Papillary muscle traction in mitral valve prolapse: Quantitation by two-dimensional echocardiography

Sanfilippo, Anthony J.; Harrigan, Pamela; Popović, Aleksandar D.; Weyman, Arthur E.; Levine, Robert A.

doi:10.1016/s0735-1097(10)80274-8

Cited by 91 publications

(56 citation statements)

References 29 publications

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“…Papillary muscle traction may result in left ventricular contraction and relaxation abnormalities and activation of stretch receptors. Stretch receptor activation may result in membrane depolarization and cardiac arrhythmias [77,78,79]. …”

Section: Classificationmentioning

confidence: 99%

Floppy Mitral Valve (FMV)/Mitral Valve Prolapse (MVP) and the FMV/MVP Syndrome: Pathophysiologic Mechanisms and Pathogenesis of Symptoms

Boudoulas¹,

Boudoulas

2013

Cardiology

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Mitral valve prolapse (MVP) results from the systolic movement of a portion or segments of the mitral valve leaflets into the left atrium during left ventricular systole. It is well appreciated today that floppy mitral valve (FMV) is the central issue in the MVP and mitral valve regurgitation (MVR) story. The term FMV refers to the expansion of the area of the mitral valve leaflets with elongated chordae tendineae, chordae rupture and mitral annular dilation. FMV/MVP occurs in a heterogeneous group of patients with a wide spectrum of mitral valve involvement from mild to severe. Two types of symptoms can be defined in FMV/MVP patients. In one group of patients, symptoms are directly related to progressive MVR. In the other group, symptoms cannot be explained by the degree of MVR alone; activation of the autonomic nervous system has been implicated for the explanation of symptoms in this group of patients which is referred to as the FMV/MVP syndrome. In this brief review, the natural history, pathophysiologic mechanisms and management of patients with FMV/MVP/MVR and FMV/MVP syndrome are discussed.

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Section: Classificationmentioning

confidence: 99%

Floppy Mitral Valve (FMV)/Mitral Valve Prolapse (MVP) and the FMV/MVP Syndrome: Pathophysiologic Mechanisms and Pathogenesis of Symptoms

Boudoulas¹,

Boudoulas

2013

Cardiology

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“…In many cases these symptoms precede significant mitral valve regurgitation and are more common in women than in men. These symptoms seem related to neuroendocrine or autonomic nervous system functional abnormalities and to anatomic and functional mitral valve alterations [15][16][17].…”

Section: Floppy Mitral Valve Syndromementioning

confidence: 99%

Floppy Mitral Valve Syndrome

Minardi¹,

Pulignano²,

Denitza³

et al. 2017

J Cardiovasc Dis Diagn

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“…Mitral regurgitation is due to a combination of leaflet and chordal extensibility and elongation probably together with superior papillary muscle displacement or traction (6,7). The billowing leaflets may appear diffusely thickened ("Barlow's syndrome") or thin except in flail portions ("Fibroelastic deficiency").…”

Section: Mitral Valve Pathology Mitral Valve Prolapsementioning

confidence: 99%

Mitral Valve Pathology: Challenges and Solutions – A Short Overview

Marx¹,

Zimpfer²

2017

International Symposium MITRAL VALVE DISEASES IN CHILDREN AND ADULTS

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Mitral valve prolapse (MVP) is the most common valve disease (prevalence of 2 to 3%). Although MVP is generally regarded as a benign condition, complications such as mitral regurgitation, atrial fibrillation, congestive heart failure, endocarditis and stroke are well known. MVP is a significant cause of SCD where CE-CMR (contrast-enhanced MRI) might allow the identification of this arrhythmic substrate. Transcatheter mitral valve interventions are progressively being introduced into clinical practice targeting a population of patients with mitral regurgitation (MR). Beyond percutaneous edge to edge repair (MitraClip®), a percutaneous surgical-like direct annuloplasty device but also transcatheter chordal replacement and indirect annuloplasty (using coronary sinus devices, radiofrequency-mediated annular remodeling and cinching devices) are in various stages of development. Meanwhile, we do have personal experience using Melody valves as MV replacement using the hybrid approach. Rheumatic fever continues to be the commonest cause of acquired heart disease in the children and adolescent population of most developing countries. Until the early 1980s, the only option for patients with mitral stenosis (MS) uncontrollable by medical therapy was surgery. After several technical modifications balloon mitral valvotomy is a standard therapeutic modality for managing rheumatic mitral stenosis. Patients with sinus rhythm, less gross valve deformity, and a post-balloon mitral valvotomy area >1.75 cm 2 will have better intermediate outcomes. Detailed knowledge of MV pathology will lead to perfect solutions for each individual patient.

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Papillary muscle traction in mitral valve prolapse: Quantitation by two-dimensional echocardiography

Cited by 91 publications

References 29 publications

Floppy Mitral Valve (FMV)/Mitral Valve Prolapse (MVP) and the FMV/MVP Syndrome: Pathophysiologic Mechanisms and Pathogenesis of Symptoms

Floppy Mitral Valve (FMV)/Mitral Valve Prolapse (MVP) and the FMV/MVP Syndrome: Pathophysiologic Mechanisms and Pathogenesis of Symptoms

Floppy Mitral Valve Syndrome

Mitral Valve Pathology: Challenges and Solutions – A Short Overview

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