Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress

Ismail, Raed S.; El‐Awady, Mohammed S.; Hassan, Mostafa I.

doi:10.1007/s00210-020-01823-3

Cited by 16 publications

(9 citation statements)

References 51 publications

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“…The results of this study showed that concurrent administration of cisplatin with pantoprazole provided no protection against renal injury or function in young cancer patients [75]. Interestingly, a more recent study showed that pantoprazole can ameliorate CIAKI in mice [62]. Given the contradictory results of OCT2 inhibition on CIAKI in animal-versus-human studies further research needs to be conducted.…”

Section: Organic Cation Transporter 2 (Oct2)mentioning

confidence: 82%

“…The key interventions trialed to date and their effectiveness in targeting CIAKI are also illustrated. Diagram details the cellular processes involved in the cellular uptake [57][58][59][60][61][62][63][64], efflux [65,66], and metabolism of cisplatin into a highly reactive thiol (nephrotoxin) [67] and the treatment targeted to prevent them.…”

Section: Organic Cation Transporter 2 (Oct2)mentioning

confidence: 99%

“…However, there was a reduction trend, and thus a larger-scale trial is required to further assess its amelioration of CIAKI [304]. Pretreatment with pantoprazole has provided an interesting therapy, providing ameliorating effects in preclinical findings [62]; however, in the clinical setting, results showed pantoprazole unprotective preventing cisplatin nephrotoxicity in osteosarcoma patients. This provided further evidence for cancer cell influence on nephrotoxicity and the importance of preclinical tumor-bearing models and publication of the findings of these studies.…”

Section: Ciaki Clinical Trialsmentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

McSweeney

Gadanec

Qaradakhi

et al. 2021

Cancers

201

134

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Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation. Despite research efforts, pharmaceutical interventions, and clinical trials spanning over several decades, a consistent and stable pharmacological treatment option to reduce AKI in patients receiving cisplatin remains unavailable. This has been predominately linked to the incomplete understanding of CIAKI pathophysiology and molecular mechanisms involved. Herein, we detail the extensively known pathophysiology of cisplatin-induced nephrotoxicity that manifests and the variety of pharmacological and genetic alteration studies that target them.

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Section: Organic Cation Transporter 2 (Oct2)mentioning

confidence: 82%

Section: Organic Cation Transporter 2 (Oct2)mentioning

confidence: 99%

Section: Ciaki Clinical Trialsmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

McSweeney

Gadanec

Qaradakhi

et al. 2021

Cancers

201

134

View full text Add to dashboard Cite

show abstract

“…toxicity via reducing apoptosis, inflammation, and inhibiting NF-κB and PARP(Freitas-Lima et al, 2020;Ismail, El-Awady, & Hassan, 2020;H. J.…”

mentioning

confidence: 99%

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Abadi

Mirzaei

Mahabady

et al. 2021

Phytotherapy Research

123

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“…Most of the preclinical and clinical pharmaceuticals under investigation indicate a trend towards a focus on antioxidation, even if several of them do boast potent, secondary, anti-inflammatory qualities. [309,310] This is not necessarily unusual, or unexpected. The use of anti-inflammatory drugs can be complicated-especially within the framework of cancer and chemotherapy.…”

Section: Anti-inflammatory Remediesmentioning

confidence: 87%

Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

Domingo

Latif

Bhavsar

2022

IJMS

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Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), cisplatin-induced peripheral neuropathy (CIPN), and cisplatin-induced ototoxicity (CIO) are the three most common of several CITs recognised thus far. While the anti-cancer activity of cisplatin is well understood, the mechanisms driving its toxicities have only begun to be defined. Most of the literature pertains to damage caused by oxidative stress that occurs downstream of cisplatin treatment, but recent evidence suggests that the instigator of CIT development is inflammation. Cisplatin has been shown to induce pro-inflammatory signalling in CIN, CIPN, and CIO, all of which are associated with persisting markers of inflammation, particularly from the innate immune system. This review covered the hallmarks of inflammation common and distinct between different CITs, the role of innate immune components in development of CITs, as well as current treatments targeting pro-inflammatory signalling pathways to conserve the use of cisplatin in chemotherapy and improve long-term health outcomes of cancer patients.

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Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress

Cited by 16 publications

References 51 publications

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

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