Pancreatic Polypeptide and Insulin‐Secreting Tumor in a Dog With Duodenal Ulcers and Hypertrophic Gastritis

Zerbe, C. A.; Boosinger, T. R.; Grabau, John H.; Pletcher, J. M.; O'Dorisio, Thomas M.

doi:10.1111/j.1939-1676.1989.tb03095.x

Cited by 11 publications

(12 citation statements)

References 20 publications

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“…7,22 Chronic hypertrophic gastritis and polyps also have mucosal layer thickening although the thickening is predominantly because of mucosal hypertrophy and not edema. 8,9,13 The normal mucosal layer with abnormal In conclusion, the ultrasonographic gastric wall thickening in dogs with clinical acute pancreatitis is presumably because of gastric wall submucosal edema with or without involvement of the muscularis layer, and with preservation of the mucosal layer. Resolution of gastric wall thickening can be observed with positive response to treatment of acute pancreatitis.…”

Section: Discussionmentioning

confidence: 89%

“…SonoCT system, Phillips Ultrasound, Bothell, Washington). A linear array (5)(6)(7)(8)(9)(10)(11)(12) or microconvex array (5-8 MHz) transducer was used. Ultrasonographic evidence of pancreatitis was characterized as the presence of enlarged, irregularly marginated, hypoechoic pancreas and hyperechoic peripancreatic mesenteric fat, as previously described.…”

Section: Case Selectionmentioning

confidence: 99%

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Ultrasonographic features of presumed gastric wall edema in 14 dogs with pancreatitis

Murakami

Heng

Lim

et al. 2019

Veterinary Internal Medicne

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Background Gastric wall edema has not been reported as a complication of acute pancreatitis in dogs. Objective To describe the ultrasonographic features of gastric wall thickening in dogs with acute pancreatitis. Animals Fourteen dogs with ultrasonographic evidence and clinical diagnosis of acute pancreatitis, with ultrasonographic evidence of increased gastric wall thickness (>5 mm). Methods A retrospective search in the medical records from 2014 to 2016 was performed to identify dogs that had ultrasonographic evidence of acute pancreatitis, that had increased thickness of the gastric wall and that were diagnosed with acute pancreatitis clinically. The gastric wall changes such as thickness, layering appearance, echogenicity, distribution of lesions, and perigastric changes were recorded. Serial ultrasonographic examination and histopathological findings were recorded if available. Results Mean gastric wall thickness was 9.9 ± 4.0 mm (SD). A complete loss of wall layering was observed in 2 dogs. Thickening of the submucosal layer was observed in 12 dogs, and 5 of them had concurrent muscularis layer thickening. The echogenicity of thickened submucosal layer was intermediate hyperechoic. Lacy appearances were present within the thickened submucosal layer in 7 dogs and in the muscularis layer of 1 dog. Thickening was focal in 12 dogs and adjacent to the diseased pancreas. Subsequent resolution of gastric wall thickening was observed in 3 dogs (range 3‐28 days) via follow‐up ultrasound. One dog underwent necropsy, and gastric wall edema was confirmed histopathologically. Conclusions and Clinical Importance Findings indicated that gastric wall thickening presumably because of edema could be a complication of acute pancreatitis.

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Section: Discussionmentioning

confidence: 89%

Section: Case Selectionmentioning

confidence: 99%

Ultrasonographic features of presumed gastric wall edema in 14 dogs with pancreatitis

Murakami

Heng

Lim

et al. 2019

Veterinary Internal Medicne

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“…Gastrointestinal Helicobacter-like organisms may have been the underlying cause of the gastritis, but a cause and effect relationship between these bacteria and clinical signs is arguable. 11 Although gastrointestinal ulceration was not detected, unlike in the previously described case, 12,13 the possibility that PP contributed to the vomiting cannot be excluded. Hormone levels were not evaluated in this patient owing to lack of an appropriate specimen.…”

Section: Discussionmentioning

confidence: 59%

CASE REPORT: Metastatic pancreatic polypeptide-secreting islet cell tumor in a dog

Cardona

Wamsley

Farina

et al. 2010

Veterinary Clinical Pathology

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A 14-year-old female spayed Golden Retriever was presented to the University of Florida's Veterinary Medical Center with history of lymphoplasmacytic gastroenteritis, intermittent vomiting, watery diarrhea, and weight loss for over a year. CBC, biochemical profile, and urinalysis were within reference intervals. Abdominal ultrasonographic examination revealed mesenteric and jejunal lymphadenopathy and hyperechoic hepatic nodules. Cytologic examination of the enlarged lymph nodes revealed loosely cohesive cells with moderate nuclear pleomorphism and rare punctate eosinophilic cytoplasmic granules. The cytologic interpretation was metastatic neuroendocrine neoplasia. On surgical exploration, a mass was detected in the right lobe of the pancreas. Histologic evaluation determined the mass to be an islet cell tumor. Approximately 98% of cells were positive by immunolabeling for pancreatic polypeptide (PP), and only rare cells were positive for insulin or somatostatin. All cells were negative for glucagon, gastrin, vasoactive intestinal polypeptide, protein gene product 9.5, synaptophysin, and chromogranins A and B. Pancreatic tumors that primarily produce PP are rare in dogs, and this is the first report of both the cytologic and histologic features of an islet cell tumor predominantly secreting PP. Clinical signs for these tumors are typically absent or nonspecific; signs may include watery diarrhea, as noted in this dog, although the diarrhea may have resulted from lymphoplasmacytic gastroenteritis. Additional case studies are needed to further characterize the cytomorphologic features and clinical presentation of PP-secreting islet cell tumor, or polypeptidoma, in dogs.

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“…">Associated paraneoplastic syndromes (e.g. mastocytoma, APUDoma) (O'Keefe and others 1987 [4c], Zerbe and others 1989 [4c]). The treatment (surgery, radiotherapy and, most importantly, chemotherapy) (Gylys and others 1979 [2b]).…”

Section: Cancer Chemotherapy and Emesismentioning

confidence: 99%

“…Associated paraneoplastic syndromes (e.g. mastocytoma, APUDoma) (O'Keefe and others 1987 [4c], Zerbe and others 1989 [4c]).…”

Section: Cancer Chemotherapy and Emesismentioning

confidence: 99%

Emesis in dogs: a review

Elwood¹,

Devauchelle

Elliott

et al. 2009

J of Small Animal Practice

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Emesis is a common presenting sign in small animal practice. It requires a rational approach to management that is based upon a sound understanding of pathophysiology combined with logical decision making. This review, which assesses the weight of available evidence, outlines the physiology of the vomiting reflex, causes of emesis, the consequences of emesis and the approach to clinical management of the vomiting dog. The applicability of diagnostic testing modalities and the merit of traditional approaches to management, such as dietary changes, are discussed. The role and usefulness of both traditional and novel anti‐emetic drugs is examined, including in specific circumstances such as following cytotoxic drug treatment. The review also examines areas in which common clinical practice is not necessarily supported by objective evidence and, as such, highlights questions worthy of further clinical research.

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Pancreatic Polypeptide and Insulin‐Secreting Tumor in a Dog With Duodenal Ulcers and Hypertrophic Gastritis

Cited by 11 publications

References 20 publications

Ultrasonographic features of presumed gastric wall edema in 14 dogs with pancreatitis

Ultrasonographic features of presumed gastric wall edema in 14 dogs with pancreatitis

CASE REPORT: Metastatic pancreatic polypeptide-secreting islet cell tumor in a dog

Emesis in dogs: a review

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