Papillomavirus infection and cervical intraepithelial neoplasia: A study of male sexual partners

Levine, Richard U.; Crum, CP; Herman, Eugene H.; Rm, Richart

doi:10.1016/0090-8258(84)90116-1

Cited by 35 publications

(58 citation statements)

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“…In 1979, epidemiological evidence had already suggested a correlation between some male penile cancers and female partner cervical carcinomas [19]. A few years later there was proof that male sexual partners of women with various benign or premalignant cervical lesions were at high risk for having penile lesions [20]. The incidence of HPV DNA in men is lower than in women, so questions rose about the possible modes of sexual transmission of HPV.…”

Section: Interaction Of Semen and Hpvmentioning

confidence: 99%

“…5). Sucrose sedimentation analysis also showed that there is a large amount of not, or only partially assembled molecules, presumably capsomeres (fractions [18][19][20][21][22][23][24], as well as other larger aggregates (fractions 1-8) when compared to the insect cell-produced protein (Maclean et al, 2007). L1VLPs can be produced either in transgenic plants stably transformed with an expression cassette or transiently using one of several available plant-virus derived expression systems.…”

Section: L1 Based Prophylactic Vaccines and The Yields Of L1 Producedmentioning

confidence: 99%

“…Loops between strands are labeled B-C, C-D, etc. The first and the last residues are marked N (20) and C (474), respectively. The two cysteines that participate in the interpentamer disulphide bonding within the virion or in the virion-sized particles are shown in yellow, together with their residue numbers, 175 and 428.…”

Section: Structure Of Hpv Capsid and Neutralizing Epitopes On Its Surmentioning

confidence: 99%

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Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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Section: Interaction Of Semen and Hpvmentioning

confidence: 99%

Section: L1 Based Prophylactic Vaccines and The Yields Of L1 Producedmentioning

confidence: 99%

Section: Structure Of Hpv Capsid and Neutralizing Epitopes On Its Surmentioning

confidence: 99%

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Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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“…Although many penile lesions aresubclinical anddifficult todetect without acetic acidand colpos copy,when a careful examination isper formed, in60 to80 percent of cases the current malepartner ofwomen withabnor mal smears will have a genital tract le sion. 25 The basic principle in the treatment evalu ation of any cancer can be stated simply:…”

Section: Colposcopy and Biopsy Techniquesmentioning

confidence: 99%

Cervical Intraepithelial Neoplasia (Dysplasia and Carcinoma in Situ) And Early Invasive Cervical Carcinoma

Nelson

Averette

Richart

1989

CA: A Cancer Journal for Clinicians

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IntroductionCervical intraepithelial neoplasia (dyspla sia and carcinoma in situ) and early inva sive carcinoma of the cervix are increas ingly important aspects of the cervical cancer problem. The mounting frequency with which these diagnoses are made is directly related to the increased use of the severe dysplasia/carcinoma in situ). These lesions arise at the squamocol umnar junction in the transformation zone, usually as unifocal lesions, and are con fined to the transformation zone or endo cervical canal during the intraepithelial stage. Although invasion may occur at any phase of CIN, it is much more likely to occur in CIN 3. These higher grade lesions are regarded as more ominous than the lower grade precursors; the immediate risk of invasion in the individual patient, how ever, cannot be predicted.3 Screening techniques should be de signed to detect early lesions and those with a low turnover time that exfoliate only a

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“…By various DNA filter hybridization techniques, surveys of clinically normal women estimate that 5-50% can be found to harbor papillomaviruses in their genital tracts (13)(14)(15)(16)(17). The sexually transmitted nature of this clinically significant HPVassociated disease is apparent from the fact that up to 65% of male consorts of women with genital warts or neoplasia also have warty or neoplastic lesions (18,19).…”

mentioning

confidence: 99%

A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma.

Ostrow

McGlennen

Shaver

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

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Recently we molecularly cloned and characterized a papillomavirus from a lymph node metastasis of a primary penile carcinoma found in a rhesus monkey; this virus species, rhesus papillomavirus type 1 (RhPV-1), is similar to oncogenic human papillomaviruses (HPVs), such as HPV-16 or HPV-18, in that the RhPV-1 DNA was found to be integrated in the tumor cell DNA. To compare the sexual transmission and oncogenic nature ofRhPV-1 with these HPVs, we undertook an extensive retrospective study of a group of rhesus monkeys whose sexual mating and offspring histories were known. These animals had mated directly with the index male mentioned above or were secondarily exposed to this virus through intermediate sexual partners. This study combines cytological, histopathological, and several complementary hybridization and DNA amplification techniques on multiple tissue samples to demonstrate the sexually transmitted nature of RhPV-1. The oncogenic potential of RhPV-1 is suggested in several of the infected animals by the presence of various degrees of neoplasia including squamous cell cancer of the cervix.The compelling evidence that certain types of human papillomavirus (HPV) are associated with malignancies of the anogenital tract has been based largely upon the detection of HPV DNA in various tissues (for review, see ref.

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Papillomavirus infection and cervical intraepithelial neoplasia: A study of male sexual partners

Cited by 35 publications

References 0 publications

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Cervical Intraepithelial Neoplasia (Dysplasia and Carcinoma in Situ) And Early Invasive Cervical Carcinoma

A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma.

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