PAP smear versus colposcopy in symptomatic women and women with suspicious-looking cervix

Rokade, Archana; Kshirsagar, Nitin; Laddad, Manisha

doi:10.4103/jnsbm.jnsbm_145_20

Cited by 2 publications

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“…The primary screening methods for patients with cervical cancer are Papanicolaou smear and colposcopy, which assess the morphology of cervical epithelial cells 27,28 . However, these tests occasionally suffer interviewer and intraviewer variability.…”

Section: Discussionmentioning

confidence: 99%

“…The primary screening methods for patients with cervical cancer are Papanicolaou smear and colposcopy, which assess the morphology of cervical epithelial cells. 27,28 However, these tests occasionally suffer interviewer and intraviewer variability. Similarly, high-risk HPV testing has high sensitivity but low specificity, thereby leading to screening is currently under investigation in cervical cancer research.…”

Section: Discussionmentioning

confidence: 99%

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RNPS1 functions as an oncogenic splicing factor in cervical cancer cells

et al. 2022

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Numerous recent studies suggest that cancer-specific splicing alteration is a critical contributor to the pathogenesis of cancer. RNA-binding protein with serine-rich domain 1, RNPS1, is an essential regulator of the splicing process.However, the defined role of RNPS1 in tumorigenesis still remains elusive. We report here that the expression of RNPS1 is higher in cervical carcinoma samples from The Cancer Genome Atlas (TCGA-cervical squamous cell carcinoma and endocervical adenocarcinoma) compared to the normal tissues. Consistently, the expression of RNPS1 was high in cervical cancer cells compared to a normal cell line. This study shows for the first time that RNPS1 promotes cell proliferation and colony-forming ability of cervical cancer cells. Importantly, RNPS1 positively regulates migration-invasion of cervical cancer cells. Intriguingly, depletion of RNPS1 increases the chemosensitivity against the chemotherapeutic drug doxorubicin in cervical cancer cells. Further, we characterized the genome-wide isoform switching stimulated by RNPS1 in cervical cancer cell. Mechanistically, RNA-sequencing analysis showed that RNPS1 regulates the generation of tumor-associated isoforms of key genes, particularly Rac1b, RhoA, MDM4, and WDR1, through alternative splicing.RNPS1 regulates the splicing of Rac1 pre-mRNA via a specific alternative splicing switch and promotes the formation of its tumorigenic splice variant, Rac1b. While the transcriptional regulation of RhoA has been well studied, the role of alternative splicing in RhoA upregulation in cancer cells is largely unknown. Here, we have shown that the knockdown of RNPS1 in cervical cancer cells leads to the skipping of exons encoding the RAS domain of RhoA, consequently causing decreased expression of RhoA. Collectively, we conclude that the gain of RNPS1 expression may be associated with tumor progression in cervical carcinoma. RNPS1-mediated alternative splicing favors an active Rac1b/ RhoA signaling axis that could contribute to cervical cancer cell invasion and

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

RNPS1 functions as an oncogenic splicing factor in cervical cancer cells

et al. 2022

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“…Oxytocin can be used to encourage labor in some cases of uterine lethargy and as a supplement to other treatments for partial or unavoidable abortions. Oxytocin can be administered in the postpartum period to produce contractions in the third stage of labor and to control postpartum bleeding or hemorrhage [5,6]. Oxytocin seems to have the potential to considerably reduce the amount of energy required to ablate uterine fibroids, as well as reduce treatment duration and increase treatment efficiency [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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et al. 2022

J. Med. Chem. Sci.

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PAP smear versus colposcopy in symptomatic women and women with suspicious-looking cervix

Cited by 2 publications

References 0 publications

RNPS1 functions as an oncogenic splicing factor in cervical cancer cells

RNPS1 functions as an oncogenic splicing factor in cervical cancer cells

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