Papillary ovarian tumors

Malloy, John J.; Dockerty, Malcolm B.; Welch, John S.; Hunt, Arthur B.

doi:10.1016/0002-9378(65)90087-6

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…Such a finding has been reported before (e.g. Malloy et al, 1965;Munnell et al, 1957), but remains surprising, in view of the additional risk of dissemination of malignant cells. This is the pattern of distribution found in most series (Saxen and Hakama, 1964), and may be taken as representative.…”

Section: Methodssupporting

confidence: 57%

“…Among the serous tumours have been included " mesonephromas " of the adult type and endometrioid tumours. The criteria for the diagnosis of endometrioid carcinomas have been laid down by Long and Taylor (1964), but the reported incidence of these tumours in various series ranging from from 4-8 per cent (Malloy, Dockerty, Welch and Hunt, 1965) through 11 per cent (Schueller andKirol, 1966), 16-7 per cent (Long andTaylor, 1964) to 24 per cent (Santesson, quoted by Long and Taylor, 1964): confirms our experience that it is impossible to discriminate between the poorly differentiated serous and endometrioid carcinomas. The well differentiated endometrioid carcinomas, especially when they show squamous metaplasia, are readily identifiable (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…2). Following the lead of others who have discussed the presence of squamous metaplasia as an indication of high grade malignancy (Pemberton, 1940;Malloy et al, 1965), solid masses of squamous epithelium were initially regarded in this survey as a sign of a high level of malignancy, but it became clear that this was erroneous, and that the malignant potential-as in the uterine adenoacanthoma (Novak and Nally, 1957) lies in the glandular epithelium.…”

Section: Methodsmentioning

confidence: 99%

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Factors Influencing Survival in Carcinoma of the Ovary

Dyson¹,

Beilby²,

Steele³

1971

Br J Cancer

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SUMMARY.-Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic activity, which proved a significant feature per se in assessing prognosis in ovarian cancer.A SURVEY has been carred out on 319 patients with primary adenocarcinoma of the ovary to evaluate some of the factors which influence survival in this disease. It became apparent during the investigation that the mitotic count was of considerable prognostic significance. Other factors considered were the histological type of the tumour, the stage to which it had spread at the time of operation and its histological grade. Ford (1928) was the first person to evaluate the prognosis according to the stage of spread at the time of operation, and the first large series was published in 1932 (Heyman, 1932). The first paper on grading appeqred at much the same time (Taylor, 1929), and most series since that of Pemberton (1940) have treated it as an important prognostic factor.Although cellular atypicality, as a feature of malignancy, has been discussed frequently in relation to grading, mitotic activity has received much less attention. Barzilai (1943) reported that mitoses were "frequently seen " in the group of tumours which she called " sero-anaplastic", and Allan and Hertig (1949) used profusion of mitoses as one of the indicators of the most malignant neoplasms. But at the time when this study was undertaken, no publication had been found in which mitoses were considered as a separate feature. The only published work specifically devoted to this point was by Novak and Woodruff (1967) after the present investigation had been largely completed. It confirms that the count of mitoses per high power field is of prognostic significance in carcinoma of the ovary.

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Section: Methodssupporting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Factors Influencing Survival in Carcinoma of the Ovary

Dyson¹,

Beilby²,

Steele³

1971

Br J Cancer

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Ovarian adenocarcinoma of mesonephric type

Norris

Robinowitz

1971

Cancer

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Endometrioid and clear cell carcinoma of the ovary

Kurman

Craig

1972

Cancer

103

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Two hundred and thirty cases of primary ovarian carcinoma derived from the surface epithelium of the ovary were reviewed over a 30‐year period ending in 1960. Of these, 37 (16%) were classified as endometrioid and 12 (5%) as clear cell carcinomas. The 5‐ and 10‐year survival for patients with endometrioid carcinoma was 46% and 37%, respectively, and for those with clear cell carcinoma, 27% and 18%, respectively. Factors which proved to be quite useful in predicting the behavior of endometrioid carcinoma were the stage and grade of the tumor; the “purity” was of limited value. Stage I patients had a 69% and 63%, 5‐ and 10‐year survival; there were no Stage III and IV survivors. Patients with low‐grade tumors had a better prognosis than those with high‐grade tumors and those with “pure” tumors had a more favorable prognosis than those with “mixed” tumors. In analyzing clear cell carcinoma, it was noted that the stage was crucial since in those patients with tumor confined to the ovary the 5‐ and 10‐year survival was 50% compared to the overall survival of 27% and 18%. Our group of patients with endometrioid carcinoma was then combined with other series of endometrioid carcinoma reported in the literature over the past 10 years in order to put the statistics into clearer perspective. The mean incidence thus obtained was 18% and the mean 5‐year survival, 47%. Lastly, the histogenesis of clear cell carcinoma was studied in relation to endometriosis and endometrioid carcinoma. Four cases (11%) of endometrioid carcinoma were closely associated with and one case (8%) of clear cell carcinoma developed from endometriosis. The finding of clear cells mixed with all types of primary carcinoma of the ovary derived from the surface epithelium makes it appear that clear cell carcinoma, like endometrioid carcinoma, may on occasion develop from endometriosis but that more often it arises de novo from the surface epithelium of the ovary. Therefore, despite its relatively high association with endometriosis, the frequent combination of clear cell elements mixed with other primary ovarian carcinoma and its somewhat different prognosis lead us to conclude that clear cell and endometrioid carcinomas are related but distinct entities.

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Papillary ovarian tumors

Cited by 14 publications

References 7 publications

Factors Influencing Survival in Carcinoma of the Ovary

Factors Influencing Survival in Carcinoma of the Ovary

Ovarian adenocarcinoma of mesonephric type

Endometrioid and clear cell carcinoma of the ovary

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