Serological studies with human papova (wart) virus

Ogilvie, Marie M.

doi:10.1017/s0022172400042388

Cited by 55 publications

(24 citation statements)

References 24 publications

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“…Earlier studies had demonstrated virus-specific antibodies in the sera of genital wart patients. 20 However, Almeida et al 21 had demonstrated that sera from genital wart patients specifically reacted with virus from genital warts only and not with that from skin warts unlike sera from skin wart patients which reacted with both types of viruses.…”

Section: Discussionmentioning

confidence: 98%

Immune Response Profiling of Patients with Anogenital Warts

Singh¹,

Thakral²,

Kar³

et al. 2017

Indian Journal of Medical Biochemistry

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The incidence of anogenital warts, commonly caused by human papillomavirus (HPV-6 and HPV-11), is increasing worldwide. These infections are frequently associated with relapse, possibly due to weak host immunity. However, the role of cell-mediated immune players in combating infection is not clearly understood till date. Here, we attempted to understand the immune profile among patients with anogenital warts. In this study, we compared the T-helper cell (Th1 and Th2) response in patients with venereal warts due to HPV-6 and HPV-11 infection relative to healthy controls (HCs) in vitro. In the in vitro model, the peripheral blood mononuclear cells were stimulated with HPV peptide 6 or 11, stained for T-cell surface marker and intracellular cytokines (interferon [IFN]-□ and interleukin [IL]-4), and were analyzed by flow cytometry. In the present study, significant decrease was observed in the frequency of IFN-□ T cells as compared with HCs. On the contrary, frequency of T cells expressing IL-4 was significantly increased in the patients. The observed functional skewing of HPV-specific T cells from Th1 to Th2 response in patients indicated suppressed immunity against the HPVs. Findings of our study have potential in the near future for strategizing adjunct immunomodulation approaches with the standard treatment for early remission and prevention of recurrence. How to cite this article Singh M, Thakral D, Kar HK, Rishi N, Mitra DK. Immune Response Profiling of Patients with Anogenital Warts. Indian J Med Biochem 2017;21(1):11-16.

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Section: Discussionmentioning

confidence: 98%

Immune Response Profiling of Patients with Anogenital Warts

Singh¹,

Thakral²,

Kar³

et al. 2017

Indian Journal of Medical Biochemistry

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“…A further nine out of ten showed antibody during the period 1-2 years after infection, giving a total figure of 708 % in the first two years. Although Ogilvie (1970a) showed precipitating antibody to be present in all of seven patients tested 3 months to 2 years after cure, Bunney et al (1971), in a controlled treatment trial, found that only 705 % (24 out of 34) patients whose warts were cured within a 12-week period showed an antibody response at the time of cure. The present survey has shown in addition that the percentage of people continuing to display antibody remained fairly high for 8-9 years, particularly following plantar wart infection.…”

Section: Discussionmentioning

confidence: 97%

“…Several tests for the detection of circulating antibody to human papilloma virus have already been described (Almeida & Goffe, 1965;Ogilvie, 1970a). The passive haemagglutination test of Ogilvie is a sensitive method, particularly for the detection of antibodies of the IgM class.…”

Section: Introductionmentioning

confidence: 99%

“…It is, however, fairly laborious, technical details are important and there is as yet the difficulty of establishing a base-line for significant titres. This is demonstrated by the fact that 21 out of 34 (61.8 %) of girls professing never to have had warts showed titres ranging from 20 to 320; nine of these girls with titres of 80 or above were considered to have significant antibody titres (Ogilvie, 1970a). The direct agglutination test described by Almeida and Goffe is relatively extravagant in mateiials, and the formation of precipitin lines in agar gel diffusion is a rather insensitive method.…”

Section: Introductionmentioning

confidence: 99%

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Serological studies in a student population prone to infection with human papilloma virus

Cubie

1972

Epidemiol. Infect.

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SUMMARYFour hundred and sixty-seven serum specimens from the female students at a residential college were examined for the presence of circulating antibody to human wart virus using the technique of counter-current immunoelectroosmophoresis. A significantly higher incidence of antibodies was found in students with a past history of plantar warts than in any other group. Antibody took several months to develop and was detectable in 20-30 % of the students up to 9 years after infection. From a few cases of multiple infection, it was shown that reinfection could occur in spite of the presence of circulating antibodies probably of the IgG class. The sensitivity of the test was compared with two recognized techniques for detection of wart virus antibodies, namely gel diffusion and passive haemagglutination.

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“…It has been used with non-specific antigen in previous studies of antibody prevalence to papilloma virus (Matthews & Shirodaria, 1973). IgM has been shown to be the predominant antibody associated with papilloma virus infection (Almedia, Goffe & Brown, 1966;Ogilvie, 1970) IgG antibody to human papilloma virus is usually found in conjunction with IgM and rarely in isolation. The prolongation of IgM response has been observed well beyond the usual 2-month period post infection (Shirodaria & Matthews, 1975).…”

Section: Introductionmentioning

confidence: 99%

A study of HPV 1, 2 and 4 antibody prevalence in patients presenting for treatment with cutaneous warts to general practitioners in N. Ireland

et al. 1988

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StJMMARYThree hundred and seventy-six patients attending their general practitioner with cutaneous warts at five health centres in Northern Ireland were screened for human papilloma virus (HPV) types 1 and 2 IgM antibody using an indirect immunofluorescence test. Eighty-eight (23-4 %) patients were positive for HPV type 1 IgM and 156 (41P5 %) for HPV type 2 IgM. HPV 1 IgM antibody was significantly more likely to be associated with plantar warts than warts elsewhere (P < 0-0001). HPV 2 IgM was present in 45 (341 %) patients with plantar warts and 99 (45f6 %) patients with warts at other sites (P = 041). Evidence of multiple infection by HPV types 1 and 2 was demonstrated by the finding of HPV 1 and 2 IgM antibodies in the sera of 16 (4-3 %). HPV 4 was found in only 1 out of 30 biopsies and HPV 4 IgM was undetectable in 50 randomly chosen sera.

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Serological studies with human papova (wart) virus

Cited by 55 publications

References 24 publications

Immune Response Profiling of Patients with Anogenital Warts

Immune Response Profiling of Patients with Anogenital Warts

Serological studies in a student population prone to infection with human papilloma virus

A study of HPV 1, 2 and 4 antibody prevalence in patients presenting for treatment with cutaneous warts to general practitioners in N. Ireland

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