Pancreatic ductal system obstruction and acute recurrent pancreatitis

Delhaye, Myriam; Matos, Celso; Arvanitakis, Marianna; Devière, Jacques

doi:10.3748/wjg.14.1027

Cited by 37 publications

(29 citation statements)

References 45 publications

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“…We conclude that PD does not cause subclinical pancreatitis. This corresponds with findings of previous reports that only 5–10% of patients with PD become symptomatic 1 27…”

Section: Discussionsupporting

confidence: 93%

“…The almost perfect consistency between the radiologists in the present study emphasises that MRCP is highly reproducible in diagnosing PD. Secretin enhanced MRCP is reported to improve visualisation of ductal anomalies,26 but abnormal responses of the main pancreatic duct to secreting stimulation were detected in 12% of patients with acute recurrent pancreatitis 27…”

Section: Discussionmentioning

confidence: 99%

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Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey

Gonoi

Akai

Hagiwara

et al. 2011

Gut

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“…We conclude that PD does not cause subclinical pancreatitis. This corresponds with findings of previous reports that only 5–10% of patients with PD become symptomatic 1 27…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey

Gonoi

Akai

Hagiwara

et al. 2011

Gut

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“…Therefore, the indications for and the true response to minor papillotomy remain unclear in clinical practice. Two new studies [11•, 52•], an editorial [53], and a recent review article [54] highlight these issues.…”

Section: Endoscopic and Surgical Therapy For Ip And Pdmentioning

confidence: 99%

Pancreas Divisum

DiMagno

Wamsteker

2011

Curr Gastroenterol Rep

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We review important new clinical observations in pancreas divisum (PD) made since 2007. PD is common and has the same prevalence in the general population and idiopathic pancreatitis (IP). Up to 53% of patients with PD and IP have underlying idiopathic chronic pancreatitis (CP), and in rigorous prospective clinical follow-up and/or natural history studies, many with idiopathic recurrent acute pancreatitis (IRAP) have idiopathic CP. According to retrospective studies, PD does not modify the natural course of nonalcoholic or alcoholic CP. CFTR and/or SPINK1 gene mutations associate with IP (idiopathic CP and IRAP) independently of the presence of PD. More than one third of patients with pancreatitis or presumed pancreaticobiliary pain respond to placebo. Authors of uncontrolled studies report a significant symptomatic response to surgery and endotherapy in patients with IP and PD, but the response remains unproven and is largely limited to those with IRAP and not idiopathic CP or chronic pain.

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“…They can also be associated with recurrent pancreatitis presumably caused by obstructed ductal flow [12]. The most common pancreatic ductal anomaly is pancreas divisum [13]. Divisum is caused by failure of gestational fusion of the dorsal and ventral endodermal buds.…”

Section: Congenital Anomaliesmentioning

confidence: 99%

Pancreatic Disease in Children and Adolescents

Jolley

2010

Curr Gastroenterol Rep

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Many childhood pancreatic disorders are rare, although they can represent significant and potentially severe disease. The spectrum of disease is very broad, ranging from the complex and bizarre congenital anomalies to the more typical acquired causes (e.g., drug-induced pancreatitis or trauma injury). Genetics appears to play a major role in many childhood pancreas diseases, unlike adults where alcohol is a major factor. Nevertheless, there are similarities, and most of the disorders discussed here can be found in both the pediatric and adult age groups. Some of these disorders may be evolving and may be seen in both young and older patients. Newer imaging modalities and therapeutic endoscopy continue to be studied, although their ultimate role and utility in children has yet to be fully elucidated.

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Pancreatic ductal system obstruction and acute recurrent pancreatitis

Cited by 37 publications

References 45 publications

Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey

Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey

Pancreas Divisum

Pancreatic Disease in Children and Adolescents

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