Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma

Huddy, Jeremy R; Sodergren, Mikael H.; Deguara, Jean; Thway, Khin; Jones, Robin L.; Mudan, Satvinder

doi:10.21873/anticanres.12693

Cited by 4 publications

(4 citation statements)

References 27 publications

(37 reference statements)

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“…The cat with the pleomorphic sarcoma in our study had increased SAA values of an unknown cause and the pathogenesis of the tumor remained unclear. In human medicine, recurrence of metastatic sarcomas in the pancreas is common and a median overall survival time of 21 months [17] as well as moderate complication rates [18] have been described. The cats in our study were euthanized during surgery because of the poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…There is one case report of a feline primary pancreatic carcinosarcoma with metastases in uterus, omentum, and diaphragm [16]. Mesenchymal pancreatic tumors in humans are reported to have a poor prognosis with a median overall survival time of 21 months [17,18]. Visceral hemangiosarcomas are a common neoplasm in dogs, especially German Shepherds, but are uncommon in cats [19].…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats

Törner

Staudacher

Steiger

et al. 2020

Veterinary Sciences

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Tumors of mesenchymal origin are rarely reported in the pancreas. Therefore, this study characterized 17 feline non-epithelial pancreatic tumors, including clinical data, histopathology, and immunohistochemistry. Seventeen feline pancreatic tissue samples were investigated histopathologically and immunohistochemically. Selected pancreatic and inflammatory serum parameters, e.g., feline pancreatic lipase immunoreactivity (fPLI), 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase and serum amyloid A (SAA), were recorded, when available. The neoplasms were characterized as round (n = 13) or spindle (n = 4) cell tumors. Round cell tumors included 12 lymphomas and one mast cell tumor in ectopic splenic tissue within the pancreas. Lymphomas were of T-cell (n = 9) or B-cell (n = 3) origin. These cats showed leukocytosis (3/3) and increased fPLI (5/5), DGGR lipase (3/5) and SAA (4/5) values. Spindle cell tumors included two hemangiosarcomas, one pleomorphic sarcoma and one fibrosarcoma. The cat with pleomorphic sarcoma showed increased SAA value. Overall survival time was two weeks to seven months. These are the first descriptions of a pancreatic pleomorphic sarcoma and a mast cell tumor in accessory spleens within feline pancreas. Although rare, pancreatic tumors should be considered in cats presenting with clinical signs and clinical pathology changes of pancreatitis. Only histopathology can certainly distinguish solitary pancreatitis from a neoplasm with inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats

Törner

Staudacher

Steiger

et al. 2020

Veterinary Sciences

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“…In a tertiary-referral hospital for soft-tissue sarcoma with 6744 new cases of soft-tissue sarcoma, 7 underwent duodenopancreatectomy for sarcoma metastases to the pancreatic head. The median survival was 21 months (range: 4 days to 86 months) [117].…”

Section: Sarcomamentioning

confidence: 99%

Comments on and Illustrations of the EFSUMB CEUS Guidelines: Transabdominal and Endoscopic Ultrasound Features of Intrapancreatic Metastases and the Role of Multiparametric Imaging and EUS-Guided Sampling in Rare Pancreatic Tumors

Möller

Jenssen

Braden

et al. 2023

Cancers

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A definite pathologic diagnosis of intrapancreatic metastasis is crucial for the management decision, i.e., curative or palliative surgery versus chemotherapy or conservative/palliative therapy. This review focuses on the appearance of intrapancreatic metastases on native and contrast-enhanced transabdominal ultrasound and endoscopic ultrasound. Differences and similarities in relation to the primary tumor, and the differential diagnosis from pancreatic carcinoma and neuroendocrine neoplasms are described. The frequency of intrapancreatic metastases in autopsy studies and surgical resection studies will be discussed. Further emphasis is placed on endoscopic ultrasound-guided sampling to confirm the diagnosis.

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“…Surgery has been performed for both primary and metastatic sarcoma arising in the pancreas and duodenum[ 195 , 196 ]. The largest case series describes seven out of 17 existing reports of resection for pancreatic metastases, with one postoperative death and recurrence in all other six cases despite margin-free resection in four cases, with a median survival of 21 mo[ 195 ]. The benefits of resection therefore remain unclear.…”

Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

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Malignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. They may be difficult to differentiate from primary hepato-pancreato-biliary cancer based on imaging studies, or even on biopsy. There is also no consensus on the optimal method of treatment, including the feasibility and effectiveness of endoscopic intervention or surgery. A thorough review of the literature on pancreato-biliary metastases and malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer is presented. The diagnostic modality and clinical characteristics may differ significantly depending on the type of primary cancer. Different primaries also cause malignant biliary obstruction in different ways, including direct invasion, pancreatic or biliary metastasis, hilar lymph node metastasis, liver metastasis, and peritoneal carcinomatosis. Metastasectomy may hold promise for some types of pancreato-biliary metastases. This review aims to elucidate the current knowledge in this area, which has received sparse attention in the past. The aging population, advances in diagnostic imaging, and improved treatment options may lead to an increase in these rare occurrences going forward.

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Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma

Cited by 4 publications

References 27 publications

Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats

Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats

Comments on and Illustrations of the EFSUMB CEUS Guidelines: Transabdominal and Endoscopic Ultrasound Features of Intrapancreatic Metastases and the Role of Multiparametric Imaging and EUS-Guided Sampling in Rare Pancreatic Tumors

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

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