2006
DOI: 10.1002/cncr.21842
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Pancreatic and bile duct brushing cytology in 1000 cases

Abstract: BACKGROUND Duct brushing cytology is an important tool in evaluation of the extrahepatic biliary tract and large pancreatic ducts. The emergence of neoadjuvant therapies underscores the importance of accurate preoperative diagnosis by noninvasive means. Liquid‐based preparation methods, such as ThinPrep, have become popular for nongynecologic cytology specimens. METHODS Findings from bile and pancreatic duct brushings were reviewed over the 10‐year period of 1994‐2003. Cytologic material, imaging reports, and … Show more

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Cited by 150 publications
(53 citation statements)
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“…However, these results have not yielded a high enough sensitivity to be used over serum biomarkers to diagnose pancreatic cancer. 95 Therefore, unless highly specific and sensitive biomarkers are discovered in pancreatic juice, it is currently less useful than serum biomarkers to diagnose pancreatic neoplasms.…”
Section: Challenges In Creating An Effective Screening Testmentioning
confidence: 99%
“…However, these results have not yielded a high enough sensitivity to be used over serum biomarkers to diagnose pancreatic cancer. 95 Therefore, unless highly specific and sensitive biomarkers are discovered in pancreatic juice, it is currently less useful than serum biomarkers to diagnose pancreatic neoplasms.…”
Section: Challenges In Creating An Effective Screening Testmentioning
confidence: 99%
“…Recent development of the endoscopic pancreatic juice cytology, endoscopic brushing cytology or biopsy from the stenotic duct provided histological evidence for pancreatic cancer, but sensitivity was not satisfactory [3]. Based on these circumstances, novel molecular markers which can improve the sensitivity of cytology and biopsy were extensively studied.…”
Section: Introductionmentioning
confidence: 99%
“…Some biomarkers of cells obtained from pancreatic ductal brushing and cytology have been identified. However, they offered little screening sensitivity over serum biomarkers to diagnose pancreatic cancer [34]. The role of positron emission tomography scanning (PET) is still unclear in pancreatic cancer.…”
Section: Screening Toolsmentioning
confidence: 99%