Pancreatitis is frequent among patients with side-branch intraductal papillary mucinous neoplasia diagnosed by EUS

Ringold, Daniel A.; Shroff, Puneet; Sikka, Sanjay; Ylagan, Lourdes; Jonnalagadda, Sreenivasa S.; Early, Dayna S.; Edmundowicz, Steven A.; Azar, Riad R.

doi:10.1016/j.gie.2008.11.039

Cited by 35 publications

(24 citation statements)

References 25 publications

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“…Acute pancreatitis often develops in patients with IPMNs, regardless of its morphological, main duct and branch duct type [1,2,3]. IPMNs have a broad spectrum of dysplasia ranging from adenoma to borderline neoplasm, carcinoma in situ, and further to invasive carcinoma, progressing sequentially in a stepwise fashion [4].…”

Section: Introductionmentioning

confidence: 99%

A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype

et al. 2011

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Section: Introductionmentioning

confidence: 99%

A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype

et al. 2011

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“…The rate of recurrence of AP as a complication of IPMN and the number of AP episodes per patient have been reported to be 47-73% [18][19][20]33,34] and 2.5-3.4 times [18,19], respectively. However, in the present study, the corresponding figures were 25% (4/16) and 1.4 ± 0.9 times, respectively, both being lower than those reported previously [18][19][20]33,34]. These figures may reflect the fact that IPMN patients with AP in this study underwent surgery at a comparatively earlier stage than those in the other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Acute pancreatitis (AP) and obstructive chronic pancreatitis of varying severity are known to occur as complications of IPMN as a result of tumor mucus production and obstruction of the pancreatic duct due to intraductal proliferation [1,[18][19][20][21][22]. Although some features of IPMN complicated by AP have been reported [18][19][20]23], many aspects including the issue of whether or not AP is a predictor of malignancy remain controversial.…”

Section: Introductionmentioning

confidence: 99%

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Acute Pancreatitis is a Predictive Factor for Malignancy in Mixed or Main Duct Intraductal Papillary Mucinous Neoplasms

Kimura

Tezuka²

2015

Pancreat Disord Ther

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Objectives: It is still unclear whether acute pancreatitis (AP) is a predictor of malignancy. Using patients enrolled from a single institution, the objective of this study was to determine whether AP as a complication of intraductal papillary mucinous neoplasm (IPMN) predicts malignancy, and to clarify the clinicopathological characteristics of IPMN with AP. Methods:The clinicopathological features of 87 patients who underwent surgical resection for IPMN between October 1998 and May 2010 were investigated. In this study, malignancy was defined as high-grade dysplasia (noninvasive carcinoma) and invasive carcinoma. Macroscopic classification was based on the 2012 international consensus guidelines and IPMN with a main pancreatic duct size of >5 mm was classified as either mixed or main duct IPMN. Conclusions: AP itself may not be a predictive factor for malignancy in IPMN, but may be such a predictor in mixed or main duct IPMN. AP is also an important clinical sign that must not be overlooked, as it may indicate the presence of malignant lesions at an earlier stage.

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“…Andererseits ist auch bei Vorliegen einer leichten Pankreatitis die Differenzierung zwischen einer zystischen Neoplasie als Pankreatitisursache und einer Pseudozyste als Pankreatitisfolge im Einzelfall anspruchsvoll (fig. 1) [3]. Differenzialdiagnostisch kommen Retentionszysten, seröse Zystadenome, muzinöse Neoplasien und intraduktale papilläre muzinöse Neoplasien (IPMN) infrage [4].…”

Section: Differenzialdiagnoseunclassified

Endoskopische Drainage von Pankreaspseudozysten

Denzer¹,

Rösch²

2012

Visc Med

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Hintergrund: Die Pankreaspseudozyste ist eine häufige Komplikation der akuten oder chronischen Pankreatitis. Bei symptomatischer Zyste mit Vorliegen von abdominellen Schmerzen, einer Magenausgangsstenose, Gewichtsverlust, Ikterus, Infektion oder Größenzunahme stellt die endoskopische Drainage (transpapillär und/ oder transmural) eine effektive Erstlinientherapie dar. Methode: Die Übersicht basiert auf einer strukturierten Analyse der aktuellen, in Pubmed gelisteten Studien. Ergebnisse: Die Langzeitregressionsraten liegen bei 71–90%; die Komplikationsrate beträgt 3–35% mit einer geringen Mortalität von 0–1%. Die wesentlichen Komplikationen der endoskopischen Pseudozystendrainage sind Blutungen in bis zu 9%, Infektionen in bis zu 8%, retroperitoneale Perforation in bis zu 5% und Zystenrekurrenz in bis zu 14% der Fälle. Differenziert zu betrachten sind die infizierte Nekrose und der Pankreasabszess (walled-off necrosis) nach akuter Pankreatitis. In diesen Fällen ist die endoskopische Therapie technisch komplexer und im Vergleich zur unkomplizierten Pankreaspseudozyste mit höherer Morbidität und geringerem Langzeitansprechen verbunden. Dennoch stellt die endoskopische Drainage bei technischer Machbarkeit für beide Entitäten die Methode der ersten Wahl dar. Dies basiert insbesondere auf der nach aktuellen Daten geringeren Morbidität der Methode im Vergleich zu chirurgischen Drainageverfahren. Schlussfolgerung: Der vorliegende Review gibt einen Überblick über Therapieindikation und Differenzialdiagnose von Pankreaspseudozysten, erläutert die Drainagetechniken und stellt die Daten zu Effektivität und Komplikationen der endoskopischen Zystendrainage umfassend dar.

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Pancreatitis is frequent among patients with side-branch intraductal papillary mucinous neoplasia diagnosed by EUS

Cited by 35 publications

References 25 publications

A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype

A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype

Acute Pancreatitis is a Predictive Factor for Malignancy in Mixed or Main Duct Intraductal Papillary Mucinous Neoplasms

Endoskopische Drainage von Pankreaspseudozysten

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