Pancytopenia- an etiological profile

Raphael, Vandana; Khonglah, Yookarin; Dey, Biswajit; Gogoi, Pranjal; Bhuyan, Ashim

doi:10.5505/tjh.2012.98360

Cited by 15 publications

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References 4 publications

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“…et al found 8.7% cases of dimorphic anemia as second most common cause and Prabhala et al Found 14.53% cases of dimorphic anemia as third most common cause of pancytopenia in their study [8,14]…”

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confidence: 92%

A study of clinico-hematological profile of pancytopenic patients in Central India

2017

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Background: To segregate the causes of pancytopenia which are easily treatable, from those requiring sophisticated investigations & vigorous treatment, based on clinico-hematological profile of the patients and affordable diagnostic mathods. Materials and Methods: 180 Pancytopenic patients were evaluated clinically along with hematological parameters, peripheral smears and bone marrow aspiration in the Department of Pathology, GMC, Bhopal for 3 years. Result: Age range was 5 months-70 years (mean-26.6 years), with Male preponderance (M: F: 1.76:1). Commonest symptoms were weakness (97.8%), breathlessness (75%) and signs were pallor (98.3%) and splenomegaly (25.5%). Patients who presented with per rectal bleeding, in 46.2% diagnosis was dimorphic anemia thus per rectal bleeding was cause of associated iron deficiency. Commonest peripheral smear finding was microcytic hypochromic picture (27.22 %) & bone marrow was hypercellular (70.00%). Bone marrow aspiration revealed commonest cause was megaloblastic anemia (25%) followed by dimorphic anemia (17.2%) and infections (17.2%). In our study MCV was <100 fl in 12/45 (26.66%) cases of megaloblastic anemia so even if a patient presents with MCV < 100 fl megaloblastic anemia should not be ruled out only on this basis. Sensitivity of peripheral smear for dimorphic anemia was very low 35.48% and specificity was 82.55%, so bone marrow examination should be investigation of choice for inconclusive peripheral smears. Conclusion: Common causes of pancytopenia were easily treatable and reversible & can be detected by early and affordable diagnostic methods therefore should be considered at higher order in differential diagnosis of pancytopenia.

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confidence: 92%

A study of clinico-hematological profile of pancytopenic patients in Central India

2017

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“…Raphael et al found 8.7% cases of dimorphic anaemia as the second most common cause and Prabhala et al found 14.53% cases of dimorphic anaemia as the third most common cause of pancytopenia. 27,28 A dimorphic blood film is seen when iron deficiency anaemia responds to iron therapy after the transfusion of normal blood to a patient with hypochromic anaemia, sideroblastic anaemia, an unmasking of an iron deficiency following treatment of megaloblastic anaemia, delayed transfusion reactions and dual deficiency of iron and either vitamin B12 or folic acid.…”

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confidence: 99%

Clinico-hematological evaluation in cases of pancytopenia at tertiary care centre: largest cross-sectional study

2021

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Background: Pancytopenia is characterised by a reduction in all the three cellular elements of blood (erythrocytes, leukocytes and platelets) below the normal reference range leading to anaemia, leucopenia and thrombocytopenia. It is a feature of many serious conditions. The present study was conducted to assess aetiology, clinical profile and bone marrow morphology of conditions presenting with pancytopenia.Methods: A two years cross-sectional study from July 2017 to June 2019 was conducted in the Department of Pathology. Total of 300 pancytopenia patient were studied and their clinical features, peripheral smear finding and bone marrow morphology were studied by using marrow aspiration and biopsy.Results: Among 300 cases studied, maximum patients were in the age group 11-20 years (19.66%) with male (50.66%) predominance. Most of the patients presented with weakness (91.66%) and fever (56.66%) as chief complains. The commonest physical finding was pallor (94%) followed by splenomegaly (27.33%). Macrocytic anaemia (43.66%) was commonest peripheral finding. The commonest cause of pancytopenia was megaloblastic anaemia (32.66%) followed by dimorphic anaemia (21%), aplastic anaemia (16%) and acute leukaemia (13.33%).Conclusions: The present study concludes that detailed clinical history, primary haematological investigations along with bone marrow examinations is essential to determine the cause of pancytopenia.

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“…Detailed clinical history and meticulous physical examination along with baseline hematological investigations provide invaluable information in the evaluation of pancytopenic patients, helping in systematic planning of further investigations to diagnose and ascertain the cause, avoiding unnecessary tests which not only add to the expense of treatment but sometimes also may result in delayed diagnoses and treatment [4]. As a large proportion of causes for pancytopenia are treatable and reversible, accurate diagnoses and timely intervention maybe lifesaving and will certainly have impact on the morbidity and mortality in these vulnerable patients.…”

Section: Introductionmentioning

confidence: 99%

Pancytopenia: An Update

Das¹

2020

Journal of Experimental Pathology

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Pancytopenia- an etiological profile

Cited by 15 publications

References 4 publications

A study of clinico-hematological profile of pancytopenic patients in Central India

A study of clinico-hematological profile of pancytopenic patients in Central India

Clinico-hematological evaluation in cases of pancytopenia at tertiary care centre: largest cross-sectional study

Pancytopenia: An Update

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