A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype

Tsutsumi, Kosuke; Ohtsuka, Takao; Oda, Yasunori; Sadakari, Yoshihiko; Mori, Yasuhisa; Aishima, Shinichi; Takahata, Shunichi; Nakamura, Masafumi; Mizumoto, Kazuhiro; Tanaka, Masao

doi:10.1159/000320696

Cited by 30 publications

(28 citation statements)

References 18 publications

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“…It is still controversial whether AP predicts malignancy in IPMN [18,19]. In the present study, there was no significant difference in the frequency of malignancy between IPMN patients with and without AP [63% (10/16) vs. 38% (27/71); p=0.096], which appears to support the results of some previous studies [19,[28][29][30][31][32][33][34][35].…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, there was no significant difference in the frequency of malignancy between IPMN patients with and without AP [63% (10/16) vs. 38% (27/71); p=0.096], which appears to support the results of some previous studies [19,[28][29][30][31][32][33][34][35]. However, other studies have found significant differences in the frequency of malignancy between IPMN patients with and without AP [18,29]. The reason for this difference in findings among studies is still unclear.…”

Section: Discussionsupporting

confidence: 89%

“…The variation in the frequency of AP among the previous studies may be attributable to factors such as differences in race and in the definition of AP. In the present study, AP was defined according to the diagnostic criteria formulated by the MHLW Research Committee for Intractable Pancreatic Disease [24], and most cases of AP that occurred as a complication of IPMN were mild, a finding consistent with other reports [18,19].…”

Section: Discussionsupporting

confidence: 78%

“…Acute pancreatitis (AP) and obstructive chronic pancreatitis of varying severity are known to occur as complications of IPMN as a result of tumor mucus production and obstruction of the pancreatic duct due to intraductal proliferation [1,[18][19][20][21][22]. Although some features of IPMN complicated by AP have been reported [18][19][20]23], many aspects including the issue of whether or not AP is a predictor of malignancy remain controversial.…”

Section: Introductionmentioning

confidence: 99%

“…Although some features of IPMN complicated by AP have been reported [18][19][20]23], many aspects including the issue of whether or not AP is a predictor of malignancy remain controversial.…”

Section: Introductionmentioning

confidence: 99%

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Acute Pancreatitis is a Predictive Factor for Malignancy in Mixed or Main Duct Intraductal Papillary Mucinous Neoplasms

Kimura

Tezuka²

2015

Pancreat Disord Ther

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Objectives: It is still unclear whether acute pancreatitis (AP) is a predictor of malignancy. Using patients enrolled from a single institution, the objective of this study was to determine whether AP as a complication of intraductal papillary mucinous neoplasm (IPMN) predicts malignancy, and to clarify the clinicopathological characteristics of IPMN with AP. Methods:The clinicopathological features of 87 patients who underwent surgical resection for IPMN between October 1998 and May 2010 were investigated. In this study, malignancy was defined as high-grade dysplasia (noninvasive carcinoma) and invasive carcinoma. Macroscopic classification was based on the 2012 international consensus guidelines and IPMN with a main pancreatic duct size of >5 mm was classified as either mixed or main duct IPMN. Conclusions: AP itself may not be a predictive factor for malignancy in IPMN, but may be such a predictor in mixed or main duct IPMN. AP is also an important clinical sign that must not be overlooked, as it may indicate the presence of malignant lesions at an earlier stage.

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