Pancytopenia in Multiple Myeloma- An Enigma: Our Experience from Tertiary Care Hospital

Basavaiah, Sridevi Hanaganahalli; Rai, Sharada; Suresh, Pooja K; Somesh, M. S.; Minal, Jessica

doi:10.7860/jcdr/2015/12788.6718

Cited by 9 publications

(8 citation statements)

References 10 publications

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“…Our incidence of 0,5% is lower than expected from a retrospective study conducted by Subramanian et al where 9% of the NDMM patients presented themselves with pancytopenia [3]. On the other hand, Sridevi HB et al validates the rarity of this presentation in their retrospective cohort study by calling pancytopenia in NDMM likewise an enigma [4].…”

Section: Discussioncontrasting

confidence: 50%

Severe pancytopenia as presenting feature in newly diagnosed multiple myeloma (NDMM): a rare presentation.

Vriendt¹

2018

Preprint

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Section: Discussioncontrasting

confidence: 50%

Severe pancytopenia as presenting feature in newly diagnosed multiple myeloma (NDMM): a rare presentation.

Vriendt¹

2018

Preprint

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“…Their study emphasized the need for a differential diagnosis of myeloma among elderly patients with pancytopenia, for timely and accurate management of these cases. 15 Leishmaniasis was reported on BMA alone. BMB provided no additional information regarding diagnosis, similar to the study carried out by Goyal et al 6 A report by Kumar PV et al 16 on studying 249 cases of leishmaniasis on bone marrow biopsy observed that biopsy aided in providing an accurate view on the prognosis among patients with leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of bone marrow aspirate with trephine biopsy in pancytopenia disorders

Mk¹,

Kavya

2021

JDPO

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Pancytopenia is commonly reported in clinical hematology practice. Due to its varied marrow pathology and underlying ailments, diagnosis is often misleading and delayed. Bone marrow examination would provide a comprehensive diagnosis of both blood and bone marrow, since aspirate investigates the cytological morphology and biopsy evaluates the cellularity, architecture, and compact marrows.To compare bone marrow aspiration and trephine biopsy results in the diagnosis of pancytopenia, and to determine the sensitivity and specificity of aspirate examination in pancytopenia diagnosis.This prospective study was conducted at a tertiary care hospital from July 2014 to June 2016. A total of 320 samples were received at the department of pathology for bone marrow examination (aspirate and biopsy). Romanowsky (Leishman) stain was used to investigate aspirate samples. All biopsy samples were processed into 3-5 μ blocks and stained using hematoxylin and eosin after decalcification with 5.5% EDTA. Data analysis was performed using SPSS19.Pancytopenia constituted 56 (18.7%) cases with the mean age of 41.79 years. Of the total pancytopenia cases, hematological disorders constituted 50 (89.3%) cases and 6 (10.7%) were non-hematological cases. Aspirate and biopsy diagnosis positively correlated in 76.79% of cases. A 100% sensitivity and specificity of aspirate diagnosis was observed in, acute myeloid leukemia, hypersplenism, myelodysplastic syndrome, megaloblastic anemia, hematological malignancy in remission and negative for lymphoma infiltrate. Aspirate had no role in diagnosis of uremic osteodystrophy and myelofibrosis, whereas leishmaniasis was diagnosed on aspirate alone.Pancytopenia includes multiple underlying ailments which requires a differential diagnosis approach. Combining both aspirate and biopsy for diagnosis would benefit the patient in prognosis as they are complementary to each other.

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“…Other known causes include myeloma treatment-related side effects, the induction of apoptosis due to the engagement of Fas-by-Fas ligand, which is mediated by caspase activation, and cytokine-mediated BM failure through interleukin (IL)-6, IL-11, and granulocyte-macrophage colony-stimulating factor (GM-CSF). Lastly, renal failure, a complication seen in some myeloma cases, has the potential to cause impaired erythropoietin production [ 8 ].…”

Section: Pathogenesismentioning

confidence: 99%

Multiple Myeloma: A Review of the Literature and a Case Report Highlighting the Immunocompromised State of Myeloma Patients

Nightingale,

Decker,

Ryan

et al. 2024

World J Oncol

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Multiple myeloma (MM), a malignancy involving plasma cells, disproportionately affects older adults with an average age of diagnosis of about 70 years. Oftentimes, the therapies used in the treatment of MM are associated with a risk for immunotoxicity, lowering the ability of the immune system to fight off opportunistic infections. This is an important relationship for clinicians to realize as the incidence of opportunistic infections in myeloma patients is increasing. As an example, we present a case of a patient with MM who subsequently developed a cryptococcal infection. Our paper will highlight the key details of the case as well as shed light on the importance of understanding the immunodeficiencies in this patient population. We highlight important aspects of the current literature related to MM and relate them to the associated case.

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Pancytopenia in Multiple Myeloma- An Enigma: Our Experience from Tertiary Care Hospital

Cited by 9 publications

References 10 publications

Severe pancytopenia as presenting feature in newly diagnosed multiple myeloma (NDMM): a rare presentation.

Severe pancytopenia as presenting feature in newly diagnosed multiple myeloma (NDMM): a rare presentation.

A comparative study of bone marrow aspirate with trephine biopsy in pancytopenia disorders

Multiple Myeloma: A Review of the Literature and a Case Report Highlighting the Immunocompromised State of Myeloma Patients

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