Pancreatic blood flow in conscious dogs after oral administration of glucose

Fischer, Uwe; Hommel, H; Salzsieder, E

doi:10.1007/bf00428978

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…Early attempts to investigate the islet microcirculation with intravital microscopy suggested that wide variations occur in the blood flow to the islets, which seemed related to the functional state of the B cells [1,4,5,28]. More recent studies indicate that blood flow to the whole pancreas may increase under conditions which stimulate insulin release [6,7,33], but these observations have been difficult to interpret, since the endocrine and exocrine parts of the gland may not share the same mechanisms for regulating blood flow [35].…”

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Stimulation by glucose of the blood flow to the pancreatic islets of the rat

1983

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Blood flow to the pancreatic islets of the rat was estimated with the microsphere technique. Experiments with microspheres of different sizes (diameter 10, 15 or 50 micron) showed that optimal results were obtained with 10-micron spheres. Localization of microspheres either within or outside the islets was accomplished by freeze-thawing of the pancreas, making it transparent, so that both islets and microspheres could be distinguished in dark field illumination. Thus, microscopic examination of the freeze-thawed pancreas allowed the microspheres to be counted separately in both the endocrine and exocrine parenchyma. Under basal conditions, pancreatic blood flow was calculated as 0.60 ml X min-1 X g-1 (w/w). The islets accounted for about 10% of the total pancreatic blood flow, corresponding to 0.069 ml/min per whole pancreas. A bolus dose of glucose increased pancreatic blood flow to 0.75 ml X min-1 X g-1 (p less than 0.05), while the fractional islet blood flow rose to 15.1% (p less than 0.001) corresponding to 0.125 ml X min-1 X pancreas-1 (p less than 0.001). The glucose-induced increase in pancreatic blood flow mainly resulted from increased flow to the pancreatic tail, while the corresponding increase in islet blood flow was uniformly distributed throughout the pancreas. Injection of the non-metabolizable glucose-derivate. 3-0-methyl-D-glucose, affected neither the pancreatic nor the islet blood flow. The data indicate that the islets receive more of the pancreatic blood flow than would be accounted for by their relative volume and that glucose preferentially stimulates blood flow to the islets.

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confidence: 99%

Stimulation by glucose of the blood flow to the pancreatic islets of the rat

1983

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Circulation of the pancreas and salivary glands

Kvietys

Granger

Harper

1989

Comprehensive Physiology

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Pancreatic blood flow in hemorrhagic shock

et al. 1980

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Pancretic blood flow rates were determined using a 133Xe washout technique in a total of 40 dogs, 14 of which were used as a control group and the remaining 26 as the experimental group. The initial pancreatic blood flow rates of control group and of the experimerntal group were 85.1 +/- 10.1 ml/100 g/min of pancreas/min and 81.1 +/- 5.4 ml/100 g/min respectively. These values were not significantly different from each other (P > 0.05). In the control group the blood flow was determined 3 times at 30 min intervals. These mean values were 73.0 +/- 9.4, 74.6 +/- 8.7, and 79.4 +/- 10.4 m/100 g/min respectively (P > 0.05). The dogs in the experimental group were bled and the peripheral arterial blood pressure was reduced stepwise to 80, 50, and 30 mm Hg. At each level at 30 min of stabilization period the pancreatic blood flow rates were 49.8 +/- 3.7, 29.3 +/- 2.3 and 20.2 +/- 2.3 ml/100 g/min respectively. These mean values were very significantly reduced compared to those of the control group at 30 min (P < 0.02), at 60 and 90 min (P > 0.001). They were also very significantly different from their own initial values (P < 0.001). The metabolic consequences of this reduction in pancreatic blood flow are discussed.

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Pancreatic blood flow in conscious dogs after oral administration of glucose

Cited by 9 publications

References 20 publications

Stimulation by glucose of the blood flow to the pancreatic islets of the rat

Stimulation by glucose of the blood flow to the pancreatic islets of the rat

Circulation of the pancreas and salivary glands

Pancreatic blood flow in hemorrhagic shock

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