Floppy Mitral Valve (FMV)/Mitral Valve Prolapse (MVP) and the FMV/MVP Syndrome: Pathophysiologic Mechanisms and Pathogenesis of Symptoms

Boudoulas, Konstantinos Dean; Boudoulas, Harisios

doi:10.1159/000351094

Cited by 30 publications

(60 citation statements)

References 149 publications

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“…2 Sin embargo, existe un subgrupo de pacientes con peor pronóstico, mayor riesgo de complicaciones (insuficiencia mitral, endocarditis infecciosa, arritmias cardíacas, muerte súbita, fenómenos tromboembólicos) y necesidad de cirugía, fundamentalmente aquellos en los que el prolapso de válvula mitral se acompaña de válvulas muy afectadas con insuficiencia mitral significativa, lo cual es muy raro en pediatría. 5 La mayoría de los pacientes se encuentran asintomáticos, aunque el denominado "síndrome del prolapso de la válvula mitral" abarca síntomas, como dolor torácico, mareos, vértigo, palpitaciones y disnea-ortopnea no asociados a cardiopatía isquémica.…”

Section: Discussionunclassified

“…Su prevalencia es del 2-5% de la población general. 2 Aunque se asocia con mucha frecuencia a enfermedades del tejido conectivo (sobre todo, síndrome de Marfan), 3 hábito corporal leptosómico y anomalías torácicas (pectus excavatum), 4 es importante resaltar que puede aparecer en pacientes con fenotipo normal. En la gran mayoría de los pacientes, ocurre sin síntomas y con bajo riesgo de complicaciones, y presenta dolor torácico un 11-15% de estos.…”

Section: Dolor Torácico Asociado a Cambios Electrocardiográficos Isquunclassified

“…En la gran mayoría de los pacientes, ocurre sin síntomas y con bajo riesgo de complicaciones, y presenta dolor torácico un 11-15% de estos. 2 El síndrome de Marfan es una enfermedad del tejido conectivo producida por una alteración en la síntesis de fibrilina, de herencia autosómica dominante y con una prevalencia de 1:5000-10 000 en la población general. 3 Suele asociar alteraciones a nivel esquelético, ocular y cardiovascular; estas últimas son las que determinan el pronóstico vital.…”

Section: Dolor Torácico Asociado a Cambios Electrocardiográficos Isquunclassified

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Dolor torácico asociado a cambios electrocardiográficos isquémicos: prolapso mitral en pediatría. Caso clínico

2015

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Presentación de casos clínicos RESUMENEl dolor torácico es poco frecuente y, por lo general, benigno en pediatría. La etiología cardíaca es más infrecuente aún. Sin embargo, es un motivo de consulta que se asocia a cardiopatía isquémica y crea gran alarma social, incluso en profesionales de la salud. Por tanto, es necesario conocer las causas más frecuentes de este síntoma en el niño, así como de patologías graves que lo pueden provocar y requieren tratamiento urgente. Presentamos un caso clínico de dolor torácico asociado a cambios isquémicos en el electrocardiograma en una paciente con prolapso de válvula mitral y fenotipo MASS (prolapso de válvula mitral, dilatación de raÍz aórtica y alteraciones esqueléticas y cutáneas), revisamos el prolapso de válvula mitral y resaltamos la importancia de conocerlo en el ámbito pediátrico. Palabras clave: dolor torácico, isquemia miocárdica, electrocardiograma, prolapso de válvula mitral, pediatría, Marfan.ABSTRACT Chest pain is rare and usually benign in pediatrics. Cardiac etiology is even rarer. However, it is a symptom associated with ischemic heart disease and it imposes great social alarm, even in health care workers. Therefore, it is necessary to know the most common causes of this symptom in children, as well as serious diseases that can cause it, which require prompt medical attention. We report a case of chest pain associated with ischemic electrocardiographic changes in a patient with mitral valve prolapse and MASS phenotype (mitral valve prolapse, aortic root enlargement, and skeletal and skin alterations), we review the mitral valve prolapse and stress the importance of knowing it in the pediatric setting.

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Section: Discussionunclassified

Section: Dolor Torácico Asociado a Cambios Electrocardiográficos Isquunclassified

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Dolor torácico asociado a cambios electrocardiográficos isquémicos: prolapso mitral en pediatría. Caso clínico

2015

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“…From a genetic perspective, two forms of inheritance have been identified at the moment: the former is an autosomal dominant form with a variable degree of penetration (three gene loci have been identified: chromosome 16, 11 and 13), the latter is transmitted through the X-chromosome [7][8][9][10][11]. Prevalence of FMVS in general population is <1%.…”

Section: Floppy Mitral Valve Syndromementioning

confidence: 99%

Floppy Mitral Valve Syndrome

Minardi¹,

Pulignano²,

Denitza³

et al. 2017

J Cardiovasc Dis Diagn

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“…An elaborate explanation was given by Boudoulas and Boudoulas in (21) about the mechanisms by which mitral valve prolapse can cause thromboembolism. The pathology of the FMV ( floppy mitral valve )differs significantly from the normal mitral valve.…”

Section: **Motor Deficitmentioning

confidence: 99%

Transesophageal Echo Study in Patients With Acute Ischemic Stroke

Mansour

Elzaki

El-Sharkawy

et al. 2014

Zagazig University Medical Journal

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Background: Stroke is one of the major causes of death and disability and due to the high mortality and morbidity rates associated with stroke ,it is becoming a major community health problem worldwide. It has been estimated that cardiogenic emboli are a source of transient ischemic attack (TIA) or stroke in 20% to 40% of all cases. Transesophageal echocardiography (TEE) has been proven superior to transthoracic echocardiography (TTE) for the detection of potential sources of cardiac embolism in patients with previous stroke. In particular, the additional value of TEE in the patients above 45 years of age, in whom TEE is still far from routine procedure, was evaluated. In addition, emphasis was placed on therapeutic consequences, ie, the indication for anticoagulation, based on the results of TEE. Aim of the work : The aim of our study is to evaluate the role of TEE (transesophagealecho) to find indications of anticoagulation despite false absence of its benefit by clinical and transthoracicecho (TTE) examination. Patient and methods:The study was conducted in Zagazig university hospitals and included 100 patients diagnosed with ischemic stroke The diagnosis of stroke was made based on clinical data and brain CT. A full TEE was done and the presence of the following potential sources of embolism was specifically examined (a)left atrial spontaneous echo contrast and thrombus , (b)Impaired Left atrial appendage velocity and the presence of LAA (Left atrial appendage )thrombi , (c)Atheroma in the thoracic aorta, (d)Patent foramen ovale and atrial septal aneurysm (e) others, including valvular vegetations and intracardiac masses . Results:Among the different age groups studied , the prevalence of PFO and MVP (mitral valve prolapse) were highest in patients ˂ 45 years old while the prevalence of complex aortic atheroma was highest in patients ˃45 years old .Risk of stroke recurrence was highest in patients with complex aortic atheroma .Among patients with dyslipidemia,prevalance of ischemic stroke was highest in those older than 45 years old and was significantly higher in low HDL (high density lipoprotein ) (˂40 mg/dl ) and high cholesterol (˃200 mg/dl) group.Furthermore, the risk of stroke recurrence was significantly higher in patients with hypercholesterolemia. Conclusion: TEE has proved to be a very useful tool in diagnosing causes of ischemic stroke .The benefit was not only seen in young age (˂45 years old), but also in those in older age groups .

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Floppy Mitral Valve (FMV)/Mitral Valve Prolapse (MVP) and the FMV/MVP Syndrome: Pathophysiologic Mechanisms and Pathogenesis of Symptoms

Cited by 30 publications

References 149 publications

Dolor torácico asociado a cambios electrocardiográficos isquémicos: prolapso mitral en pediatría. Caso clínico

Dolor torácico asociado a cambios electrocardiográficos isquémicos: prolapso mitral en pediatría. Caso clínico

Floppy Mitral Valve Syndrome

Transesophageal Echo Study in Patients With Acute Ischemic Stroke

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