Paper transducers to detect plasmon variations in colorimetric nanoparticle biosensors

Russell, Steven M.; Rica, Roberto de la

doi:10.1016/j.snb.2018.05.052

Cited by 27 publications

(23 citation statements)

References 24 publications

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“…The second configuration leverages the camera of a smartphone to read signals. This makes it possible to perform quantitative measurements using a piece of instrumentation that is easily available at any point of healthcare [ 35 ]. Nanostructured materials have revolutionized the field of optical sensors thanks to the outstanding physical properties afforded by the nanoscale morphology.…”

Section: Biosensor Configurationmentioning

confidence: 99%

Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

et al. 2022

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Severe infections can cause a dysregulated response leading to organ dysfunction known as sepsis. Sepsis can be lethal if not identified and treated right away. This requires measuring biomarkers and pathogens rapidly at the different points where sepsis care is provided. Current commercial approaches for sepsis diagnosis are not fast, sensitive, and/or specific enough for meeting this medical challenge. In this article, we review recent advances in the development of diagnostic tools for sepsis management based on micro- and nanostructured materials. We start with a brief introduction to the most popular biomarkers for sepsis diagnosis (lactate, procalcitonin, cytokines, C-reactive protein, and other emerging protein and non-protein biomarkers including miRNAs and cell-based assays) and methods for detecting bacteremia. We then highlight the role of nano- and microstructured materials in developing biosensors for detecting them taking into consideration the particular needs of every point of sepsis care (e.g., ultrafast detection of multiple protein biomarkers for diagnosing in triage , emergency room, ward, and intensive care unit; quantitative detection to de-escalate treatment; ultrasensitive and culture-independent detection of blood pathogens for personalized antimicrobial therapies; robust, portable, and web-connected biomarker tests outside the hospital). We conclude with an overview of the most utilized nano- and microstructured materials used thus far for solving issues related to sepsis diagnosis and point to new challenges for future development. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s00604-022-05171-2.

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Section: Biosensor Configurationmentioning

confidence: 99%

Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

et al. 2022

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“…Suspensions of gold nanoparticles blocks pattern recognition, while aggregations of nanoparticles do not, so generating a signal. This easy to use and cheap platform can be ideal to develop mobile POC biosensors for diagnostics [ 75 ].…”

Section: Poc Tools For Personalized Medicinementioning

confidence: 99%

“… Schematic representation of the paper-based device developed by Russell and de la Rica. Modified from [ 75 ]. ( A ) A pattern is printed on filter paper; the presence of non-aggregated gold nanoparticles in suspension block pattern recognition the app, and no signal is generated; while aggregated nanoparticles do not impede pattern recognition ( B ) the methods is based the competitive immunoassay on magnetic beads that can cause the aggregation of gold nanoparticles.…”

Section: Figurementioning

confidence: 99%

Key Enabling Technologies for Point-of-Care Diagnostics

Primiceri

Chiriaco

Notarangelo

et al. 2018

Sensors

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A major trend in biomedical engineering is the development of reliable, self-contained point-of-care (POC) devices for diagnostics and in-field assays. The new generation of such platforms increasingly addresses the clinical and environmental needs. Moreover, they are becoming more and more integrated with everyday objects, such as smartphones, and their spread among unskilled common people, has the power to improve the quality of life, both in the developed world and in low-resource settings. The future success of these tools will depend on the integration of the relevant key enabling technologies on an industrial scale (microfluidics with microelectronics, highly sensitive detection methods and low-cost materials for easy-to-use tools). Here, recent advances and perspectives will be reviewed across the large spectrum of their applications.

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“…Moreover, cellulose paper can be easily functionalized, allowing immobilization with antibodies, or enzymes, or combination with magnetic nanoparticles and noble metal nanoparticles to enhance biosensor performance [ 16 ]. In recent years, paper-based sensors have been developed as paper-based electrochemical sensors [ 17 ], colorimetric sensors [ 18 ], microbial fuel cells [ 19 ], and flexible sensors [ 20 ]. They are tested by optical and electrochemical methods, but the above methods have some defects, such as the error of test results caused by the illumination difference, and the complicated manufacturing process.…”

Section: Introductionmentioning

confidence: 99%

A Novel NiFe2O4/Paper-Based Magnetoelastic Biosensor to Detect Human Serum Albumin

Guo

Liu

et al. 2020

Sensors

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For the first time, a novel NiFe2O4/paper-based magnetoelastic (ME) biosensor was developed for rapid, sensitive, and portable detection of human serum albumin (HSA). Due to the uniquely magnetoelastic effect of NiFe2O4 nanoparticles and the excellent mechanical properties of the paper, the paper-based ME biosensor transforms the surface stress signal induced by the specific binding of HSA and antibody modified on the paper into the electromagnetic signal. The accumulated binding complex generates a compressive stress on the biosensor surface, resulting in a decrease in the biosensor’s static magnetic permeability, which correlates to the HSA concentrations. To improve the sensitivity of the biosensor, the concentration of NiFe2O4 nanofluid and the impregnated numbers of the NiFe2O4 nanofluid-impregnated papers were optimized. The experimental results demonstrated that the biosensor exhibited a linear response to HSA concentrations ranging from 10 μg∙mL−1 to 200 μg∙mL−1, with a detection limit of 0.43 μg∙mL−1, which is significantly lower than the minimal diagnosis limit of microalbuminuria. The NiFe2O4/paper-based ME biosensor is easy to fabricate, and allows the rapid, highly-sensitive, and selective detection of HSA, providing a valuable analytical device for early monitoring and clinical diagnosis of microalbuminuria and nephropathy. This study shows the successful integration of the paper-based biosensor and the ME sensing analytical method will be a highly-sensitive, easy-to-use, disposable, and portable alternative for point-of-care monitoring.

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Paper transducers to detect plasmon variations in colorimetric nanoparticle biosensors

Cited by 27 publications

References 24 publications

Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

Key Enabling Technologies for Point-of-Care Diagnostics

A Novel NiFe2O4/Paper-Based Magnetoelastic Biosensor to Detect Human Serum Albumin

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