Paper-Based Bipolar Electrochemistry

Renault, Christophe; Scida, Karen; Knust, Kyle N.; Fosdick, Stephen E.; Crooks, Richard M.

doi:10.5229/jecst.2013.4.4.146

Cited by 24 publications

(8 citation statements)

References 34 publications

(29 reference statements)

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“…For example, cancer biomarkers have been detected on a closed indium-doped tin oxide (ITO) BE array biochip by parallel screening analysis with a simple visual ECL readout (209). Among the different analytical trends, paper-based bipolar ECL devices attracted great interest because they are versatile and inexpensive (213)(214)(215)(216)(217)(218)(219)(220). However, the paper-based bipolar systems exhibit usually a higher resistance than classic metallic electrodes, leading to a lower sensitivity.…”

Section: Optical Transductionmentioning

confidence: 99%

Bipolar Electrochemistry

Bouffier¹,

Zigah

Šojić

et al. 2021

Encyclopedia of Electrochemistry

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Bipolar electrochemistry is a technique that involves two opposite chemical processes, namely an oxidation and a reduction, occurring simultaneously on the surface of a conducting object, usually without connection to a power supply. The basic phenomenon has already been described and used for many decades but regained a lot of interest in recent years, thanks to several attractive features for developing new applications in various areas ranging from materials science and analytical chemistry to catalysis and even life science. Consequently, bipolar electrochemistry has experienced a substantial growth in the number of users and publications. This is mostly due to several advantages over classic electrochemistry, such as the absence of an ohmic contact, the generation of a directional gradient of electroactivity on the object, and the possibility to address simultaneously thousands of objects, which opens the door for high throughput screening of (electro)chemical properties. Also, some features of this "wireless" electrochemistry allow performing experiments that cannot be achieved with a classic electrochemical setup. Last but not least, only rather low-cost equipment is needed. The objective of the present contribution is to introduce first some fundamental aspects of bipolar electrochemistry, and then to illustrate its different developments, highlighting not only the historic landmark achievements, but also the most recent findings, especially in the context of micro-and nanoscience. The chapter will illustrate the singularities and advantages of this straightforward approach and hopefully convince the reader of the power of this interesting electrochemical concept.

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Section: Optical Transductionmentioning

confidence: 99%

Bipolar Electrochemistry

Bouffier¹,

Zigah

Šojić

et al. 2021

Encyclopedia of Electrochemistry

View full text Add to dashboard Cite

show abstract

“…Also, the localization of the ECL reaction can be controlled in a 2-dimensional space on the perimeter of a square bipolar electrode by adjusting the electric field direction [30]. More recently, in an effort to limit the fabrication cost of BPE analytical platforms that are very often based on microfabrication techniques and incorporate expensive metal electrodes, paper-based devices were proposed [31,32].…”

Section: Open-configuration Ecl/bpementioning

confidence: 99%

Advances in bipolar electrochemiluminescence for the detection of biorelevant molecular targets

Bouffier

Manojlović

Kuhn

et al. 2019

Current Opinion in Electrochemistry

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“…Using a traditional screen-printing process, carbon-based electrodes can be printed directly onto cellulose paper to form electrochemical analytical devices. 107 By printing multiple designs on paper, Renault et al demonstrated the use of a single pair of driving electrodes to control 18 separate screen-printed bipolar electrodes. Each of these bipolar electrodes reads out the electrochemical state, demonstrating the multiplexing capabilities of screenprinted electrochemical microfluidic devices.…”

Section: Screen Printingmentioning

confidence: 99%

Paper-based assays for urine analysis

et al. 2017

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A transformation of the healthcare industry is necessary and imminent: hospital-centered, reactive care will soon give way to proactive, person-centered care which focuses on individuals' well-being. However, this transition will only be made possible through scientific innovation. Next-generation technologies will be the key to developing affordable and accessible care, while also lowering the costs of healthcare. A promising solution to this challenge is low-cost continuous health monitoring; this approach allows for effective screening, analysis, and diagnosis and facilitates proactive medical intervention. Urine has great promise for being a key resource for health monitoring; unlike blood, it can be collected effortlessly on a daily basis without pain or the need for special equipment. Unfortunately, the commercial rapid urine analysis tests that exist today can only go so far-this is where the promise of microfluidic devices lies. Microfluidic devices have a proven record of being effective analytical devices, capable of controlling the flow of fluid samples, containing reaction and detection zones, and displaying results, all within a compact footprint. Moving past traditional glass- and polymer-based microfluidics, paper-based microfluidic devices possess the same diagnostic ability, with the added benefits of facile manufacturing, low-cost implementation, and disposability. Hence, we review the recent progress in the application of paper-based microfluidics to urine analysis as a solution to providing continuous health monitoring for proactive care. First, we present important considerations for point-of-care diagnostic devices. We then discuss what urine is and how paper functions as the substrate for urine analysis. Next, we cover the current commercial rapid tests that exist and thereby demonstrate where paper-based microfluidic urine analysis devices may fit into the commercial market in the future. Afterward, we discuss various fabrication techniques that have been recently developed for paper-based microfluidic devices. Transitioning from fabrication to implementation, we present some of the clinically implemented urine assays and their importance in healthcare and clinical diagnosis, with a focus on paper-based microfluidic assays. We then conclude by providing an overview of select biomarker research tailored towards urine diagnostics. This review will demonstrate the applicability of paper-based assays for urine analysis and where they may fit into the commercial healthcare market.

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Paper-Based Bipolar Electrochemistry

Cited by 24 publications

References 34 publications

Bipolar Electrochemistry

Bipolar Electrochemistry

Advances in bipolar electrochemiluminescence for the detection of biorelevant molecular targets

Paper-based assays for urine analysis

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