Pancreatic islet xenotransplantation

O’Connell, Philip J.

doi:10.1034/j.1399-3089.2002.02056_1.x

Cited by 13 publications

References 47 publications

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3D Cell Culture: A Review of Current Approaches and Techniques

Haycock

2010

Methods in Molecular Biology

449

338

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Cell culture in two dimensions has been routinely and diligently undertaken in thousands of laboratories worldwide for the past four decades. However, the culture of cells in two dimensions is arguably primitive and does not reproduce the anatomy or physiology of a tissue for informative or useful study. Creating a third dimension for cell culture is clearly more relevant, but requires a multidisciplinary approach and multidisciplinary expertise. When entering the third dimension, investigators need to consider the design of scaffolds for supporting the organisation of cells or the use of bioreactors for controlling nutrient and waste product exchange. As 3D culture systems become more mature and relevant to human and animal physiology, the ability to design and develop co-cultures becomes possible as does the ability to integrate stem cells. The primary objectives for developing 3D cell culture systems vary widely - and range from engineering tissues for clinical delivery through to the development of models for drug screening. The intention of this review is to provide a general overview of the common approaches and techniques for designing 3D culture models.

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3D Cell Culture: A Review of Current Approaches and Techniques

Haycock

2010

Methods in Molecular Biology

449

338

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Tissue engineering: current state and perspectives

Lavik

Langer

2004

Appl Microbiol Biotechnol

304

193

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Tissue engineering is an interdisciplinary field that involves cell biology, materials science, reactor engineering, and clinical research with the goal of creating new tissues and organs. Significant advances in tissue engineering have been made through improving singular aspects within the overall approach, e.g., materials design, reactor design, or cell source. Increasingly, however, advances are being made by combining several areas to create environments which promote the development of new tissues whose properties more closely match their native counterparts. This approach does not seek to reproduce all the complexities involved in development, but rather seeks to promote an environment which permits the native capacity of cells to integrate, differentiate, and develop new tissues. Progenitors and stem cells will play a critical role in understanding and developing new engineered tissues as part of this approach.

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In vitro-generation of surrogate islets from adult stem cells

Peck

Ramiya

2004

Transplant Immunology

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Pancreatic islet xenotransplantation

Cited by 13 publications

References 47 publications

3D Cell Culture: A Review of Current Approaches and Techniques

3D Cell Culture: A Review of Current Approaches and Techniques

Tissue engineering: current state and perspectives

In vitro-generation of surrogate islets from adult stem cells

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