Paniculitis eosinofílica secundaria a infección por COVID-19

Seo

et al. 2020

Preprint

Despite the worldwide effect of the Coronavirus disease 2019 (COVID-19) pandemic, the underlying mechanisms of fatal viral pneumonia remain elusive. Here, we conducted kinetic profiling of respiratory leukocytes and associated inflammatory mediators to show that severe COVID-19 is associated with delayed but enhanced eosinophilic inflammation when compared to mild cases. In addition, we confirmed increased Th2-biased adaptive immune responses, accompanying overt complement activation, in the severe group. Moreover, enhanced antibody responses and complement activation was associated with disease pathogenesis as evidenced by formation of immune complexes and membrane attack complexes in airways and vasculature of lung biopsies from a fatal case, as well as by enhanced hallmark gene set signatures of FcgR signaling and complement activation in myeloid cells of respiratory specimens from severe COVID-19 patients. We also observed expression of viral antigen in lung epithelial and endothelial cells without producing viruses during late stage of COVID-19, indicating abortive viral infection which may further fuel antibody responses and aggravate immune-complex-mediated inflammation. These results suggest that SARS-CoV-2 infection may drive scripted specific innate immune responses, including eosinophilic inflammation, and subsequent pulmonary pathogenesis via enhanced Th2-biased immune responses, which might be crucial drivers of severe pneumonia in COVID-19 patients.

Section: Resultsmentioning

confidence: 75%

Enhanced eosinophilic inflammation associated with antibody and complement-mediated pneumonic insults in severe COVID-19

Seo

et al. 2020

Preprint

“…Excessive cytokine (IL-4, IL-5) production and exaggerated neutrophilic host immune response to COVID-19 infection lead to neutrophilic infiltration in subcutaneous fat. 2,3 Patient showed good symptomatic response to Wysolone 40 mg. Creatine phosphokinase level was raised (3736 IU/L). Antinuclear and anti-smooth muscle antibodies were negative.…”

Section: Figurementioning

confidence: 96%

mentioning

confidence: 94%

“…It may be idiopathic or associated with hematological malignancies, drugs, systemic disorders, or viral infections, such as SARS-CoV-2 in our case. Excessive cytokine (IL-4, IL-5) production and exaggerated neutrophilic host immune response to COVID-19 infection lead to neutrophilic infiltration in subcutaneous fat 2,3 . Patient showed good symptomatic response to Wysolone 40 mg.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Post–COVID-19 Unusual Inflammatory Syndromes Detected on 18F-FDG PET/CT Scan

Pereira

Shivdasani²,

Roy³

et al. 2022

Clin Nucl Med

SARS-CoV-2 is primarily known to cause respiratory symptoms. However, in this global COVID-19 pandemic, we have come across many extrapulmonary manifestations during and in the immediate post-COVID phase such as gastrointestinal symptoms, kidney and liver injury, myocardial dysfunction and acute coronary syndromes, and neurological, thromboembolic, dermatological, and musculoskeletal disorders. We present 2 such unusual cases of post-COVID complications—diffuse panniculitis and inflammatory myositis, as well as their clinical and FDG PET/CT imaging features.

Journal of Medical Virology

“… 36 Several other lesions have been reported for COVID‐19, some of which cannot be categorized into one of the mentioned groups. Examples include pityriasis rosea‐like rash, 37 Grover's disease‐like eruptions, 23 , 38 acro‐ischemia, 39 malar erythema, and facial edema, 40 palmar erythema, 41 symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE)‐like eruptions, 42 hand‐foot‐mouth‐like diseases, 24 “COVID toes” or pernio‐like eruptions, 43 Dengue‐like rashes, 33 diffuse melanoderma, 44 gangrene, 45 paronychia, 46 sacral and buttocks ulcerations, 47 mottling, 48 lichenoid eruptions, 49 drug reaction with eosinophilia and systemic symptom (DRESS), 50 acute generalized exanthematous pustulosis (AGEP), 51 Raynaud's phenomenon, 52 eruptive cherry angioma, 1 violaceous macules with “porcelain‐like” appearance, 53 IgA vasculitis, 54 leukocytoclastic vasculitis, 55 retiform purpura, eosinophilic panniculitis, 56 and periorbital dyschromia. 57 …”

Section: Morphologymentioning

confidence: 99%

Dermatological manifestations associated with COVID‐19: A comprehensive review of the current knowledge

Afshar

Babazadeh

Hasanpour

et al. 2021

Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has become a significant health problem globally. The virus has spread widely and become a global pandemic. The pathophysiology for SARS‐CoV‐2 has not been explained clearly. It has been associated with several multiorgan symptoms, among which its dermatological manifestations are of great interest. Primarily, there has been no report of skin features among COVID‐19 patients. Nevertheless, recently there have been several reports regarding COVID‐19 patients who presented with cutaneous manifestations. In the current review, we focus on the various cutaneous manifestations of COVID‐19 infection.