Paper-based microfluidic devices for food adulterants: Cost-effective technological monitoring systems

Ray, Rohitraj; Prabhu, Anusha; Prasad, Dinesh; Garlapati, Vijay Kumar; Aminabhavi, Tejraj M.; Mani, Naresh Kumar; Simal-Gándara, Jesús

doi:10.1016/j.foodchem.2022.133173

Cited by 41 publications

(16 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In resource-constrained settings, distance-based nucleic acid assays using microfluidic paper-based analytical devices (μPAD) and other cellulose-based assays [60][61][62][63][64][65][66] offer great potential for the rapid and early diagnosis of diseases and detecting analytes. These devices measure the distance as a digital readout to quantify the concentration of nucleic acids.…”

Section: Distance-based Assaymentioning

confidence: 99%

DNA compaction enhances the sensitivity of fluorescence-based nucleic acid assays: a game changer in point of care sensors?

Sudarsan

Prabhu

Prasad

et al. 2023

Analyst

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Distance-based Assaymentioning

confidence: 99%

DNA compaction enhances the sensitivity of fluorescence-based nucleic acid assays: a game changer in point of care sensors?

Sudarsan

Prabhu

Prasad

et al. 2023

Analyst

Self Cite

View full text Add to dashboard Cite

show abstract

“…The samples were spiked with 0.002, 0.01, 0.06, 0.5, 1, and 2.5% (wt/wt) concentrations of metanil yellow. LODs were 0.5% (wt/wt) for curcumin and 0.25% (wt/wt) for pigeon peas (Ray et al, 2022).…”

Section: Detection With µPads and New Technology Adoptionsmentioning

confidence: 99%

Evaluation of food μPADs with the new tech perspectives and future prospects

Okutan Arslan,

Trabzon

2023

eFood

View full text Add to dashboard Cite

Food microfluidic paper‐based analytical devices (µPADs) are powerful tools to create total analysis systems and have long been demonstrated to be useful for safety and quality applications. Thanks to new technological innovations food µPADs offer exciting new possibilities. This review introduces how µPADs are obtained from chromatography, filter, or office papers and detect analytes from a food sample. We introduce the most current developments in the use of µPADs with an emphasis on paper types, adapted new technologies, and detection limits. Classifications are also made on food µPADs according to applied innovations and adapted novel technologies. In the first section, simple forms of µPADs for the detection of pathogen, mycotoxin, pesticides, and other food components are discussed with technical details. Then, we introduce multisensing approaches for high throughput analysis and a concise summary will be given. In the case of three‐dimensional (3D) µPADs, the use of 3D is discussed and compared to 2D µPADs in terms of its advantageous with the example of a food colorant test device. In the following section, smartphone adoption to µPADs is introduced in detail with eight different assay examples. Centrifugal platform for nickel assay is demonstrated as an enabling approach with shortened assay times by rotational velocity. The potential of user‐friendly hybrid devices is also summarized in the last part. Finally, we present an outlook to underline the opportunities created by smartphone‐based and intelligent µPADs for food safety and quality with real success perspectives

show abstract

“…Among the platforms utilizing paper, microfluidic paper-based analytical devices (μPADs) stand out as a notable example . The versatile design and cost-effectiveness of μPADs have boosted their utilization in areas like food safety, environmental analyses, and diagnostics . It is also a powerful tool to help implementing diagnostic approaches in countries with inadequate infrastructures .…”

Section: Introductionmentioning

confidence: 99%

Solvent-Assisted Laser Desorption Flexible Microtube Plasma Mass Spectrometry for Direct Analysis of Dried Samples on Paper

Bouza,

Ahlmann,

García-Reyes

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

The present study investigated the potential for solvent-assisted laser desorption coupled with flexible microtube plasma ionization mass spectrometry (SALD-FμTP-MS) as a rapid analytical technique for direct analysis of surface-deposited samples. Paper was used as the demonstrative substrate, and an infrared hand-held laser was employed for sample desorption, aiming to explore cost-effective sampling and analysis methods. SALD-FμTP-MS offers several advantages, particularly for biofluid analysis, including affordability, the ability to analyze low sample volumes (<10 μL), expanded chemical coverage, sample and substrate stability, and in situ analysis and high throughput potential. The optimization process involved exploring the use of viscous solvents with high boiling points as liquid matrices. This approach aimed to enhance desorption and ionization efficiencies. Ethylene glycol (EG) was identified as a suitable solvent, which not only improved sensitivity but also ensured substrate stability during analysis. Furthermore, the addition of cosolvents such as acetonitrile/water (1:1) and ethyl acetate further enhanced sensitivity and reproducibility for a standard solution containing amphetamine, imazalil, and cholesterol. Optimized conditions for reproducible and sensitive analysis were determined as 1000 ms of laser exposure time using a 1 μL solvent mixture of 60% EG and 40% acetonitrile (ACN)/water (1:1). A mixture of 60% EG and 40% ACN/water (1:1) resulted in signal enhancements and relative standard deviations of 12, 20, and 13% for the evaluated standards, respectively. The applicability of SALD-FμTP-MS was further evaluated by successfully analyzing food, water, and biological samples, highlighting the potential of SALD-FμTP-MS analysis, particularly for thermolabile and polarity diverse compounds.

show abstract

Paper-based microfluidic devices for food adulterants: Cost-effective technological monitoring systems

Cited by 41 publications

References 73 publications

DNA compaction enhances the sensitivity of fluorescence-based nucleic acid assays: a game changer in point of care sensors?

DNA compaction enhances the sensitivity of fluorescence-based nucleic acid assays: a game changer in point of care sensors?

Evaluation of food μPADs with the new tech perspectives and future prospects

Solvent-Assisted Laser Desorption Flexible Microtube Plasma Mass Spectrometry for Direct Analysis of Dried Samples on Paper

Contact Info

Product

Resources

About