Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption

Shibata, Katsumi; Fukuwatari, Tsutomu; Higashiyama, Saori; Sugita, Chisa; Azumano, Isao; Onda, Maki

doi:10.1016/j.nut.2013.01.002

Cited by 21 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, since high D(+)-fructose diets can cause infertility, further studies are needed to verify these results and the safety of high D(+)-fructose diets. In addition, we found that the minimum requirement for D(+)-glucose for preventing delayed testicular weight gain of weaning rats was 23% compared to rats fed the AIN-93G diet in previous studies 12–15. This glucose may indicate the minimum requirement for exogenous glucose for weaning rats.…”

Section: Resultsmentioning

confidence: 46%

High D(+)-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+)-Glucose Diet

Shibata

Fukuwatari

2013

Nutr Metab Insights

Self Cite

View full text Add to dashboard Cite

The use of high D(+)-fructose corn syrup has increased over the past several decades in the developed countries, while overweight and obesity rates and the related diseases have risen dramatically. However, we found that feeding a high D(+)-fructose diet (80% D(+)-fructose as part of the diet) to weaning rats for 21 days led to reduced food intake (50% less, P < 0.0001) and thus delayed the weight gains in the body (40% less, P < 0.0001) and testes (40% less, P < 0.0001) compared to the no D(+)-fructose diet. We also challenged a minimum requirement of dietary D(+)-glucose for preventing the adverse effects of D(+)-fructose, such as lower food intake and reduction of body weight and testicular weight; the minimum requirement of D(+)-glucose was ≈23% of the diet. This glucose amount may be the minimum requirement of exogenous glucose for reducing weight gain.

show abstract

Section: Resultsmentioning

confidence: 46%

High D(+)-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+)-Glucose Diet

Shibata

Fukuwatari

2013

Nutr Metab Insights

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is also modified by pantethine, a derivate of vitamin B5 and the active site of CoA. Pantethine pools triglycerides in the body as hepato-visceral and subcutaneous fat instead of storing it in the liver while CoA is used for acetylating and amino acid conjugation in phase II of liver detoxification [64]. In addition, Vitamin B1 or Thiamine deficiencies are commonly found in patients with chronic liver disease [65].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a multicomponent nutraceutical on the normalization of liver functional parameters

Cicero¹

2019

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. The main preventive/therapeutic tool of NAFLD is currently the improvement of lifestyle. The purpose of this study is to evaluate the impact of a combined nutraceutical approach on the clinical and laboratory features of NAFLD patients. We consecutively enrolled 80 NAFLD patients in a double-blind, placebo-controlled, randomized clinical trial. After a 4 weeks stabilization diet period, we randomized them to assume a combined multivitamin/multimineral/botanical nutraceutical (Metaclear TM) 2 tablets per day or an identical placebo for 3 months. Patients were rechecked after further 30 days. Liver parameters significantly improved in the combined nutraceutical treated subjects. In particular, in a generalized linear mixed model with Fatty Liver Index (FLI) as dependent variable a significant period by treatment effect was observed (F-value = 22.5, p<0.001). For the patients treated with the combined nutraceutical, FLI decreased with on average 11.9 units and 13.6 units at the end of treatment and the follow-up visit compared to baseline, respectively. The decrease in FLI from baseline to the end of treatment and to follow-up was on average 5.9 units higher (95%C 3.3-8.4, p<0.001) and 8.6 units higher (95%CI 6.0-11.1, p<0.001) for the combined nutraceutical treated group in comparison to the placebo group, respectively. The short-term treatment with the combined nutraceutical has been associated with a significant improvement of NAFLD biomarkers.

show abstract

“…Also, malnourished prisoners of World War II in Asia reported numbness and burning sensation in their feet, and these symptoms were remedied by the administration of pantothenic acid supplementation (Davenport, Spaide, & Hodges, 1971). Also, the beneficial effect of pantothenic acid has been shown in the maintenance of healthy skin and in wound healing processes (Ebner, Heller, Rippke, & Tausch, 2002; Kelly, 2011; Shibata et al, 2013; Weimann & Hermann, 1999; Yang et al, 2014). Again, the direct involvement of hSMVT in pantothenate deficiency is not confirmed.…”

Section: Medical Implicationsmentioning

confidence: 99%

The Sodium/Multivitamin Transporter

Quick¹,

Shi²

2015

Hormones and Transport Systems

View full text Add to dashboard Cite

The Na+/multivitamin transporter (SMVT) is a member of the Solute:Sodium Symporter (SSS) family, that catalyzes the Na+-dependent uptake of the structurally diverse water-soluble vitamins pantothenic acid (vitamin B5) and biotin (vitamin H), α-lipoic acid – a vitamin-like substance with strong anti-oxidant properties – and iodide. The organic substrates of SMVT play central roles in the cellular metabolism and are, therefore, essential for normal human health and development. For example, biotin deficiency leads to growth retardation, dermatological disorders, and neurological disorders. Animal studies have shown that biotin deficiency during pregnancy is directly correlated to embryonic growth retardation, congenital malformation, and death of the embryo. This chapter focuses on the structural and functional features of the human isoform of SMVT (hSMVT) the discovery of which was greatly facilitated by the cloning and expression of hSMVT in tractable expression systems. Special emphasis will be given to mechanistic implications of the transport process of hSMVT that will inform our understanding of the molecular determinants of hSMVT-mediated transport in dynamic context to alleviate the development and optimization of hSMVT as a multipotent platform for drug delivery.

show abstract

Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption

Cited by 21 publications

References 12 publications

High D(+)-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+)-Glucose Diet

High D(+)-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+)-Glucose Diet

Efficacy of a multicomponent nutraceutical on the normalization of liver functional parameters

The Sodium/Multivitamin Transporter

Contact Info

Product

Resources

About