Papaver somniferum (opium poppy).

Haas, L F

doi:10.1136/jnnp.58.4.402

Cited by 6 publications

(3 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lupane betulin, for instance, was firstly isolated in 1788 from birch bark trees, [7] a research 20 years older than the first reports on morphine isolation. [8,9] A diversity of biological activities has been reported regarding TPs, especially those associated to cytotoxic activity. [10,11] The breakthrough of the use of TPs as anticancer agents resulted from the isolation of betulinic acid, ursolic acid and uvaol from Vauquelinia corymbose (Rosaceae) in 1976.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Pereira

Evangelista

Júnior

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

Cheiloclinium cognatum (Miers) A.C.Sm. is an endemic species of Brazilian Cerrado that belongs to Celastraceae family. The phytochemical study of C. cognatum branches led to the identification of ten triterpenoids (TPs), 3β-acyloxyurs-12-ene (1), friedelin (2), β-friedelinol (3), glut-5-en-3β-ol (4), α-amyrin (5), βamyrin (6), β-sitosterol (7), canophyllol (8), 29-hydroxyfriedelan-3-one (9) and friedelane-3β,29-diol (10). TPs 4, 5 and 6 are described for the first Cheiloclinium genus and TPs 8 and 9 were isolated in expressive amounts. Their cytotoxic activities were evaluated against THP-1 and K562 leukemia cell lines. TPs 3 and 5 were the most active, exhibiting lower or similar IC 50 against both cell lines when compared to the controls. Their mechanisms of action were investigated suggesting an intrinsic mitochondrial pathway of apoptosis evidenced by up-regulation of BAK mRNA expression. Chemometric studies indicated that their activities may be related to their molecular size and shape as well as electronic interactions of C-3 hydroxy group with molecular targets.

show abstract

Section: Introductionmentioning

confidence: 99%

“…In fact, TPs have been studied for a long time. The lupane betulin, for instance, was firstly isolated in 1788 from birch bark trees, [7] a research 20 years older than the first reports on morphine isolation [8,9] …”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Pereira

Evangelista

Júnior

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…In 1839 the British successfully waged the Opium War with China to preserve its profitable opium trade. The surgeon William Halstead successfully "treated" a debilitative addiction to cocaine by switching to morphine8 . According to Unani literature, it is used alone or in combination with other medicine as compound formulation like Itrifal Muqawwi Dimagh, Sharbat khashkhash, and khamir-e-khashkhash.etc 9 .…”

mentioning

confidence: 99%

Traditional Uses, Phytochemistry and Pharmacological Activities of Papaver Somniferum With Special Reference of Unani Medicine an Updated Review

Masihuddin

Siddiqui

et al. 2018

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Papaver somniferum commonly known as Khashkhash /Afyon, belongs to family Papaveraceae. It is one of those traditional plants, which have a long history of usage as medicine. The opium poppy (Papaver somniferum) produces some of the most widely used medicinal alkaloids like morphine, codeine, thebain and porphyroxine which are the most important component of this plant. Apart from these alkaloids, opium poppy produces approximately eighty alkaloids belonging to various tetrahydrobenzylisoquinolinederived classes. It has been known for over a century that morphinan alkaloids accumulate in the latex of opium poppy. According to Unani literature, it possesses most important theurapeutic values as modern literature and research studies also prove its therapeutical importance. It is used as analgesic, narcotic, sedative, stimulant as well as nutritive, etc. It is also useful in headache, cough, insomnia, cardiac asthma, and biliary colic. In this paper we have provide a review on habitate, pharmacological actions, phytochemical with special refrence to Unani Medicine. In this review, an attempt is made to explore the complete information of Papaver somniferum including its phytochemistry and pharmacology. Key words: Khashkhash, Biliary colic, Alkaloid, phytochemistry.

show abstract

Toxic Plant Ingestions

Graeme¹

2007

Wilderness Medicine

View full text Add to dashboard Cite

Papaver somniferum (opium poppy).

Cited by 6 publications

References 1 publication

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Traditional Uses, Phytochemistry and Pharmacological Activities of Papaver Somniferum With Special Reference of Unani Medicine an Updated Review

Toxic Plant Ingestions

Contact Info

Product

Resources

About