Panton-Valentine Positive Staphylococcus aureus in Community-Acquired and Hospital-Acquired Pediatric Infections

Pereira, Maria Fernanda Bádue; Bando, Sílvia Yumi; Sasagawa, Suzethe Matiko; Silva, Cely Barreto da; Mimica, Marcelo Jenne; Berezin, Eitan Naaman

doi:10.1097/inf.0000000000002425

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…In contrast in France, the majority of strains expressing PVL are MSSA strains. As in our patient, PVL+ SA strains affect mainly young adults without underlying disorder [9] and are more often found in communityacquired infections than in hospital-acquired infections [10]. In community-acquired infections, PVL is an independent marker of severity regardless the resistance of the Staphylococcus aureus strain to methicillin [11].…”

Section: Discussionsupporting

confidence: 59%

Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult – a case report

et al. 2020

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Background Mediastinitis caused by hematogenous spread of an infection is rare. We report the first known case of community-acquired mediastinitis from hematogenous origin in an immunocompetent adult. This rare invasive infection was due to Panton-Valentine Leucocidin-producing (PVL+) methicillin-susceptible Staphylococcus aureus (MSSA). Case presentation A 22-year-old obese man without other medical history was hospitalized for febrile precordial chest pain. He reported a cutaneous back abscess 3 weeks before. CT-scan was consistent with mediastinitis and blood cultures grew for a PVL+ MSSA. Intravenous clindamycin (600 mg t.i.d) and cloxacillin (2 g q.i.d.), secondary changed for fosfomycin (4 g q.i.d.) because of a related toxidermia, was administered. Surgical drainage was performed and confirmed the presence of a mediastinal abscess associated with a fistula between the mediastinum and right pleural space. All local bacteriological samples also grew for PVL+ MSSA. In addition to clindamycin, intravenous fosfomycin was switched to trimethoprim-sulfamethoxazole after 4 weeks for a total of 10 weeks of antibiotics. Conclusions We present the first community-acquired mediastinitis of hematogenous origin with PVL+ MSSA. Clinical evolution was favorable after surgical drainage and 10 weeks of antibiotics. The specific virulence of MSSA PVL+ strains played presumably a key role in this rare invasive clinical presentation.

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Section: Discussionsupporting

confidence: 59%

Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult – a case report

et al. 2020

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“…The rate of methicillin-resistant S. aureus was 37.7%. Skin and soft tissue infections were significantly associated with PVL-positive isolates [ 23 ]. In a prospective study of a cohort of pediatric patients from 13 centers in 7 European countries, 85 children were included; PVL-positive isolates were 17%, and 6% of the isolates were MRSA .…”

Section: Introductionmentioning

confidence: 99%

Retrospective Study on Staphylococcus aureus Resistance Profile and Antibiotic Use in a Pediatric Population

Buonsenso,

Giaimo,

Pata

et al. 2023

Antibiotics

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The growing phenomenon of antibiotic resistance and the presence of limited data concerning the pediatric area prompted us to focus on Staphylococcus aureus infection in this study, its antibiotic resistance profile, and the therapeutic management of affected children. We conducted a retrospective study by collecting clinical data on infants and children with antibiogram-associated S. aureus infection. We enrolled 1210 patients with a mean age of 0.9 years. We analyzed the resistance patterns and found 61.5% resistance to oxacillin, 58.4% resistance to cephalosporins, 41.6% resistance to aminoglycosides, and 38.3% resistance to fluoroquinolones. Importantly, we found no resistance to glycopeptides, a key antibiotic for MRSA infections whose resistance is increasing worldwide. We also found that the main risk factors associated with antibiotic resistance are being aged between 0 and 28 days, the presence of devices, and comorbidities. Antibiotic resistance is a growing concern; knowing the resistance profiles makes it possible to better target the therapy; however, it is important to use antibiotics according to the principles of antibiotic stewardship to limit their spread.

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Panton-Valentine Positive Staphylococcus aureus in Community-Acquired and Hospital-Acquired Pediatric Infections

Cited by 2 publications

References 9 publications

Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult – a case report

Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult – a case report

Retrospective Study on Staphylococcus aureus Resistance Profile and Antibiotic Use in a Pediatric Population

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