Circulation of the pancreas and salivary glands

Kvietys, Peter R.; Granger, D. Neil; Harper, S. L.

doi:10.1002/cphy.cp060142

Cited by 5 publications

(5 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Measurements of pancreatic perfusion in animals vary depending upon species and technique used with a range of 0.35-1.73 ml m i n i m i " 1 with no variation in perfusion between the head, body and tail [11]. Excluding the single high reading in the patient with Wilson's disease, the CT results derived from normal human pancreases are entirely in accordance with these values.…”

Section: Vol 68 No 809 K a Miles M P Hayball And A K Dixonmentioning

confidence: 53%

Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging

Miles¹,

Hayball²,

Dixon³

1995

The British Journal of Radiology

View full text Add to dashboard Cite

Absolute quantification of pancreatic perfusion in man has been extremely difficult to date. This paper describes a relatively simple application of dynamic computed tomography to provide perfusion imaging of the human pancreas. Values for perfusion in eight normal pancreases ranged between 1.25 and 1.66 ml min-1 ml-1 (mean: 1.52 ml min-1 ml-1). Increased perfusion values were present in a patient with an islet cell tumour (overall perfusion 2.11 ml min-1 ml-1) and a patient with Wilson's disease (3.43 ml min-1 ml-1). Pancreatic perfusion was reduced in a patient with diabetes (0.60 ml min-1 ml-1) and in a failing pancreatic transplant (0.97 ml min-1 ml-1). The combination of functional information and good spatial detail afforded by computed tomography (CT) perfusion imaging means the technique is well suited for the evaluation of the human pancreas. It is currently the only technique which allows non-invasive absolute quantification of pancreatic perfusion.

show abstract

Section: Vol 68 No 809 K a Miles M P Hayball And A K Dixonmentioning

confidence: 53%

Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging

Miles¹,

Hayball²,

Dixon³

1995

The British Journal of Radiology

View full text Add to dashboard Cite

show abstract

“…Pancreatic tissue O 2 tension decreased when secretion was stimulated by CCK-8 (9). A direct linear relationship between the rate of exocrine secretion and O 2 consumption has been demonstrated in the salivary gland and pancreas, and the magnitude of the functional hyperemia is proportional to the increment in O 2 consumption (18). Thus a linear relationship between pancreatic protein secretion and blood flow (Fig.…”

Section: G617mentioning

confidence: 72%

“…A number of possible mediators have been proposed for CCK-induced hyperemia (11,12,18,24), but it is not exactly known how CCK induces pancreatic vasodilatation. There is evidence for specific binding sites of CCK-33 in the rat vascular endothelium, especially in the pancreatic islets but to a lesser extent in the exocrine pancreas (27).…”

Section: G617mentioning

confidence: 99%

“…PANCREATIC BLOOD FLOW INCREASES after an ingestion of a meal (6,13). Postprandial pancreatic hyperemia results from the complex interplay of both intrinsic (tissue metabolism) and extrinsic factors (neurohumoral regulators) as well as general hemodynamics (18). A physiological contribution of each factor, however, has not been fully clarified yet.…”

mentioning

confidence: 99%

“…Two classic gastrointestinal hormones, secretin and cholecystokinin (CCK), are considered to be the major hormonal regulators of the intestinal phase of pancreatic secre-tion. Their involvement in the regulation of pancreatic circulation has been suggested, because both hormones can increase pancreatic blood flow in anesthetized animals (3,18). However, conclusive evidence is still lacking owing to the anatomical complexities of pancreatic circulation and technical difficulties in pancreatic blood flow measurement in the conscious state.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs

Nakajima

Naruse

Kitagawa

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

The regulatory mechanisms of postprandial pancreatic hyperemia are not well characterized. The aim of this study is to clarify the role of cholecystokinin (CCK) in the intestinal phase of pancreatic circulation. Pancreatic, gastric, and intestinal blood flows were measured by ultrasound transit-time blood flowmeters in five conscious dogs. Pancreatic and gastric secretion and blood pressure were also monitored. Synthetic CCK octapeptide (CCK-8) or gastrin heptadecapeptide (gastrin-17) was infused intravenously, and milk was infused into the duodenum with or without loxiglumide, a specific CCK-A receptor antagonist. CCK-8 induced dose-related increases of pancreatic, but not gastric or intestinal, blood flow and protein secretion without affecting systemic blood pressure. Gastrin-17 did not affect pancreatic blood flow. An intraduodenal infusion of milk increased pancreatic and intestinal blood flows and pancreatic protein secretion. Loxiglumide completely inhibited pancreatic blood flow and protein responses to CCK-8 and milk but not the intestinal blood flow response. CCK is a potent and specific pancreatic vasodilator, with its effect mediated by CCK-A receptors. CCK plays an important role in the regulation of the intestinal phase of the pancreatic circulation in dogs.

show abstract

Effect of glycolysis on pancreatic microcirculation and cellular functions in anesthetized rats

Seiyama

Kosaka

2000

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

It has been reported that aerobic glycolysis in the pancreas contributes less than 10% to oxidative phosphorylation based on in vitro experiments using pancreatic tissue segments. However, its contribution to aerobic glycolysis in vivo remains uncertain. We investigated the effect of inhibiting glycolysis on O2 metabolism in microvessels, exocrine enzyme secretion, and the blood glucose level in the pancreas of anesthetized rats in vivo. Inhibition of glycolysis, by superfusing the pancreas of anesthetized rats with 2-deoxyglucose (10 mM) or sodium fluoride (2 mM), significantly decreased O2 release from erythrocytes flowing in the microvessels by 30-40%. Inhibiting glycolysis did not affect the exocrine secretion of pancreatic juice but decreased the secretion of total protein by approximately or = to 40%. Inhibiting glycolysis decreased blood glucose levels by approximately or = to 40% and increased glucagon release twofold. Aerobic glycolysis may play more important roles in the regulation of O2, metabolism, pancreatic exocrine enzyme secretion and the blood glucose level in rat pancreas.

show abstract

Circulation of the pancreas and salivary glands

Cited by 5 publications

References 158 publications

Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging

Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging

Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs

Effect of glycolysis on pancreatic microcirculation and cellular functions in anesthetized rats

Contact Info

Product

Resources

About