Pancreatic Acinar Cell Metaplasia in Autoimmune Gastritis

Jhala, Nirag; Montemór, Mário Rodrigues; Jhala, Darshana; Lin, Li; Talley, Lynya; Haber, Marian M.; Lechago, Juan

doi:10.5858/2003-127-854-pacmia

Cited by 67 publications

(5 citation statements)

References 9 publications

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“…Omeprazole was reported to cause PACM after six months of treatment in rats [17]. In humans, PACM is often observed in patients with autoimmune gastritis [3]. Hypergastrinemia is a shared feature between the oral administration of proton pump inhibitors and autoimmune gastritis; however, we did not nd a relationship between hypergastrinemia and PACM in patients with H. pylori gastritis in the present study.…”

Section: Discussioncontrasting

confidence: 65%

“…Pancreatic acinar cell metaplasia (PACM), which is a rare nding in gastric mucosa (1), comprises clusters of pancreatic acinar cell-like cells that are mainly located in the gastric lamina propria [1]. PACM has been observed in the esophagogastric junction of patients with Barrett's esophagus and in the greater curvature of the gastric corpus in patients with autoimmune gastritis [2,3]. Unlike heterotopic pancreas, PACM lacks pancreatic ducts and islets of Langerhans [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection

Fuchino

Wada

Kodama

et al. 2022

Preprint

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Background:Pancreatic acinar cell metaplasia (PACM) has been rarely reported in the gastric mucosa. In the present study, we aimed to elucidate the clinical and pathological characteristics of PACM associated with Helicobacter pylori (H. pylori).Method6655 patients who underwent two- or five-point gastric biopsy according to the updated Sydney system (USS) by upper gastrointestinal endoscopy were enrolled. The patients were categorized into current H. pylori infection (CHI), post-H. pylori eradication (PHE), and non-H. pylori infection (NHI) groups according to the H. pylori infection status, and the frequency and location of PACM were compared. Additionally, a case-control study was performed to compare the USS scores between patients with CHI and PACM and those with CHI but not PACM. ResultThe frequencies of PACM were 0.49% (10/2039), 0.75% (25/3332), and 0% (0/559) in the CHI, PHE, and NHI groups, respectively. PACM was found in the greater curvature of the antrum in 33 of the 35 patients with PACM. Among the patients with CHI, the inflammation scores in the greater curvature of the antrum and the greater curvature of the corpus were lower in patients with PACM than in those without PACM. ConclusionAlthough rarely reported in the gastric mucosa, PACM was closely related to H. pylori infection, especially in the antrum, and was associated with relatively mild inflammation.

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Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection

Fuchino

Wada

Kodama

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Other report showed that omeprazole was reported to cause PACM after six months of treatment in rats [ 18 ]. In humans, PACM is often observed in patients with autoimmune gastritis [ 3 ]. Hypergastrinemia is a shared feature between the oral administration of PPI and autoimmune gastritis; however, we did not find a relationship between hypergastrinemia and PACM in patients with H. pylori gastritis in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatic acinar cell metaplasia (PACM), which is a rare finding in gastric mucosa, comprises clusters of pancreatic acinar cell-like cells that are mainly located in the gastric lamina propria [ 1 ]. PACM has been observed in the esophagogastric junction of patients with Barrett’s esophagus and in the greater curvature of the gastric corpus in patients with autoimmune gastritis [ 2 , 3 ]. Unlike heterotopic pancreas, PACM lacks pancreatic ducts and islets of Langerhans [ 1 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection

et al. 2022

View full text Add to dashboard Cite

Background Pancreatic acinar cell metaplasia (PACM) has been rarely reported in the gastric mucosa. In the present study, we aimed to elucidate the clinical and pathological characteristics of PACM associated with Helicobacter pylori (H. pylori). Method 5930 patients who underwent five- or two-point gastric biopsy according to the updated Sydney system (USS) by upper gastrointestinal endoscopy were enrolled. The patients were categorized into current H. pylori infection (CHI), post-H. pylori eradication (PHE), and non-H. pylori infection (NHI) groups according to the H. pylori infection status, and the frequency and location of PACM were compared. Additionally, a case–control study was performed to compare the USS scores between patients with CHI and PACM and those with CHI but not PACM. Result The frequencies of PACM were 0.49% (10/2039), 0.75% (25/3332), and 0% (0/559) in the CHI, PHE, and NHI groups, respectively. PACM was found in the greater curvature of the antrum in 33 of the 35 patients with PACM. Among the patients with CHI, the inflammation scores in the greater curvature of the antrum and the greater curvature of the corpus were lower in patients with PACM than in those without PACM. Conclusion Although rarely reported in the gastric mucosa, PACM was closely related to H. pylori infection, especially in the antrum, and was associated with relatively mild inflammation.

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“…In the stomach, pancreatic tissue can be found in two different forms: as HP or as gastric pancreatic metaplasia characterised by nests, lobes or isolated pancreatic cells in gastric mucosa. The latter has been related with autoimmune gastritis [25,26,27].…”

Section: Clinical Casementioning

confidence: 99%

Gastric collision tumour with probable ectopic pancreatic origin

Gonzáles¹,

Arroyo-Gárate²,

Estrella³

et al. 2022

ecancer

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Introduction Mixed histology tumours are rarely found in the stomach. Of these, collision tumours are mainly composed of adenocarcinomas and sarcomas or lymphomas. This is the seventh case reported in the literature of an acinar cell carcinoma arising from an ectopic pancreas located in the stomach and the first described within a collision tumour. Clinical case We present the case of a 58-year-old female patient diagnosed with gastric cancer who, after undergoing a total gastrectomy, presented with a pathology report describing findings compatible with gastric collision tumour with components of tubular adenocarcinoma and acinar cell carcinoma of probable pancreatic ectopic aetiology. Discussion At the beginning of the 20th century, collision tumours were rarely described. Those located in the stomach are an infrequent pathology and are rarely diagnosed preoperatively. A collision tumour is composed of two independent neoplastic tissue with tumour areas separated in two different histological patterns and, in case of metastasis, this separation must also be clearly identified. There are different theories about its carcinogenesis and the debate regarding the ideal treatment is still ongoing. Conclusion This is the first report of a malignant gastric tumour with probable heterotopic pancreatic origin that collides with gastric adenocarcinoma.

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Pancreatic Acinar Cell Metaplasia in Autoimmune Gastritis

Cited by 67 publications

References 9 publications

Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection

Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection

Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection

Gastric collision tumour with probable ectopic pancreatic origin

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