Pancreatic lipase inhibition of strictinin isolated from Pu’er tea (Cammelia sinensis) and its anti-obesity effects in C57BL6 mice

Chen, Tzu-Yin; Wang, Miki M. C.; Hsieh, Sheng-Kuo; Hsieh, Meng-Huang; Chen, Wenying; Tzen, Jason T. C.

doi:10.1016/j.jff.2018.06.020

Cited by 40 publications

(21 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In flavonoids, proanthocyanidins have been studied extensively with regard to pancreatic lipase inhibition as well as obesity‐mediated complications. Tea polyphenols are enriched with proanthocyanidins and epidemiological studies evidence that they promote the reduction of body weight by decreased fat absorption, adipocyte lipogenesis, and increased fat oxidation (Chen et al, ; Grove & Lambert, ; Huang et al, ). In the present study, we examined the TPC in various legumes, and the maximum level was observed with Vigna unguiculata .…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, hundreds of extracts are now being isolated from plants and microbes and screened for their potential inhibition of pancreatic lipase activity. Also, natural foodstuff such as tea, soybean, citrus, berries, seaweeds, peanut, and apple have also been reported for the inhibition of pancreatic lipase activity (Buchholz & Melzig, ; Chen et al, ). However, the active compound and its mechanism of action are yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cyanidin and cyanidin-3-glucoside derived from Vigna unguiculata act as noncompetitive inhibitors of pancreatic lipase

2019

View full text Add to dashboard Cite

The consumption of legumes positively correlated with the reduction of body weight. In the present study, we identified and evaluated pancreatic lipase inhibitors from Vigna unguiculata and unraveled their mode of inhibition. The highly sensitive fluorometric method was adopted to access the pancreatic lipase activity and the ethanolic extract of Vigna unguiculata showed the maximum inhibition (IC50 of 15.2 µg/ml). Cyanidin and cyanidin‐3‐glucoside are the major anthocyanins observed in Vigna unguiculata. The IC50 value of cyanidin was 28.29 µM which was 6.5‐fold higher than the cyanidin‐3‐glucoside (188.28 µM). We determined an apparent Ki of 27.28 µM for cyanidin and cyanidin‐3‐glucoside (88.97 µM) with noncompetitive inhibition. Collectively, these results suggest that the glycosylation of the anthocyanidins significantly reduces lipase inhibition. The noncompetitive inhibition of pancreatic lipase by Vigna unguiculata anthocyanins may exert significant pharmacological activities toward obesity complications by calorie restriction. Practical applications The results of this study emphasize the importance of legumes in our diet to combat obesity‐related complications. Consumption of legumes minimizes fat absorption by inhibiting the action of the fat‐digesting enzyme.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cyanidin and cyanidin-3-glucoside derived from Vigna unguiculata act as noncompetitive inhibitors of pancreatic lipase

2019

View full text Add to dashboard Cite

show abstract

“…21 Pu-erh tea can lower hyperlipidemia, improve hepatosteatosis and insulin resistance, and has anti-obesity and other beneficial effects. 22–26…”

Section: Introductionmentioning

confidence: 99%

Theabrownin-targeted regulation of intestinal microorganisms to improve glucose and lipid metabolism in Goto-Kakizaki rats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Moreover, the results obtained in a long-term study conducted on mice fed with high-fat and given 130 mg/kg of 3 showed a significant reduction in fat accumulation and their gained body weight. Correspondingly, epididymal fat weight and levels of blood triacylglyceride, cholesterol, and glucose were reduced when strictinin (3) was supplemented (Chen et al 2018).…”

Section: Polyphenolsmentioning

confidence: 97%

Plant Products and Their Inhibitory Activity Against Pancreatic Lipase

Bajes

Almasri

Bustanji

2020

Rev. Bras. Farmacogn.

View full text Add to dashboard Cite

Imbalance in metabolism can lead to many health complications, and obesity is one of the alarming ones in the new world. Modern lifestyle has reduced physical activity and increased intake of various processed, unhealthy, fattening, and fast food. Many approaches have been followed to reduce lipid absorption through the gastrointestinal tract, including herbal plants and drugs. However, due to the side effects associated with drugs, more researches have been navigating towards the discovery of natural substances to substitute synthetic ones. Natural substances have been isolated and identified to inhibit pancreatic lipase, a key enzyme of lipid metabolism; however, only a few have been tested in clinical studies. The aim of this review is to provide relevant information on natural substances derived from plants and algae that have the potential to be anti-obesity agents, with attention to some medicinal plants from Jordan. As a consequence of the information presented in this mini review, several natural compounds have demonstrated to reduce lipid metabolism and absorption, which makes them potential anti-obesity agents.

show abstract

Pancreatic lipase inhibition of strictinin isolated from Pu’er tea (Cammelia sinensis) and its anti-obesity effects in C57BL6 mice

Cited by 40 publications

References 35 publications

Cyanidin and cyanidin-3-glucoside derived from Vigna unguiculata act as noncompetitive inhibitors of pancreatic lipase

Cyanidin and cyanidin-3-glucoside derived from Vigna unguiculata act as noncompetitive inhibitors of pancreatic lipase

Theabrownin-targeted regulation of intestinal microorganisms to improve glucose and lipid metabolism in Goto-Kakizaki rats

Plant Products and Their Inhibitory Activity Against Pancreatic Lipase

Contact Info

Product

Resources

About