High D(+)-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+)-Glucose Diet

Shibata, Katsumi; Fukuwatari, Tsutomu

doi:10.4137/nmi.s12584

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…Other findings in the study supported this hypothesis. The findings in testes weights in our study are similar to ones in previous studies (Shibata & Fukuwatari, ). A decreased testes weight indicates impaired maturation of germ cells (Uygur et al, ).…”

Section: Discussionsupporting

confidence: 92%

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The effects of high‐fructose corn syrup consumption on testis physiopathology—The ameliorative role of melatonin

Aslankoç

Özmen

2019

Andrologia

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This study investigated the ameliorative role of melatonin (MLT) and the effects of a long‐term intake of high‐fructose corn syrup (HFCS) on the male reproductive system. Thirty‐six male Sprague Dawley rats were randomly divided into 3 groups as follows: Control, HFCS and HFCS + MLT. Testis and epididymal weights were measured. Malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities, total testosterone levels, testicular histopathological damage scores were evaluated, and immunohistochemical analyses were performed on testicular tissue. Epididymal weights were significantly lower in the HFCS + MLT group than those of the control and HFCS groups. MDA was significantly increased, while SOD and CAT activities were reduced in the HFCS group compared with the control group. Administration of melatonin significantly increased SOD and CAT activities in the HFCS + MLT group. Histopathological evaluation revealed slight hyperaemia and oedema in the stromal tissue of rat testes in the HFCS group. Sperm count and Johnsen's testicular biopsy score (JTBS) were significantly decreased in the HFCS group. Immunohistochemical analysis revealed that HSP, iNOS, MDA, OPN and VEGF values were significantly increased in the HFCS group. However, melatonin ameliorated the immunohistochemical scoring. Our results showed that a long‐term intake of HFCS caused testicular damage. Melatonin may be a promising pharmacological agent against testicular toxicity induced by HFCS.

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Section: Discussionsupporting

confidence: 92%

“…Testis is the most sensitive organ, and high‐fructose intake reduces testicular weight. Thus, high‐fructose diets can cause infertility (Shibata & Fukuwatari, ).…”

Section: Introductionmentioning

confidence: 99%

The effects of high‐fructose corn syrup consumption on testis physiopathology—The ameliorative role of melatonin

Aslankoç

Özmen

2019

Andrologia

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“…Possibly altered glucose metabolism due to fructose-feeding might have impaired the testis development at early stages. In support to our observation, a recently published short report during our experiment reported a significant decrease in testis weight in weaning Wistar rats which were fed with 70–80% fructose diets and the authors also reported that glucose supplementation restored the weight of testis [48]. …”

Section: Discussionsupporting

confidence: 90%

Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats

Sakamuri

Pitla

Putcha

et al. 2016

Journal of Nutrition and Metabolism

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Background. Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels. Methods. Rats were divided into control and experimental groups and fed with diets containing 54.5% starch and fructose, respectively, for 4, 12, and 24 weeks. Plasma testosterone and homocysteine levels were measured along with insulin, glucose, and lipids. Body composition, insulin resistance, and hepatic lipids were measured. Results. Increase in hepatic triglyceride content was first observed in metabolic disturbance followed by hypertriglyceridemia and systemic insulin resistance in fructose-fed rats. Hepatic lipids were increased in time-dependent manner by fructose-feeding starting from 4 weeks, but circulatory triglyceride levels were increased after 12 weeks. Fasting insulin and Homeostatis Model Assessment of Insulin Resistance (HOMA-IR) were increased after 12 weeks of fructose-feeding. Decreased visceral adiposity, circulatory testosterone, and homocysteine levels were observed after 4 weeks of fructose-feeding, which were normalized at 12 and 24 weeks. Conclusions. We conclude that transient decrease in circulatory testosterone and homocysteine levels and increased hepatic triglyceride content are the earliest metabolic disturbances that preceded hypertriglyceridemia and insulin resistance in fructose-fed SD rats.

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“…Intake of 70% fructose, but not glucose, negatively affects weight gain in Wistar rats fed the same amount of protein 22 ; however, weight gain in female rats fed a solution of 13% HFCS ad libitum for 8 weeks has also been reported 20 . HFCS may have little effect on females at the 30 th week of life but still favor significant weight gain in males (8% HFCS) 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Weight changes are not explained solely by protein intake; total glucose intake can also affect weight gain. The amount of glucose in the diet of animals consuming fructose should not be less than 23% of total energy intake 22 . In our study, the glucose proportions in the control and HFr diets were 36 and 37%, respectively, thus same glucose intake could explain the equal weight gain of the animals.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

et al. 2015

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OBJECTIVE: To evaluate in Wistar rats the effect of chronic use of high fructose corn syrup on serum lipids, body weight, energy intake regulation, and expression of associated genes. METHODS: For 11 weeks, male rats were fed a standard diet with either water (control) or 15% high fructose corn syrup solution, or fed a high-fat diet. The rats' food intake and body weight were measured weekly. Expression of leptin and fatty acid synthase genes was quantified in their brain and adipose tissue upon sacrifice at age 119 days using real-time polymerase chain reaction. RESULTS: The intake of 15% high fructose corn syrup did not affect the rats' weight, only the rats on the high-fat diet gained significant weight. The rats in both diets had lower levels of leptin expression and high levels of fatty acid synthase in the brain, which were associated with high serum triglycerides. CONCLUSION: Fifteen percent high fructose corn syrup intake and the high-fat diet reduced leptin gene expression in the brain of Wistar rats, with differential effects on weight gain.

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High D(+)-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+)-Glucose Diet

Cited by 6 publications

References 27 publications

The effects of high‐fructose corn syrup consumption on testis physiopathology—The ameliorative role of melatonin

The effects of high‐fructose corn syrup consumption on testis physiopathology—The ameliorative role of melatonin

Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

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