Pantothenic Acid Deficiency and Ubiquinone Levels in Rat Liver Mitochondria

Aiyar, A. S.; Sulebele, Guruprasad; Rege, D. V.; Sreenivasan, A.

doi:10.1038/1841867b0

Cited by 26 publications

(6 citation statements)

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“…The relationship of the succinoxidase content of tissue with the a-tocopherol content (Tappel & Zalkin, 1959;Edwin & Green, 1960) and the dependence of ubiquinone levels on a-tocopherol content (Edwin, Diplock, Bunyan & Green, 1961) would explain the changes observed in the succinoxidase, a-tocopherol and ubiquinone contents of the livers. The parallelism observed between ubiquinone level and succinoxidase activity is in conformity with the reported participation of ubiquinone in electron transport in general and succinoxidase in particular (Aiyar et al 1959;Aiyar & Sreenivasan, 1961;Green & Lester, 1959;Hatefi, Lester, Crane & Widmer, 1959). Table 6 gives the lipid composition of both liver and plasma in terms of total lipids, phospholipids and cholesterol.…”

supporting

confidence: 87%

The effect of variation in the calorie: protein ratio of the diet on nitrogen retention and body composition in the rat

1962

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supporting

confidence: 87%

The effect of variation in the calorie: protein ratio of the diet on nitrogen retention and body composition in the rat

1962

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“…Its content in the tissues and blood of rats receiving thyroid preparations falls considerably [13,202,319]. Similar changes take place in hypothyroidism in man and experimental animals.…”

Section: Metabolismmentioning

confidence: 69%

Physiological Effects of the Thyroid Hormones

et al. 1975

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The thyroid gland has a powerful influence over the activities of the whole body. If the function of the gland is for any reason lost, serious disturbances of chemical and morphological structure arise and are manifested as physical and mental disorders. The diversity of the action of thyroid hormones on physiological functions, on the metabolic rate, and on the activity of various enzyme systems both in the body as a whole and in tissue preparations has been known for a long time. Our knowledge of the role of thyroid hormones is based on experiments in which a particular thyroid hormone has been given to healthy and athyrotic animals and on extensive clinical observations on patients with hyperthyroid and hypothyroid states.The effect of thyroid hormones in vivo is expressed as reactions of whole organs and of individual physiological functions and morphological structures. The internal secretions of the thyroid gland modify growth and metamorphosis, the utilization of oxygen by the body as a whole or by tissue preparations in vitro, various aspects of metabolism, and the activity of particular enzyme systems.The extreme diversity of the effects observed after injection of thyroid hormone may reflect the primary action of this agent on a single link fundamental to the mechanism of biochemical processes in the cell or on a single morphological structure responsible for the proper integration of processes at the cell level. These problems will be examined fully later. Here I shall merely state that when the action of a thyroid hormone is discussed, the term is used not only with respect to the thyroxine and triiodothyronine produced in the thyroid gland, but also to several of their derivatives and analogs. However, we know that all compounds with the biological activity 125 Y. K. Turakulov et al., Thyroid Hormones

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“…At the end of 8 weeks, when the animals fed the iodinated casein showed obvious symptoms of thyrotoxicosis, the animals were exsanguinated. The livers were homogenized and subcellular fractions were prepared as described in the preceding paper (Aiyar & Sreenivasan, 1962).…”

Section: Methodsmentioning

confidence: 99%

“…Vitamin B12 in liver homogenates was determined microbiologically by using Euglena gracilis as test organism (Hoff-Jorgensen, 1954), and succinoxidase was determined manometrically by the method of Schneider & Potter (1943). Ubiquinone in whole liver and in subcellular fractions was estimated as in the preceding paper (Aiyar & Sreenivasan, 1962).…”

Section: Methodsmentioning

confidence: 99%

“…Barker, 1951;Solomon & Dowling, 1960;Kritchevsky, 1960). We have observed that in pantothenic acid-deficient rats there is a decrease in liver ubiquinone (Aiyar, Sulebele, Rege & Sreenivasan, 1959;Aiyar & Sreenivasan, 1961) and also a lowered incorporation of [14C2]acetate and [2-14C]mevalonate into liver ubiquinone (A. S. Aiyar & A. Sreenivasan, unpublished work). These experiments appear to indicate the involvement of coenzyme A in the biosynthesis of ubiquinone.…”

mentioning

confidence: 91%

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