Papillary cystadenocarcinoma of the hard palate

Abstract

SUMMARYPapillary cystadenocarcinoma (PCC) is an uncommon malignant tumour of the salivary gland, sometimes involving the minor salivary gland. Previously this entity was classified as an atypical type of adenocarcinoma, malignant papillary cystadenoma, low-grade papillary adenocarcinoma or mucus producing adenopapillary carcinoma. PCC is a glandular tumour with an indolent biological behaviour characterised by cysts and papillary endophytic projections. We report two cases of PCC involving the minor salivary gland of the hard palate. Both the patients presented with a swelling in the palate with difficulty in chewing. MRI revealed an extensively destructive lesion involving hard palate, alveolar ridge and maxillary antrum. Clinical and radiological features suggested the malignant nature of the lesion. Histopathology of incisional biopsy revealed tumour proliferation in a multicystic pattern, with extensive papillary proliferation. Diverse and cellular cytomorphology, and cellular and nuclear pleomorphism with few mitotic figures were the prominent features. Both the lesions were confirmed as PCC. BACKGROUND

A Rare Distant Metastasis of Papillary Cystadenocarcinoma Arising from Maxillary Gingiva

“…Ectopic salivary gland tissue has been reported in a wide variety of locations, including the maxilla and mandible. Maxillary gingiva tumor as in the present case is extremely rare in minor salivary gland cystadenocarcinoma [4,5,8]. Pollet et al [6] reported relatively high-grade papillary cystadenocarcinoma of the tongue with local and regional recurrence 6 months after partial glossectomy and bilateral neck dissection.…”

“…This disease is more commonly observed in the major salivary glands (65%) and occurs most often in the parotid gland (95%) [ 1 , 2 ]. Papillary cystadenocarcinoma arising from the sublingual glands is extremely rare and is found in the lip, buccal mucosa, palate, tongue, and retromolar trione [ 3 , 4 , 5 , 6 , 7 , 8 ]. Ectopic salivary gland tissue has been reported in a wide variety of locations, including the maxilla and mandible.…”

“…Papillary cystadenocarcinoma is an uncommon malignant salivary gland tumor [ 1 , 2 , 3 ], sometimes involving the minor salivary gland [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Papillary cystadenocarcinoma is characterized macroscopically as a cystic and solid tumor with papillary growth.…”

Lymphomatous Papillary Cystadenoma: Clinical and Histological features of one case

“…Tiene una marcada predilección por la glándula parótida y los ganglios intraparotideos. Sin embargo, ha sido reportada, aunque con poca frecuencia, en glándula submandibular y glándula salivales menores [29][30][31][32][33] . Sin embargo, existen casos de cistadenoma que afecta a otros sitios, como los labios, mejilla, región posterior de la lengua, paladar, área retromolar también se han descrito 14,15,[34][35][36][37][38][39] .…”