Papillary Tumor of the Pineal Region

Vandergriff, Clayton; Opatowsky, Michael J.; O’Rourke, Brian; Layton, Kennith F.

doi:10.1080/08998280.2012.11928791

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…Tumors at the time of diagnosis are quite big, being 5-50 mm in diameter (average 29 mm) and nearly in half of the patients they cause hydrocephalus [14]. In the majority of MR imaging reports of PTPR, the tumor looks like a heterogeneously enhanced pineal region mildly lobulated mass with cystic compartments [3,[15][16][17]. The intrinsic hyperintensity on non-contrast T1-weighed sequences in the absence of fat, hemorrhage, melanin or calcifications is considered to be a characteristic MRI appearance of this tumor [15].…”

Section: Discussionmentioning

confidence: 99%

Papillary tumor of the pineal region. Report of two cases and literature review

Koziarski

Grala

Skrobowska

2014

Neurologia i Neurochirurgia Polska

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Papillary tumor of the pineal region (PTPR) was introduced to the WHO classification in 2007. This rare tumor of little known natural history and unpredictable behavior was described in fewer than 100 cases. Its optimal treatment is not established yet. We report another two cases of PTPR in whom tumors were totally removed via supracerebellar infratentorial approach and both were treated with radiotherapy. In a 37-year-old man the operation was delayed 6 years after the first tumor diagnosis and subsequent shunt placement. He has no complaints 10 years after the onset of the disease. A 45-year-old woman has no complaints 24 months after surgery. Our experience and the data from literature indicate that a total tumor removal is the major prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Papillary tumor of the pineal region. Report of two cases and literature review

Koziarski

Grala

Skrobowska

2014

Neurologia i Neurochirurgia Polska

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“…It is important to underline that pineal papillary tumors present wide morphological variability [ 82 , 92 , 93 , 94 , 95 ]. Apart from the characteristic papillary structures, papillary tumors have morphological features in common with other papillary-like tumors that occur in the pineal region, including pineal parenchymal neoplasms, choroid plexus papillomas, papillary ependymomas, metastatic papillary carcinomas, papillary meningiomas, and germ cell tumors, which complicates the clinical diagnosis [ 60 , 83 , 87 , 92 , 96 , 97 ]. These pineal tumors often present increased proliferative activity (Ki67/MIB1 proliferation index) [ 90 ], which is correlated with worse prognosis.…”

Section: Pineal Gland Tumorsmentioning

confidence: 99%

Pineal Gland Tumors: A Review

Favero

Bonomini

Rezzani

2021

Cancers

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The pineal gland is a small, pinecone-shaped endocrine gland that participates in the biological rhythm regulation of vertebrates. The recognized major product of the pineal gland is melatonin—a multifunctional endogenous indoleamine. Accumulating evidence suggests that the pineal gland is important for preserving ideal health conditions in vertebrate. Tumors of the pineal region account for approximately 3–11% of pediatric brain neoplasms but fewer than 1% of brain neoplasms in adults. It is fundamental to expand advanced imaging techniques together with both clinical and laboratory knowledge, to help to differentiate among pineal neoplasms and thus facilitate accurate primary diagnoses and proper therapeutic interventions. In this review, we report the gross anatomy of the pineal gland and its functional significance and discuss the clinical relevance of pineal gland tumors, underlining the importance of identifying the leading causes of pineal region masses.

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“…In 2007, PTPR was included in the World Health Organization classification of central nervous system tumors ( 2 ). PTPR does not arise from the pineal gland itself, but originates from specialized cytokeratin-positive and nestin-positive ependymal cells that are derived from the subcommissural organ ( 3 – 5 ). Tumors of the pineal region are rare lesions, accounting for only 1% of all intracranial tumors ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…Tumors of the pineal region are rare lesions, accounting for only 1% of all intracranial tumors ( 6 ). PTPR have morphological features in common with a number of other papillary-like tumors that occur in the pineal region, including pineal parenchymal neoplasms, choroid plexus papilloma, papillary ependymoma, metastatic papillary carcinomas, papillary meningioma and germ cell tumors ( 5 , 7 ), which complicates the clinical diagnosis of PTPR. Clinical presentation most often includes headache and obstructive hydrocephalus.…”

Section: Introductionmentioning

confidence: 99%

Papillary tumor of the pineal region: A case report and review of the literature

Hua

Yang

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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Papillary tumor of the pineal region (PTPR) was first described as a distinct tumor entity in 2003 and was introduced into the World Health Organization classification of central nervous system tumors in 2007. This tumor is rare and, to the best of our knowledge, only 7 cases have been reported in children <16 years of age, while the youngest documented patient was a 15-month-old boy. The present study reported a case of PTPR in a 10-year-old girl who underwent magnetic resonance imaging and surgical resection of tumors. Histological and immunohistochemical staining results were presented. Patients with PTPR require long-term follow-up, and the patient of the present study has continued to do well, with no recurrence of the tumor at the 15-month follow-up examination. In addition, a review of the literature on this unusual neoplasm was performed, along with discussion of their differential diagnosis.

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Papillary Tumor of the Pineal Region

Cited by 11 publications

References 4 publications

Papillary tumor of the pineal region. Report of two cases and literature review

Papillary tumor of the pineal region. Report of two cases and literature review

Pineal Gland Tumors: A Review

Papillary tumor of the pineal region: A case report and review of the literature

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