Panorama da hepatite B no Brasil e no Estado de Santa Catarina

Chávez, Juliana Helena; Campana, Sabrina Gonçalves; Haas, Patrícia

doi:10.1590/s1020-49892003000700003

Cited by 25 publications

(25 citation statements)

References 5 publications

(2 reference statements)

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“…Este fato se deve, provavelmente, ao estilo de vida, transmissão sexual, transfusional, e a comportamentos que oferecem maior risco, a exemplo do uso de drogas injetáveis e de relações sexuais sem preservativos e com vários parceiros. 11,22 É provável que a maior detecção no sexo feminino com idade entre 15 e 39 anos esteja relacionada a fatores de risco, como a multiplicidade de parceiros sexuais, relações sem preservativos e práticas da comercialização da atividade sexual. 23 Situações de desigualdade nas relações de gênero, em que prevalece a dominação masculina, principalmente nas parceiras fixas, podem estar associadas à maior vulnerabilidade das mulheres ao VHB nessa faixa etária, dada sua dificuldade, na negociação do uso do preservativo com os homens.…”

Section: 18unclassified

“…9,10 O aumento na prevalência da doença ocorre a partir dos 16 anos de idade, sugerindo a transmissão sexual como a principal via de infecção. 11 Os registros de doenças transmissíveis são influenciados por características da doença, que incluem tanto os mecanismos de transmissão como a capacidade dos serviços de saúde em captar os casos. No Brasil, o serviço de hemoterapia, componente da Hemorrede Nacional, foi regulamentado em 2001, 12 quando os casos de hepatite B passaram a ser identificados com maior frequência.…”

Section: Introductionunclassified

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Detecção de infecção pelo vírus da hepatite B nos municípios brasileiros segundo cobertura dos serviços de hemoterapia, no período de 2001 a 2008

Costa¹,

Paula²,

Ignotti³

2012

Epidemiol. Serv. Saúde

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Section: 18unclassified

Section: Introductionunclassified

Detecção de infecção pelo vírus da hepatite B nos municípios brasileiros segundo cobertura dos serviços de hemoterapia, no período de 2001 a 2008

Costa¹,

Paula²,

Ignotti³

2012

Epidemiol. Serv. Saúde

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“…Although most people recover from HBV infection, approximately 10% of infected individuals develop chronic hepatitis, remaining asymptomatic or developing serious liver disease such as cirrhosis or hepatocellular carcinoma (HCC) (Ferreira et al, 2006). One report has pointed out that HBV transmission occurs through blood or bodily fluids such as semen, vaginal discharge, or saliva from infected individuals, with sexual contact being the most common transmission pathway and has indicated that 15% of the population has had contact with HBV and 1% is chronically sick (Chávez et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a histocompatibility antigen related to hepatitis B virus in patients with hepatocellular carcinoma in the western Brazilian Amazon

Chalub

Silva²,

Silva³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Hepatocellular carcinoma is an infection of variable incidence that can be caused by hepatitis B virus (HBV), which is endemic in the Amazon region. The diagnosis of HBV can be performed through the use of serum markers such as the hepatitis B surface antigen. The chronic HBV can cause mutagenesis and carcinogenesis, being the susceptibility of infection due to allele human leukocyte antigen (HLA). Thus, we evaluated the clinical, molecular and laboratory profile (histocompatibility complex) of HBV in 22 patients with hepatocellular Evaluation of HLA in patients with hepatocellular carcinoma carcinoma in Amazonia, including 18 males and 4 females, using a blood sample for generic HLA class II. The results showed increased frequency of disease evolution in adults between 25 and 64 years old, who comprised 19 of the 22 patients studied. Most patients (16/22) presented high levels of alpha-fetoprotein and transaminases (14/22). The most common HLA alleles were DRB1*04 (8/44), DRB1*08 (9/44), DRB*03 (16/44), and DQB1*04 (9/44). When we compared specific phenotype frequencies of HLA-DRB1* between patients and controls, we found that patients had a significantly higher frequency of allele DRB1*08 and a significantly lower frequency of DRB1*07 and DRB1*12 compared to previous studies on Asian and Amazonian populations suggesting ethnic differences. We suggest that alleles HLA-DRB*08, HLA-DRB*03 and HLA-DQB1*04 may be risk factors for hepatocellular carcinoma in Amazon.

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“…Costa et al (2012) observed that the age group most affected with hepatitis B varied by gender in Brazil, with greatest incidence in males aged 40-69 years and in women aged 15-39 years. These age groups are more likely to get hepatitis B because these age groups often have a lifestyle that has a high risk of transmission of HBV, particularly with respect to sexual activity and the number of partners (Chávez et al 2003). Furthermore, the detection of hepatitis B between the ages of 1 and 14 years in Brazil has decreased possibly due to the inclusion of the vaccine against HBV in the calendar of the National Immunization Program in 1997 (Brasil 2012).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of hepatitis B virus in the cities of the northern region of Espírito Santo, Brazil

Fontes

Ardisson

Souza

et al. 2016

An. Acad. Bras. Ciênc.

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The World Health Organization (WHO) estimates that approximately 2 billion people worldwide have already had contact with hepatitis B virus (HBV) and 373 million have become chronic carriers. Hepatitis B is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma, leading to a large number of deaths annually. Both viral factors and the host immune response have been implicated in the pathogenesis and clinical result of HBV infection. Many Brazilian cities, including the cities of the northern region of the state of Espírito Santo are located in regions with little health infrastructure. Our study performed an epidemiological analysis of cases of Hepatitis B in São Mateus, using methodology of Geographic Information System (GIS), aiming to raise the number of disease cases, establishing preventive measures to control the disease, improving the quality of life of people affected by this pathology. The city of São Mateus had the largest number of reported cases of hepatitis B northern region of Espírito Santo. The age group with the highest number of hepatitis B notifications was 20-49 years, mostly females. The major forms of contact with HBV in these cities were dental treatment, use of injectable medications, surgical procedures and multiple sexual partners.

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Panorama da hepatite B no Brasil e no Estado de Santa Catarina

Cited by 25 publications

References 5 publications

Detecção de infecção pelo vírus da hepatite B nos municípios brasileiros segundo cobertura dos serviços de hemoterapia, no período de 2001 a 2008

Detecção de infecção pelo vírus da hepatite B nos municípios brasileiros segundo cobertura dos serviços de hemoterapia, no período de 2001 a 2008

Evaluation of a histocompatibility antigen related to hepatitis B virus in patients with hepatocellular carcinoma in the western Brazilian Amazon

Epidemiology of hepatitis B virus in the cities of the northern region of Espírito Santo, Brazil

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