Papillary Thyroid Carcinoma

Halenka, Milan; Fryšák, Zdeněk

doi:10.1007/978-3-319-53759-7_15

Cited by 3 publications

(2 citation statements)

References 65 publications

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“…Based on the predominantly follicular growth pattern, papillary thyroid carcinomas (PTCs) include several subtypes. The present treatments of PTC encompass surgery, hormone therapy over the past decades and the prevalence of different genetically profiles have altered over time [ 1 ]. Except medullary thyroid carcinoma, all thyroid malignancies are derived from thyroid follicular cells [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative and apoptotic effects of hull-less pumpkin extract on human papillary thyroid carcinoma cell line

et al. 2021

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Papillary thyroid carcinoma (PTC) is one of the most common cancers of the endocrine system. Previous studies have shown that the extract of hull-less pumpkin seed (HLPS) has a significant anti-cancer effect. The aim of this study was to evaluate the effect of this plant extract on the proliferation of PTC cells. In this study, an extract of this plant was prepared by soxhlet extraction method and analyzed by Gas Chromatography-Mass Spectrometry. The cytotoxicity of PTX and plant extract was investigated using the methylthiazol tetrazolium (MTT) method. For careful investigation of morphological alteration, we used hematoxylin and eosin and Giemsa stinging. Based on MTT assay test, the IC 50 value of paclitaxel (PTX) was significantly less than the hydro-alcoholic extract of HLPS at all of the incubation time. Our results of histological staining showed that HLPS and PTX induced significant morphological alteration in the PTC cultured cell that consistent with cell death. Comparing the groups treated by PTX or HLPS with control group showed significant differences. It seems that HLPS extract has an apparent effect on treatment of PTC, at least in laboratory condition, albeit for realistic decision about the effect of HLPS on PTC, more molecular investigations are necessary.

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Section: Introductionmentioning

confidence: 99%

Anti-proliferative and apoptotic effects of hull-less pumpkin extract on human papillary thyroid carcinoma cell line

et al. 2021

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“…Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma which accounts for approximate 85%~70% cases of thyroid carcinoma (PTC). 1,2 As a kind of differentiated thyroid carcinoma (DTC), PTC patients always have better prognosis with slighter malignance. 3,4 However, prognosis for patients with recurrence and metastasis is still poor, with a 5-year survival rate only about 50%.…”

Section: Introductionmentioning

confidence: 99%

CKS1B promotes cell proliferation and invasion by activating STAT3/PD‐L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma

Wang

Zhang

Yan

et al. 2020

Clinical Laboratory Analysis

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Objective To investigate role of GKS1B and its relationship between STAT3/PD‐L1 and p‐Akt in papillary thyroid carcinoma (PTC). Methods Expression of GKS1B and PD‐L1 was determined in PTC cell lines. GKS1B was overexpressed or knocked down by transfection with overexpression plasmids or si‐CKS1B. STAT3 inhibitor WP1066 was used to suppress STAT3, and PD‐L1 inhibitor Pembrolizumab was used to block PD‐L1. Cell viability and invasion were evaluated by MTT and transwell assay, respectively. The expression of STAT3, p‐STAT3, Akt, and p‐Akt was measured using Western blotting. Results Both protein levels and mRNA levels of CKS1B and PD‐L1 were remarkably up‐regulated in PTC cell lines. Knockdown of CKS1B significantly inhibited cell viability and invasion of PTC cells and suppressed STAT3/PD‐L1 signaling and Akt phosphorylation, while overexpression of CKS1B led to opposite results. Inhibition of STAT3 or PD‐L1 reversed the effects of overexpressed CKS1B on PTC cells. Conclusion The overexpression of CSK1B could promote cell viability and invasion of PTC cells through activation of STAT3/PD‐L1 signaling and Akt phosphorylation.

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