Paper biosensors for detecting elevated IL-6 levels in blood and respiratory samples from COVID-19 patients

Adrover-Jaume, Cristina; Alba-Patiño, Alejandra; Clemente, Antonio; Santopolo, Giulia; Vaquer, Andreu; Russell, Steven M.; Barón, Enrique; Campo, María del Mar González del; Ferrer, Joana M.; Berman-Riu, María; García-Gasalla, Mercedes; Aranda, María P.; Borges, Marcio; Rica, Roberto de la

doi:10.1016/j.snb.2020.129333

Cited by 53 publications

(32 citation statements)

References 44 publications

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“…Adrover-Jaume et al developed a paper-based colorimetric immunosensor for detection of IL-6 in blood and respiratory samples from COVID-19 patients ( Fig. 2 C) [ 118 ]. A reservoir was created by using paraffin to define hydrophobic barrier on a square piece of paper and filled with polystyrene sulfonate (PSS).…”

Section: Recent Applications Of Paper-based Analytical Devices For Virus Detectionmentioning

confidence: 99%

“… Target Fabrication Method Detection Method Label/Biorecognition element Linear Range LOD Ref. Hepatitis B virus (HBV) screen printing DPV Label free/acpcPNA 0.05-100 nM 1.45 pM [ 77 ] HIV type 1(HIV-1) p24 antigen wax printing Colorimetric anti-HIV-1 p24/anti-HIV-1 p24-HRP) Not specified 0.03 ng mL −1 [ 78 ] anti-SARV-CoV-2 IgG LFA Fluorescence lanthanide-doped polysterene nanoparticles (LNPs) Not specified N/A [ 113 ] avian influenza viruses (AIV), H9N2, H1N1, H5N9 LFA chemiluminescent PSNPs/antibody/HRP Not specified 10 3.5 10 2.5 10 4 EID 50 /mL [ 114 ] Porcine epidemic diarrhea virus (PEDV) LFA Fluorescence AuNPs/LFIS Not specified 0.055 μg mL -1 [ 40 ] Pseudorabies virus (PRV)-gE-Ab LFA Fluorescence Latex beads/ Not specified N/A [ 115 ] IL-6 Wax printing Colorimetric AuNPs-antibody 10 -3 -10 2 pg mL -1 10 -3 pg mL -1 in PBS, 1.3 pg mL -1 in blood [ 118 ] SARS-CoV-2 antibodies IgG and IgM Wax printing and screen printing SWV GO/spike protein receptor-binding domain (SP RBD) of SARS-CoV-2 1-10 3 ng mL -1 1 ng mL -...…”

Section: Recent Applications Of Paper-based Analytical Devices For Virus Detectionmentioning

confidence: 99%

“…Among the many applications, colorimetric LFAs for virus detection have become common with improved sensitivity and specificity owing to recent improvements in both labels and flow control. Among aforementioned colorimetric LFAs based on antibody as a recognition element, the immunosensor developed by Adrover-Jaume et al for detection of IL-6 is promising as POC diagnosis for future viral diseases due to its applications in blood and respiratory samples from COVID-19 patients and fast response time (less than 10 min) [ 118 ]. However, LOD could be further improved and stability studies should be performed to be used in possible pandemics in the future.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

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Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Özer

Henry

2021

TrAC Trends in Analytical Chemistry

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The importance of user-friendly, inexpensive, sensitive, and selective detection of viruses has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) pandemic. Among the analytical tools, paper-based devices (PADs) have become a leading alternative for point-of-care (POC) testing. In this review, we discuss the recent development strategies and applications in nucleic acid-based, antibody/antigen-based and other affinity-based PADs using optical and electrochemical detection methods for sensing viruses. In addition, advantages and drawbacks of presented PADs are identified. Current state and insights towards future perspectives are presented regarding developing POC diagnosis platform for COVID-19. This review considers state-of-the-art technologies for further development and improvement in PADs performance for virus detection.

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Section: Recent Applications Of Paper-based Analytical Devices For Virus Detectionmentioning

confidence: 99%

Section: Recent Applications Of Paper-based Analytical Devices For Virus Detectionmentioning

confidence: 99%

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

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Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Özer

Henry

2021

TrAC Trends in Analytical Chemistry

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“…The majority of currently developed sensors for the rapid detection of communicable diseases are based on immunosensor‐based technologies. [ 108, 113, 116, 146 ] These include, but are not limited to, electrochemical, optical, piezoelectric, colorimetric, and magnetic platforms to detect specifically targeted analytes. The primary sample sources are swabs and blood samples.…”

Section: Biodiagnostics and Body Monitoringmentioning

confidence: 99%

“…Only a minor portion of the developed technologies are portable and can serve as a potential point of care (POC)‐based sensor test. [ 103, 107, 112, 113, 116, 147‐149 ] Furthermore, none of these reported systems is a specific personal wearable device for communicable diseases.…”

Section: Biodiagnostics and Body Monitoringmentioning

confidence: 99%

Biointerfaced sensors for biodiagnostics

Zohar

Khatib

Omar

et al. 2021

VIEW

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Biointerfaced sensors have emerged as a new paradigm for medical applications that require an interface and/or intimate contact with biological components/systems such as cells, tissues, and whole organs. This article provides a review of the concept, design, and device characteristics of biointerfaced sensors needed for successful implementation of biodiagnostics and monitoring. It begins by presenting and discussing the different considerations that arise from artificial interfaces with different biological environments. It then explores the main strategies for sensor and material design, while highlighting the required chemistry, structure, and mechanical properties needed to maintain an unperturbed interface with the surrounding biological environment. Finally, the review discusses successful state‐of‐the‐art demonstrations of body monitoring and biodiagnostics, focusing on the brain, heart, muscles, skin, teeth, and other tissues for medical purposes. Insights, perspectives, and recommendations for future research are presented.

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Polymer Components for Paper‐Based Analytical Devices

Campo

Vaquer

Rica

2022

Adv Materials Technologies

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In recent years, paper has become an essential substrate material for developing different types of sensors, from wearable devices to single‐use test strips and biosensors. In parallel, a polymer‐based toolbox has emerged in order to add additional functions to these paper‐based analytical devices. In this article, examples are compiled from the recent literature showing microfluidic systems based on printing impermeable polymer barriers with different methods as well as the implementation of electrochemical, fluorescent, and colorimetric polymer‐based transducers in paper‐based analytical platforms. Externally actuated or dissolvable polymer valves and reservoirs, analyte concentrators, and separation devices, as well as polymer‐based recognition elements (molecularly imprinted polymers) printed on paper substrates are also reviewed. The search has revealed a plethora of possibilities for developing complex lab‐on‐chip devices implementing different polymer‐based components in them. The ability of patterning these polymers with common printing methods that do not require specialized facilities paves the way for mass producing this kind of advanced paper‐based analytical device.

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Paper biosensors for detecting elevated IL-6 levels in blood and respiratory samples from COVID-19 patients

Cited by 53 publications

References 44 publications

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Biointerfaced sensors for biodiagnostics

Polymer Components for Paper‐Based Analytical Devices

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