits and dogs (1).…”

Section: Introductionmentioning

confidence: 99%

“…HPV belongs in the subfamily papillomavirus (PV) of the papovavirus family, which are widely distributed in nature and infect many higher vertebrates including cattle, rabbits and dogs (1). It is thought that the viruses may have co-evolved with their hosts (2).…”

Section: Introductionmentioning

confidence: 99%

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Human Papillomavirus in the Oral Cavity

Terai

Takagi

2001

Oral Med Pathol

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Human papillomavirus (HPV) cannot be efficiently propagated in tissue cultures or animal models. However, molecular biological technology has made it possible to clone viral genomes, which can then be compared and also used as reagents in clinical and epidemiological studies.Today HPV infections are recognized as being responsible for inducing cancers worldwide and it is expected that HPV-based technologies will provide the tools to prevent and treat HPV-induced cancers. In this review, we focus on the association between oral lesions and HPV infection and the natural history of HPV infection of the oral cavity. We also evaluate the HPV detection methods in this important and fundamental matter for the HPV studies. We then discuss the potential targeted molecular therapies and prevention of a variety of HPVinduced diseases of the oral cavity, including oral cancers. Key words: HPV, human papillomavirus, oral cavityCorrespondence : Minoru Takagi, Molecular Pathology, Oral Restitution, Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113- 8549, JapanPhone: +81-3-5803-5451, Fax: +81-3-5803-0188 IntroductionHuman papillomavirus (HPV) is a small, nonenveloped and double stranded circular DNA virus, about 8,000 bp in length, with a well-known physical structure and gene organization (1). HPV belongs in the subfamily papillomavirus (PV) of the papovavirus family, which are widely distributed in nature and infect many higher vertebrates including cattle, rabbits and dogs (1). It is thought that the viruses may have co-evolved with their hosts (2). They are highly species-specific species, having one or more of its own PVs, and viruses of one species do not infect other species (1).HPV is classified into more than 100 types, including 84 clones and others detected by PCR (3). To be recognized as a distinct HPV genome, the full genome should be cloned and the sequence of the L1 gene should be no more than 90% similar to previously assigned and referenced HPVs (4). HPVs naturally fall into two groups: mucosal HPVs and cutaneous HPVs according to the anatomic site of infection and/or phylogenetic analysis (5). Some HPV infections can lead to malignant lesions depending on HPV genotypes and infection persistence. HPV is also broadly categorized into low, intermediate and highrisk types in accordance with their potential to induce or their association with malignant lesions (6). In oral lesions 24 genotypes have been identified 2,3,4,6,7,10,11,13,16,18,30,31,32,33,35,45,52,55,57,59,69,72 and 73) (7-27) ( Table 1).The HPV genome is comprised of early (E) genes that function primarily in episomal replication and late (L) genes that encode the viral capsid proteins. HPV 16 genome map is shown in Fig. 1. The L1 and L2 genes code for proteins that make up the viral major and minor capsid. The capsid encloses the viral genome and mediates viral entry into susceptible cells (28). Much of the immune response to infection is directed at the capsid protein (29). Based on experi...

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“…In the following decades a number of major breakthroughs in many aspects of warts research have occurred as the appearance of HPV particles in skin warts [22], the concept of koilocytosis in Pap smears and cervical biopsies [23], the discovery of human papova group [24,25], the electron microscopic demonstration of HPV particles in genital warts [26,27], the description of koilocytic atypia as a sign of HPV in flat lesions of the cervix [28,29] and finally the leading discovery of the German virologist Herald zur Hausen (1936-). In 1976, he published the hypothesis that human papilloma virus plays an important role in the cause of cervical cancer [30] and then in 1983 he identified the types HPV16 and HPV18 [31].…”

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confidence: 99%