Pancreatic adenosquamous carcinoma with invasion to the spleen in a cat

Abstract

A four-and-a-half-year-old female Scottish Fold cat underwent partial pancreatectomy with en-bloc splenectomy. The resected specimen was a biphasic tumor that was diagnosed histologically and immunohistochemically as pancreatic adenosquamous carcinoma (ASC), a ductal carcinoma variant according to the WHO classification of tumors in humans. There was a gradual transition between the adenocarcinoma component and the squamous cell carcinoma component. The squamous cell carcinoma component comprised approximately 30-40 % of the tumor. A pancreatic tumor infiltrated into the gastrosplenic ligament and spleen with regional lymph node and mesenteric metastases. Pancreatic ASC has not been reported in animals. This is a case report of feline pancreatic ASC with splenic involvement.

Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog

“…One case of pancreatic ASC in a cat has been published. 17 As in this case, canine exocrine pancreatic adenocarcinomas are most commonly diagnosed at exploratory coeliotomy or postmortem examination. 5 10 The clinical prognosis is grave with reported survival times ranging from 1 day to several weeks; a few cases of hyalinising tubular pancreatic carcinoma have been reported with survival over a year.…”

“…While mammary,12 pulmonary13–15 and oesophageal16 ASC have been reported in dogs, pancreatic origin has not. One case of pancreatic ASC in a cat has been published 17…”