Pancreatitis associated with pancreatic carcinoma

Balthazar, Emil J.

doi:10.1159/000086868

Cited by 72 publications

(14 citation statements)

References 65 publications

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“…Some of these efforts have resulted in downstaging of locally advanced pancreatic cancer in a limited number of patients [1–6]. However, therapy-induced regional changes, including pancreatitis, may affect the pancreas and surrounding structures [7, 8], We hypothesize that local changes induced by neoadjuvant therapy decrease the accuracy of CT interpretations of resectability, even when state-of-the-art multiphasic MDCT is used.…”

mentioning

confidence: 99%

Resectability of Pancreatic Adenocarcinoma in Patients with Locally Advanced Disease Downstaged by Preoperative Therapy: A Challenge for MDCT

Morgan

Waggoner²,

Canon³

et al. 2010

American Journal of Roentgenology

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confidence: 99%

Resectability of Pancreatic Adenocarcinoma in Patients with Locally Advanced Disease Downstaged by Preoperative Therapy: A Challenge for MDCT

Morgan

Waggoner²,

Canon³

et al. 2010

American Journal of Roentgenology

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“…Second-line imaging investigations (EUS, MRCP, CT) are required from the very first attack of AP in patients whose condition is etiologically undefined after basic tests. The significant diagnostic role of spiral CT and EUS in excluding neoplastic causes has been demonstrated 25. Moreover, where the gallbladder is in situ, the search for biliary sludge and microlithiasis is strongly suggested, since data reported in the literature confirm the role they play in the genesis of AP 26,27.…”

Section: Discussionmentioning

confidence: 99%

Defining a Therapeutic Program for Recurrent Acute Pancreatitis Patients with Unknown Etiology

Neri

Lapolla

Lascia

et al. 2014

Clin Med Insights Gastroenterol

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AIMTo define a therapeutic program for mild-moderate acute pancreatitis (AP), often recurrent, which at the end of the diagnostic process remains of undefined etiology.MATERIAL AND METHODSIn the period 2011–2012, we observed 64 cases of AP: 52 mild-moderate, 12 severe; biliary 39, biliary in alcoholic chronic pancreatitis 5, unexplained recurrent 20. The clinical and instrumental evaluation of the 20 cases of unexplained AP showed 6 patients with biliary sludge, 4 microlithiasis, 4 sphincter of Oddi dysfunction, and 6 cases that remained undefined.RESULTSAmong 20 patients with recurrent, unexplained AP at initial etiological assessment, we performed 10 video laparo cholecystectomies (VLCs), 2 open cholecystectomies and 4 endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomies (ERCP/ES) in patients who had undergone previous cholecystectomy; 4 patients refused surgery. Among these 20 patients, 6 had AP that remained unexplained after second-level imaging investigations. For these patients, 4 VLCs and 2 ERCP/ES were performed. Follow-up after six months was negative for further recurrence.CONCLUSIONThe recurrence of unexplained acute pancreatitis could be treated with empirical cholecystectomy and/or ERCP/ES in cases of previous cholecystectomy.

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“…While a majority of IPMN patients are symptomatic, others have been identified from radiologic studies performed for unrelated problems. Although AP-like abdominal pain is present in from 13 to 43% of IPMN patients [7][8][9][10][11][12][13], only 13 to 23% of AP cases involve IPMN [10][11][12]. In a recent report of 185 IPMN patients treated surgically, the duration between the first attack and the time of surgical resection ranged from 1 to 204 months [9].…”

Section: Discussionmentioning

confidence: 99%

Repeating regional acute pancreatitis in the head of the pancreas caused by intraductal papillary mucinous neoplasms in the tail: report of a case

et al. 2012

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Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a distinct entity characterized by papillary proliferations of mucin-producing epithelial cells with excessive mucin production and cystic dilatation of the pancreatic ducts. The clinical presentation often involves recurrent episodes of pancreatitis associated with the temporal obstruction of the main pancreatic duct caused by the hypersecretion of mucin. We herein describe a case in which the patient repeatedly experienced the occurrence of idiopathic acute pancreatitis in the head of the pancreas over a 9-year period, and who was ultimately was cured by distal pancreatectomy for IPMNs in the pancreatic tail. This case illustrates the potential pitfalls in the diagnosis of IPMNs owing to a discrepancy between the site of pancreatitis and that of the IPMN. The possible mechanisms linking acute pancreatitis with the formation of IPMNs are also reviewed.

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Pancreatitis associated with pancreatic carcinoma

Cited by 72 publications

References 65 publications

Resectability of Pancreatic Adenocarcinoma in Patients with Locally Advanced Disease Downstaged by Preoperative Therapy: A Challenge for MDCT

Resectability of Pancreatic Adenocarcinoma in Patients with Locally Advanced Disease Downstaged by Preoperative Therapy: A Challenge for MDCT

Defining a Therapeutic Program for Recurrent Acute Pancreatitis Patients with Unknown Etiology

Repeating regional acute pancreatitis in the head of the pancreas caused by intraductal papillary mucinous neoplasms in the tail: report of a case

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