Pancreaticoduodenectomy for metastasis of uterine leiomyosarcoma to the pancreas

Hernandez, Sara M Ricardez; Martín-Fernández, José; Lasa, Inmaculada; Busteros, Ignacio; García-Moreno, Francisca

doi:10.1007/s12094-010-0571-z

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…LMS metastasis to the pancreas is uncommon, and there are few reports. A literature review of LMS metastasis to the pancreas is presented in Table 1 [6][7][8][9][10][11][12][13]. A retrospective study of 13 patients with metastatic pancreatic LMS showed that the median interval between diagnosis of metastases and primary LMS was 24 moths (range, 1-77 moths), and all patients were associated with metastases to other organs [14].…”

Section: Discussionmentioning

confidence: 99%

Recurrent broad ligament leiomyosarcoma with pancreatic and thigh metastasis: a case report

Tian

Yan

et al. 2020

BMC Surg

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Background: Leiomyosarcoma (LMS) is an uncommon mesenchymal neoplasm, which infrequently metastasizes to pancreas and thigh. Clinical presentation and imaging findings of metastatic broad ligament LMS are often nonspecific. Complete excision plays an important role in treatment of patients with localized LMS. Case presentation: Here, we report a case of a 33-year-old woman with recurrent broad ligament LMS metastasizing to pancreas and thigh. Previously, she was diagnosed with broad ligament LMS and underwent hysterectomy, bilateral salpingo-oophorectomy. The disease-free interval was 2.5 years until metastases were found. Computerized tomography (CT) of abdomen and thighs, magnetic resonance imaging (MRI) of thighs and whole-body 18-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) performed, revealed pancreatic and thigh metastasis. Ultrasonography-guided biopsy and histological examinations confirmed LMS at both the sites. Pancreatic metastasis was completely resected first. Then the patient underwent surgical resection of thigh metastasis when both chemotherapy and radiotherapy failed. She recovered well and remained free of disease recurrence in the 2 years follow-up. Conclusions: Though imaging lacks specificity, it is a valuable asset in assessing the burden of disease and characterizing lesions while histological examination with immunohistochemistry is helpful for the diagnosis of LMS. Complete surgical resection of all metastatic sites where-ever feasible should be strongly considered in a treated case of broad ligament LMS with a durable disease-free interval.

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Section: Discussionmentioning

confidence: 99%

Recurrent broad ligament leiomyosarcoma with pancreatic and thigh metastasis: a case report

Tian

Yan

et al. 2020

BMC Surg

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“…Being a rare disease entity, the imaging features of pancreatic metastasis from LMS have not been reported so far. The available literature focuses on management [12,13] and are small series of case reports [810] . Accordingly, the purpose of this article is to describe the multidetector computed tomography (MDCT) features of pancreatic metastasis from LMS.…”

Section: Introductionmentioning

confidence: 99%

Multidetector computed tomography features of pancreatic metastases from leiomyosarcoma: Experience at a tertiary cancer center

Suh

Keraliya

Shinagare

et al. 2016

WJR

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AIM:To describe the multidetector computed tomography features of pancreatic metastasis from leiomyosarcoma (LMS). METHODS:Between January 1995 and December 2012, 13 consecutive patients (11 women, 2 men; mean age of 57 years; range, 38-78 years) with pancreatic metastases from LMS were included in our study. Imaging features including location, number, largest dimension, tumor attenuation and enhancement characteristics, presence of necrosis, pancreatic ductal dilatation, common bile duct (CBD) dilatation, presence of pancreatitis, and atrophy were documented. RESULTS:The most common site of origin of the pancreatic metastases from LMS was uterus (38.5%), followed by retroperitoneum (30.8%) and extremity (23.1%). None of the patients in our study had pancreas as the first site of metastasis. All patients developed pancreatic metastases at a median interval of 24 mo. Pancreatic metastases from LMS were solitary in 8/13 patients and multiple in 5/13 patients, had no predilection for any part of the pancreas, were hypovascular on arterial phase in 10/13 patients and associated with pancreatic duct dilatation in 3/13 patients. None had CBD dilatation. None of the pancreatic metastases in LMS cohort caused pancreatitis, and atrophy. Median duration of follow-up was 19 mo for LMS cohort during which two patients underwent resection of metastasis (median survival 45 mo) while the remaining underwent systemic therapy (median survival 13 mo). ORIGINAL ARTICLE CONCLUSION:Pancreatic metastases from LMS are often solitary and hypovascular masses and less commonly associated with pancreatic ductal dilatation, CBD dilatation, pancreatitis or pancreatic atrophy. Surgical resection of solitary LMS pancreatic metastasis can be considered due to the long survival of these patients. Core tip: Pancreatic metastases from leiomyosarcoma (LMS) commonly arise in the uterus and are characterized by a long latency period after the diagnosis of primary tumor. Although the imaging features of the pancreatic metastases from LMS are nonspecific, pancreatic metastases from LMS should be considered in the differential diagnosis of solitary or multiple hypovascular masses without pancreatic ductal dilatation, common bile duct dilatation, pancreatitis, atrophy in the pancreas in patients with history of LMS. Surgical resection of solitary LMS pancreatic metastasis can be considered due to the long survival of these patients after detection of pancreatic metastasis.Suh CH, Keraliya A, Shinagare AB, Kim KW, Ramaiya NH, Tirumani SH. Multidetector computed tomography features of pancreatic metastases from leiomyosarcoma: Experience at a tertiary cancer center.

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“…However, the literature relating to pancreatic metastases of sarcoma is limited to case studies and two small series. A PubMed search retrieved 17 case reports (6,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). These included three case series, one consisting of four patients, and the other two reported two patients each.…”

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confidence: 99%

Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma

et al. 2018

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Pancreaticoduodenectomy for metastasis of uterine leiomyosarcoma to the pancreas

Cited by 8 publications

References 12 publications

Recurrent broad ligament leiomyosarcoma with pancreatic and thigh metastasis: a case report

Recurrent broad ligament leiomyosarcoma with pancreatic and thigh metastasis: a case report

Multidetector computed tomography features of pancreatic metastases from leiomyosarcoma: Experience at a tertiary cancer center

Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma

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