A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma.

Ostrow, Ronald S.; McGlennen, Ronald C.; Shaver, Mohammad; Kloster, B E; Houser, D; Faras, Anthony J.

doi:10.1073/pnas.87.20.8170

Cited by 49 publications

(55 citation statements)

References 19 publications

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“…The animals at TRPRC have also lived in social groups permitting sexual interactions. We have included serum samples from animals previously tested for RhPV-I DNA (Ostrow et al, 1990). This included serum from the index male from which RhPV-1 was first isolated (Kloster et al, 1988).…”

Section: Methodsmentioning

confidence: 99%

“…Freshly frozen cervical smears were obtained from the Tulane Regional Primate Research Center (TRPRC). Serological specimens were obtained from each of these two institutions as well as the Wisconsin Regional Primate Research Center (WRPRC), and from the Harlow Primate Laboratory (HPL), where we had previously demonstrated RhPV-1 infections using molecular and pathological evidence (Ostrow et al, 1990). Animals from RWJPRI were caught in the wild in approximately 1975 and individually housed.…”

Section: Methodsmentioning

confidence: 99%

“…Subsequently other animals at the same facility were tested for the presence of the virus by molecular and pathological techniques (Ostrow et al, 1990). About 40% of the tested animals which were within the same mating cohort as the male rhesus monkey were found to have RhPV-1 DNA and/or evidence of genital neoplasia consistent with papillomavirus infection.…”

Section: Introductionmentioning

confidence: 99%

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Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Ostrow¹,

Coughlin²,

McGlennen

et al. 1995

Journal of General Virology

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We have previously demonstrated the presence of rhesus monkey papillomavirus type 1 (RhPV-1), from molecular and pathological evidence, in a mating group within a single institution. We have now also obtained a number of fresh or archival tissues of rhesus monkeys from other geographically distinct institutions. Using PCR amplification, we observed two animals from one of these institutions and five animals from another which demonstrated RhPV-1 DNA sequences. In addition we molecularly cloned the E7, E2, E4, L2 and L1 genes of RhPV-1 into bacterial expression vectors. The fusion gene products were used to test for serological response to RhPV-1 antigens by Western blot analysis. Responses were observed in up to 52 % of the animals tested. While some serologically positive animals were also RhPV-1 DNA-positive, most were not.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Ostrow¹,

Coughlin²,

McGlennen

et al. 1995

Journal of General Virology

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“…Genital papillomas have been well documented in colobus monkey Colobus guereza and rhesus monkey Maccaca mulatta and are venereally transmitted in the latter species (O'Bannion et al 1987, Ostrow et al 1990, Reszka et al 1991.…”

Section: Introductionmentioning

confidence: 99%

Genital and lingual warts in small cetaceans from coastal Peru

Bressem¹,

Waerebeek²,

Piérard³

et al. 1996

Dis. Aquat. Org.

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ABSTRACT-We report on genital warts in dusky dolphins Lagenorhynchus obscurus, long-snouted common dolphins Delphinus capensis, bottlenose dolphins Tursiops truncatus and Burmeister's porpoises Phocoena spinipinnis caught in fisheries off central Peru. Lesions were observed inside the genital slit, on the skin adjacent to it, on the penis and on the vagina. Macro-and microscopical features of the lesions resemble those of benign genital warts associated with papillomavirus infection in humans Genital warts from L, obscurus and P spinipinnis contained nuclei which stained positive for genus-specific papillomavirus structural antigens, though weakly in the latter species. These data suggest that papillomavirus(es) may be the etiological agent(s) of the disease. The prevalence of the lesions in 130 small cetaceans was high: 66.7% (confidence interval, CI, 57.0 to 74.0%) in L. obscurus (n = 78). 50% in D. capensis (n = 10), 33% in T truncatus (n = 9) and 48.5% (C1 33.0 to 64.0%) In P. spinipinnis (n = 33). This suggests a venereal transmission of the disease, as in humans. Sexual variation in wart prevalence was found in L. obscurus and P spinipinnis with males being 2 and 3 times more infected than females, respectively. No correlation was observed between body length (as a measure of age) and wart prevalence, suggesting that no strong and long-lasting immunity was induced in affected animals or that they may have been infected by different types of papillomaviruses. Lingual tumours were seen in 1 D. capensis.

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“…We find viruses similar to HPv in primates, which would suggest its existence in man and the chimp's common ancestor (ostrow et al, 1990;Reszka et al, 1991;Chan et al, 1997).…”

mentioning

confidence: 93%

A história da disseminação dos microrganismos

Ujvari

2008

Estud. av.

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O Homo sapiens nasceu portando agentes infecciosos que circulavam no animal ancestral comum ao homem e chimpanzé. Adquirimos outros microrganismos ainda no solo africano, época dos caçadores e coletores. Partimos da África, conquistamos o planeta e nos tornamos sedentários. Descobrimos a agricultura e a domesticação dos animais e, com isso, fomos invadidos por novos agentes infecciosos. Os microrganismos apanharam carona nas locomoções humanas. Estavam presentes nas migrações humanas originadas da África, nas campanhas militares da Antigüidade, nas viagens marítimas de descobrimentos, nas colonizações, no tráfico de escravos e outros. O avanço no estudo do DNA e RNA de microrganismos nos esclarece a origem e o dispersar de várias doenças infecciosas. Descobrimos, então, como estamos globalizando vírus, bactérias e parasitos desde nossa saída da África até os dias atuais.

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A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma.

Cited by 49 publications

References 19 publications

Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Genital and lingual warts in small cetaceans from coastal Peru

A história da disseminação dos microrganismos

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