Paper-based closed Au-Bipolar electrode electrochemiluminescence sensing platform for the detection of miRNA-155

Wang, Fangfang; Fu, Cuiping; Huang, Chuan Zhen; Li, Na; Wang, Yanhu; Ge, Shenguang; Yu, Jinghua

doi:10.1016/j.bios.2019.111917

Cited by 60 publications

(33 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the techniques are limited in the frequency that can be achieved due to the time constant BPEs because paper-based electrodes tend to have higher internal resistance, and therefore, advancements in the field of BPE-ePADs have focused on improving sensitivity through the addition of NPs 39,66 or amplification reactions to the BPE. 46 Enrichment of small molecules, proteins, and nucleic acids by electrokinetic focusing has also been accomplished by bipolar electrochemistry in an ePAD.…”

Section: Methods To Obtain Periodic Signals From Bpesmentioning

confidence: 99%

“…Advancements to BPE-ePADs made over the last two years include an amplification scheme for nucleic acid detection 66 and the integration of an electrochromic reporting reaction 87 into a BPE-ePAD. These recent developments are summarized below.…”

Section: Methods To Obtain Periodic Signals From Bpesmentioning

confidence: 99%

“…However, in resistance. 10,36,39,43,46,66 The integration of electrochemical aptasensors with bipolar electrochemistry holds promise for multiplexed detection of several classes of analytes.…”

Section: Sensing Mechanisms In Which Biorecognition Leads To a Changementioning

confidence: 99%

See 2 more Smart Citations

Recent Advancements in Bipolar Electrochemical Methods of Analysis

Rahn

Anand

2020

Anal. Chem.

View full text Add to dashboard Cite

The goal of this review is to provide an overview of the advancements made in the field of bipolar electrochemistry over the past 2 years, with an emphasis on analysis. Bipolar electrodes (BPEs) are versatile, and in electroanalysis, they have been used extensively to screen electrocatalysts(1−4) and to sense biomarkers.(5−10) Their ability to modulate local electric fields lends them to the manipulation of cells and to the enrichment and separation of analytes.(11−17) Finally, by virtue of the polar and often graded profile of the interfacial potential across BPEs, they provide a platform for synthesis of Janus particles, useful as sensors and as microswimmers(18−22) and other materials with compositional gradients.(23,24) BPEs are particularly well-suited to analytical challenges that demand multiplexing or amenability to point-of-need (PON) application because even large arrays of BPEs can be controlled with simple equipment yet yield quantitative information about a system. In this review, we discuss recent progress in reactions that transduce current to a visible signal, sensing mechanisms, bipolar electrochemical cell design, integration of bipolar electrochemistry with spectroscopic techniques, BPEs at the nanoscale, and the application of BPEs to electrokinetics and materials preparation. Throughout the discussion, we identify promising trends, innovative directions, and remaining challenges in the field. Disciplines Disciplines Analytical Chemistry Comments Comments

show abstract

Section: Methods To Obtain Periodic Signals From Bpesmentioning

confidence: 99%

Section: Methods To Obtain Periodic Signals From Bpesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advancements in Bipolar Electrochemical Methods of Analysis

Rahn

Anand

2020

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…Currently, simple and sensitive methods for miRNAs detection are still highly demanded. Figure 10 illustrates a novel [Ru(bpy) 3 ] 2+ -based ECL immunosensor for rapid and sensitive detection of miRNA-155 utilizing a microfluidic system based on a paper-based closed Au-bipolar electrode (BPE) [ 166 ]. Wax-printing technology, screen printing method and in-situ AuNPs growth were used for the microfluidic platform fabrication.…”

Section: Ecl Dna Biosensorsmentioning

confidence: 99%

“… Scheme of ECL biosensor development for the detection of miRNA-155 using a microfluidic system based on a paper-based closed Au-bipolar electrode proposed by Yu et al [ 166 ]. Reproduced and adapted with permission of Elsevier.…”

Section: Figures Scheme and Tablesmentioning

confidence: 99%

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

et al. 2020

View full text Add to dashboard Cite

Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the particular case of sensing applications, ECL biosensor unites the benefits of the high selectivity of biological recognition elements and the high sensitivity of ECL analysis methods. Hence, it is a powerful analytical device for sensitive detection of different analytes of interest in medical prognosis and diagnosis, food control and environment. These wide range of applications are increased by the introduction of screen-printed electrodes (SPEs). Disposable SPE-based biosensors cover the need to perform in-situ measurements with portable devices quickly and accurately. In this review, we sum up the latest biosensing applications and current progress on ECL bioanalysis combined with disposable SPEs in the field of bio affinity ECL sensors including immunosensors, DNA analysis and catalytic ECL sensors. Furthermore, the integration of nanomaterials with particular physical and chemical properties in the ECL biosensing systems has improved tremendously their sensitivity and overall performance, being one of the most appropriates research fields for the development of highly sensitive ECL biosensor devices.

show abstract

Bipolar Electrochemistry

Bouffier¹,

Zigah

Šojić

et al. 2021

Encyclopedia of Electrochemistry

View full text Add to dashboard Cite

Bipolar electrochemistry is a technique that involves two opposite chemical processes, namely an oxidation and a reduction, occurring simultaneously on the surface of a conducting object, usually without connection to a power supply. The basic phenomenon has already been described and used for many decades but regained a lot of interest in recent years, thanks to several attractive features for developing new applications in various areas ranging from materials science and analytical chemistry to catalysis and even life science. Consequently, bipolar electrochemistry has experienced a substantial growth in the number of users and publications. This is mostly due to several advantages over classic electrochemistry, such as the absence of an ohmic contact, the generation of a directional gradient of electroactivity on the object, and the possibility to address simultaneously thousands of objects, which opens the door for high throughput screening of (electro)chemical properties. Also, some features of this "wireless" electrochemistry allow performing experiments that cannot be achieved with a classic electrochemical setup. Last but not least, only rather low-cost equipment is needed. The objective of the present contribution is to introduce first some fundamental aspects of bipolar electrochemistry, and then to illustrate its different developments, highlighting not only the historic landmark achievements, but also the most recent findings, especially in the context of micro-and nanoscience. The chapter will illustrate the singularities and advantages of this straightforward approach and hopefully convince the reader of the power of this interesting electrochemical concept.

show abstract

Paper-based closed Au-Bipolar electrode electrochemiluminescence sensing platform for the detection of miRNA-155

Cited by 60 publications

References 45 publications

Recent Advancements in Bipolar Electrochemical Methods of Analysis

Recent Advancements in Bipolar Electrochemical Methods of Analysis

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

Bipolar Electrochemistry

Contact Info

Product

Resources

About