Pancreatic carcinoma: results with fast neutron therapy

Kaul, Raman; Cohen, Lionel; Hendrickson, Frank R.; Awschalom, M.; Hrejśa, Allen F.; Rosenberg, Ivan

doi:10.1016/0360-3016(81)90433-8

Cited by 26 publications

(2 citation statements)

References 3 publications

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“…At the Fermi National Accelerator Laboratory, 50 patients were treated for advanced pancreatic carcinoma with a fast neutron beam [17]. All patients had histologically confirmed cancer.…”

Section: Particle Beam Therapymentioning

confidence: 99%

Treatment of pancreatic cancer by radiation therapy

Dobelbower

Milligan

1984

World j. surg.

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The role of radiation therapy in the management of pancreatic malignancy was expanded dramatically in the last decade. Development of new tumor localization and dose delivery techniques permits safe delivery of increased radiation dose to upper abdominal tumors. Interstitial implantation of radioisotopes directly into tumors has increased the local control rate for pancreatic cancer as high as 80%, but the perioperative mortality rate of this procedure is as high as 25%, except in highly controlled situations. Early data from the high linear energy transfer (LET) treatment programs suggest higher than expected complication rates, yet survival seems no better than that reported from precision high‐dose (PHD) external beam regimens. Radiation as an adjuvant to surgery has been inadequately tested, but initial reports from preoperative and postoperative trials are encouraging. Intraoperative irradiation poses theoretical advantages over external beam therapy for pancreatic cancer. Chemotherapy seems an effective adjuvant to external beam radiation therapy for pancreatic cancer. Drugs other than 5‐FU have not been adequately evaluated in adjuvant studies, nor have newer radiation treatment methods been fully evaluated in combination with drugs.

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“…At the Fermi National Accelerator Laboratory, 50 patients were treated for advanced pancreatic carcinoma with a fast neutron beam [17]. All patients had histologically confirmed cancer.…”

Section: Particle Beam Therapymentioning

confidence: 99%

Treatment of pancreatic cancer by radiation therapy

Dobelbower

Milligan

1984

World j. surg.

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“…Reprint requests: William U. Shipley, M.D., The Radiation Medicine and General Surgical Services, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, U.S.A. irradiation by particle beams (neutrons or helium ions) [2][3][4]. Thus, radiation therapists and their surgical colleagues have used intraoperative radiation therapy (IORT) as a method to deliver safely higher radiation doses to the pancreatic tumors than are possible with external beam techniques.…”

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confidence: 99%

Intraoperative radiation therapy for patients with pancreatic carcinoma

et al. 1984

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The results of treatment with intraoperative and external beam radiation for patients with carcinoma of the pancreas are presented. Among patients treated with125I implants for localized unresectable disease, local control rates ranged from 67% to 93% and median survival ranged from 7 to 12 months. In a series using intraoperative electron beam boosts, a 59% local control rate with a median survival of 16 months was achieved. Good palliation rates were achieved, although a high proportion of fatal complications occurred in one125I series. Less promising results were seen in patients receiving intraoperative radiation following resections, with a local control rate of 50% and a median survival of 7 months in a series of 10 patients.

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Multimodality therapy of localized unresectable pancreatic adenocarcinoma

Whittington

Solin

Mohiuddin

et al. 1984

Cancer

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Eighty‐eight patients with localized unresectable carcinoma of the pancreas were treated at Thomas Jefferson University Hospital between 1974 and 1981. Four treatment regimens were used which were sequential modifications of the technique based on the experience in the preceeding group of patients. Each treatment changed the course of the disease, and as patterns of failure were identified, the treatment was altered to deal with them. Initially, all patients were treated with external beam radiation. Subsequently, Iodine‐125 implantation was added to improve local control; low‐dose preoperative radiotherapy to reduce the risk of peritoneal seeding; and adjuvant chemotherapy to reduce the risks of distant metastases. The addition of 125I implantation increased the local control from 22% to 81%, but did not increase the median survival, which was unchanged from 7 months. The addition of adjuvant chemotherapy increased the median survival from 7 months to 14 months, but had no impact on the control of the pancreatic tumor. Adjunctive chemotherapy and low‐dose preoperative radiotherapy appear synergistic in reducing the risk of peritoneal seeding. The combination of 125I implantation, external beam radiation, and adjunctive chemotherapy is safe and effective. This regimen produces excellent local control with acceptable morbidity. This regimen produced a 30% survival at 18 months. The patterns of failure among these patients suggest future modifications of the technique.

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Pancreatic carcinoma: results with fast neutron therapy

Cited by 26 publications

References 3 publications

Treatment of pancreatic cancer by radiation therapy

Treatment of pancreatic cancer by radiation therapy

Intraoperative radiation therapy for patients with pancreatic carcinoma

Multimodality therapy of localized unresectable pancreatic adenocarcinoma

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