Portable electronic devices operate at varying power demand levels. This variability of power demand must be considered explicitly in the design of man‐portable power generation systems for acceptable performance and portability. In this regard, a mathematical programming based design method is proposed. The method transcribes optimal operation of the system at a given power demand into a mathematical program. The power demand specific programs are incorporated into another upper level mathematical program encoding design requirements to form a final two‐stage formulation. The design and operational parameters of the power generation system comprise a solution of the formulation. Unlike designs, based on a nominal power demand, the design guarantees that each power demand and all operational requirements can be satisfied. A detailed study of a microfabricated fuel‐cell based system is performed. The proposed method produces smaller designs with significantly better performances than nominal power demand based approaches. © 2008 American Institute of Chemical Engineers AIChE J, 2008

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Preliminary results confirmed that CRT could significantly improve tumor control, particularly at locoregional sites. However, there was significant increase in the risk of toxicities and no early gain in overall survival. Longer follow-up is needed to confirm the ultimate therapeutic ratio.