Paper chromatography of urinary indoles extracted under alkaline and acid conditions

Sprince, Herbert; Parker, Clarence M.; Dawson, John T.; Jameson, Dorothy; Dohan, F. C.

doi:10.1016/s0021-9673(01)99291-x

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…Cyclic dipeptides are typically formed during heat treatment, and cyclo-Pro-Val has been identified in various food products such as coffee and cocoa. , Neither cyclo-Pro-Val nor pGlu-Pro has to our knowledge been found as dietary markers in urine before. 3-Indoleacetyl-glucuronide is a microbial tryptophan metabolite that has previously been reported to be present in urine of healthy subjects . The tryptophan content is high in animal protein, and the finding of 3-indoleacetyl-glucuronide may therefore also reflect differences in the protein sources between the diets.…”

Section: Discussionmentioning

confidence: 99%

“…3-Indoleacetyl-glucuronide is a microbial tryptophan metabolite that has previously been reported to be present in urine of healthy subjects. 50 The tryptophan content is high in animal protein, 46 and the finding of 3-indoleacetyl-glucuronide may therefore also reflect differences in the protein sources between the diets. Octanoylglucuronide has previously been reported in urine from children on a diet high in medium chain fatty acid triglycerides.…”

Section: Metabolites In the Pls-da Model Characterizing The Add Dietmentioning

confidence: 99%

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Untargeted Metabolomics as a Screening Tool for Estimating Compliance to a Dietary Pattern

Andersen¹,

Rinnan²,

et al. 2014

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There is a growing interest in studying the nutritional effects of complex diets. For such studies, measurement of dietary compliance is a challenge because the currently available compliance markers cover only limited aspects of a diet. In the present study, an untargeted metabolomics approach was used to develop a compliance measure in urine to distinguish between two dietary patterns. A parallel intervention study was carried out in which 181 participants were randomized to follow either a New Nordic Diet (NND) or an Average Danish Diet (ADD) for 6 months. Dietary intakes were closely monitored over the whole study period, and 24 h urine samples as well as weighed dietary records were collected several times during the study. The urine samples were analyzed by UPLC-qTOF-MS, and a partial least-squares discriminant analysis with feature selection was applied to develop a compliance model based on data from 214 urine samples. The optimized model included 52 metabolites and had a misclassification rate of 19% in a validation set containing 139 samples. The metabolites identified in the model were markers of individual foods such as citrus, cocoa-containing products, and fish as well as more general dietary traits such as high fruit and vegetable intake or high intake of heat-treated foods. It was easier to classify the ADD diet than the NND diet probably due to seasonal variation in the food composition of NND and indications of lower compliance among the NND subjects. In conclusion, untargeted metabolomics is a promising approach to develop compliance measures that cover the most important discriminant metabolites of complex diets.

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Section: Discussionmentioning

confidence: 99%

Section: Metabolites In the Pls-da Model Characterizing The Add Dietmentioning

confidence: 99%

Untargeted Metabolomics as a Screening Tool for Estimating Compliance to a Dietary Pattern

Andersen¹,

Rinnan²,

et al. 2014

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show abstract

“…Two of the Ehrlich-positive spots occurring more frequently in schizophrenic urine have been tentatively identified as indole acetamide, presumably formed from indole acetylglucuronic acid by ammonolysis (406), and 6-hydroxyskatole sulfate (407)(408)(409). 5-and 7-Hydroxyskatoles accompany the 6-isomer in the same spot (410,411).…”

Section: P 68-69)mentioning

confidence: 99%

The Biochemistry of the Functional Psychoses

Weil‐Malherbe

1967

Advances in Enzymology - And Related Areas of Molecular Biology

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“…New paper-chromatographic methods have also been described for indoles (653,1477), nitroanthrimidines (270), quinoline-A7-oxides (1158), pyridylcarbinol-V-oxide and related compounds (1651), substituted trinitrobenzenes (303,304), cyanamide derivatives (1564), substituted cinnolines (571), aliphatic diamines (1150), and alkylammonium salts (536, 758).…”

Section: Carbohydratesmentioning

confidence: 99%

Chromatography

Heftmanń¹

1964

Anal. Chem.

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Paper chromatography of urinary indoles extracted under alkaline and acid conditions

Cited by 11 publications

References 15 publications

Untargeted Metabolomics as a Screening Tool for Estimating Compliance to a Dietary Pattern

Untargeted Metabolomics as a Screening Tool for Estimating Compliance to a Dietary Pattern

The Biochemistry of the Functional Psychoses

Chromatography

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