Papillary thyroid carcinoma: prognostic factors and the role of radioiodine and external radiotherapy

Chow, Sin Ming; Law, Stephen C.K.; Mendenhall, William M.; Au, Siu Kie; Chan, Pak Tat; Leung, TW; Tong, Chi-Chung; Wong, I.S.M.; Lau, W.S.

doi:10.1016/s0360-3016(01)02686-4

Cited by 120 publications

(80 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…25 In general, we prefer bilateral thyroidectomy for patients with PTC, because total or near-total thyroidectomy results in fewer recurrences compared with unilateral surgical procedures. For incidental finding of PTC, we would discuss with patients the options of completion thyroidectomy and RAI ablation.…”

Section: Management Strategymentioning

confidence: 99%

“…Despite the documented effectiveness of RAI for the treatment of patients with differentiated thyroid carcinoma, such as reductions in recurrence rates, 25,32,[35][36][37][38] the regression of DM, 40 -43 and improvements in survival, 25,32,35,36,44 a recently published study of 2444 patients from a single institute refuted these findings. 45 The possible reasons for this disagreement may be related to the bulk or volume of tumor left after surgery.…”

Section: Treatment Of Patients With Pmcmentioning

confidence: 99%

See 1 more Smart Citation

Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality

Chow

Law

Chan

et al. 2003

Cancer

Self Cite

669

479

View full text Add to dashboard Cite

Portable electronic devices operate at varying power demand levels. This variability of power demand must be considered explicitly in the design of man‐portable power generation systems for acceptable performance and portability. In this regard, a mathematical programming based design method is proposed. The method transcribes optimal operation of the system at a given power demand into a mathematical program. The power demand specific programs are incorporated into another upper level mathematical program encoding design requirements to form a final two‐stage formulation. The design and operational parameters of the power generation system comprise a solution of the formulation. Unlike designs, based on a nominal power demand, the design guarantees that each power demand and all operational requirements can be satisfied. A detailed study of a microfabricated fuel‐cell based system is performed. The proposed method produces smaller designs with significantly better performances than nominal power demand based approaches. © 2008 American Institute of Chemical Engineers AIChE J, 2008

show abstract

Section: Management Strategymentioning

confidence: 99%

Section: Treatment Of Patients With Pmcmentioning

confidence: 99%

Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality

Chow

Law

Chan

et al. 2003

Cancer

Self Cite

669

479

View full text Add to dashboard Cite

show abstract

“…Conservative surgical treatment as a subtotal thyroidectomy for follicular thyroid carcinomas of less than 3 cm resulted in 9.5% of distant metastases [51]. Aggressive total thyroidectomy with a negative resection margin regardless of tumor size had freedom from distant metastases of 90.6% [52]. Otherwise, definite diagnoses of adenoma or carcinoma are sometimes difficult to arrive at during surgery.…”

Section: Treatmentmentioning

confidence: 99%

Follicular Thyroid Carcinoma: From Diagnosis to Treatment

Lin

Chao

2006

Endocr J

View full text Add to dashboard Cite

Abstract. Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the preoperative or intra-operative stage of treatment. Fine needle aspiration cytology has been shown to be an ineffective method for diagnosing vascular or capsule invasion of follicular thyroid cancer. Multiple frozen sections, usually 5 to 12 depending on the size of the tumor, can achieve a diagnostic accuracy of 98%. Clinical application of various gene expressions in thyroid follicular tumors by needle aspiration using in situ hybridization requires further investigation. Although radioactive iodide ( 131 I) has been used as the standard treatment for follicular thyroid carcinoma with distant metastases, the effectiveness of 131 I treatment for follicular thyroid carcinoma depends on the differentiation of cancer cells. The possibility of 131 I for thyroid remnant ablation replacing a secondary operation for follicular thyroid carcinoma has been debated. Recent studies applied more expressions of sodium iodide symporters to attain the effect of 131 I treatment and slow the proliferation of thyroid cancer cell which, in turn, slows the progression of follicular carcinoma. Consensus for the surgical procedures for the specific prognostic risks for follicular thyroid carcinoma is needed. Dedifferentiated, anti-angiogenic, or gene therapies for follicular thyroid cancer with distant metastases or anaplastic transformation comprise the principal directions in future research for this cancer.

show abstract

“…This could be a result of fewer patients in most studies, which means that small variations in the variables analyzed can lead to a prognostic factor being significant or not. As a general rule, the following prognostic factors have been reported for this type of carcinoma: age, tumor differentiation, vascular invasion, distant metastasis, nodular affectation, capsular invasion, and tumor extension (13,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37), although, as we have already mentioned, there is a great amount of variability between studies.…”

Section: Discussionmentioning

confidence: 83%

Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?

Rı́os¹,

Rodrı́guez²,

Ferri

et al. 2013

European Journal of Endocrinology

View full text Add to dashboard Cite

Purpose: Most prognostic systems for differentiated carcinoma have been designed for papillary carcinoma. Objective: To analyze the value of the existing prognostic systems for evaluating follicular carcinoma and to determine whether any of them have a better predictive effect. Methods: A total of 66 follicular carcinomas were analyzed. The following prognostic systems were studied: EORTC, AGES, AMES, MACIS, TNM, and NTCTCS. Results: The AGES and AMES systems did not demonstrate a good prognostic correlation. In the EORTC system, the rate of disease-free patients was 89% in group 1, 75% in group 2, 69% in group 3, and 0% in group 4. The MACIS system showed 83, 60, 67, and 0% of disease-free patients respectively. The TNM system showed 81, 71, 50, and 0% of disease-free patients respectively. Finally, the NTCTCS system demonstrated 100, 84, 53, and 0% of disease-free patients respectively. Cox's regression analysis was used to calculate the proportion of variation in survival time explained (PVE). The prognostic classification system with the greatest survival prediction was EORTC at 67.64% of PVE, followed by TNM at 62.5% of PVE, and MACIS at 57.82% of PVE. Conclusions: MACIS and TNM are good prognostic systems for evaluating follicular thyroid carcinoma, although the one with the most prognostic value was the EORTC system.

show abstract

Papillary thyroid carcinoma: prognostic factors and the role of radioiodine and external radiotherapy

Cited by 120 publications

References 38 publications

Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality

Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality

Follicular Thyroid Carcinoma: From Diagnosis to Treatment

Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?

Contact Info

Product

Resources

About