Association Between Papillary Thyroid Cancer and Allergy: A Case-Control Study

Shirkhoda, Mohammad; Nejad, Vahab Malekshahi; Eslami, Bita; Zebardast, Jayran; Jalaeefar, Amirmohsen

doi:10.5812/ijcm.69512

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Shirkhoda et al reported that allergic rhinitis patients had a reduced risk of papillary thyroid cancer (adjusted odds ratio, 0.07) in a case–control study 35 . In other population‐based epidemiologic studies, Hwang et al and Meinhold et al showed a positive association between thyroid cancer and asthma (adjusted HR, 1.23 and 1.49, respectively) 36,37 .…”

Section: Discussionmentioning

confidence: 98%

Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population‐Based Cohort Study

et al. 2022

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Objective: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases. The effect of chronic inflammation caused by CRS on the occurrence of various cancers has not been thoroughly evaluated. This study aimed to investigate the increased incidences of 10 types of cancers among CRS patients with/without nasal polyps (NP) using a national population-based database from the Korean Health Insurance Review and Assessment Service.Study Design: A case-control cohort study. Methods: We compared the prevalence of various comorbidities between CRS and control participants from a national cohort dataset of the Korean Health Insurance Review and Assessment Service.Methods: CRS participants (n = 6,919) and non-CRS (n = 27,676) participants were selected from among the 514,866 participants from 2002 to 2015. A stratified Cox proportional hazards model was utilized to assess the hazard ratio (HR) of CRS for 10 types of cancers.Results: A stratified Cox proportional hazard model demonstrated that the adjusted HR for hematologic malignancy was significantly higher in the CRS patients than in the controls regardless of the presence of NP (2.90 for total CRS; 2.15 for CRS with NP; 4.48 for CRS without NP). The HR for thyroid cancer was significantly higher in the CRS patients without NP but not in those with NP (1.50 for total CRS; 1.78 for CRS without NP).Conclusion: This study showed that CRS participants had a significantly higher prevalence of hematologic malignancy and thyroid cancer.

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Section: Discussionmentioning

confidence: 98%

Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population‐Based Cohort Study

et al. 2022

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The Multiomics Analyses of Gut Microbiota, Urine Metabolome and Plasma Proteome Revealed Significant Changes in Allergy Featured with Indole Derivatives of Tryptophan

Zhen

Zhao

et al. 2022

JAA

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Objective To explore changes in the gut microbiota (GM), urine metabolome and plasma proteome in individuals with allergies using multiomics analyses, and identify the key components and mechanism. Methods This was a cross-sectional study. All subjects were recruited to collect fecal, urine and blood samples. 16S rDNA sequencing was used to analyze the structure and function of the GM, liquid chromatography mass spectrometry was used to quantify metabolites in the urine, and data-independent acquisition quantitative proteome analysis was used to detect proteins in the plasma. Differences in GM, urine metabolites and plasma proteins between allergic and healthy individuals were displayed using principal component analysis (PCoA) and heatmap, and the co-occurrence network was visualized in Cytoscape using Spearman correlation among differential predominant genera, metabolites and proteins. The functional analysis was performed according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) dataset. The allergy-related cytokines, IL-4, IL-6 and IL-13, were measured to evaluate the effect of indole derivatives on LPS-induced macrophage activation. Results GM α indexes, β distances and the relative abundance of the core differential genera in the allergic group were different from those of healthy individuals, which resulted in a separate distribution in the PCoA and enterotypes. Similarly, the concentrations of 393 metabolites and 144 proteins were different between allergic and healthy individuals. Then, 634 significant correlations were identified among 6 predominant differential genera, 24 differential metabolites and 104 differential proteins, 301 of which were negative and 333 of which were positive. Notably, a core network centered on tryptophan metabolites, indole-3-butyric acid (IBA) and indole-3-lactic acid (ILA), displayed high consistency with the results of KEGG pathway analysis. In the LPS-stimulated macrophages, IBA reduced the expression of IL-4 and IL-6, and ILA inhibited the upregulation of IL-6. Conclusion The GM, urine metabolome and plasma proteome underwent systematic change in allergic individuals compared to healthy individuals, among which indole derivatives from tryptophan metabolism might play key roles in the progression of allergies and could serve as therapeutic targets of allergy.

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Association Between Papillary Thyroid Cancer and Allergy: A Case-Control Study

Cited by 2 publications

References 37 publications

Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population‐Based Cohort Study

Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population‐Based Cohort Study

The Multiomics Analyses of Gut Microbiota, Urine Metabolome and Plasma Proteome Revealed Significant Changes in Allergy Featured with Indole Derivatives of Tryptophan

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