Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis

Xu, Caihui; Li, Teng; Liu, Haiyan; Chen, Gongbin; Guo, Yinmou

doi:10.1039/c9ra07622k

Cited by 4 publications

(1 citation statement)

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“…Several studies on P. notoginseng have concluded that this plant increased the sensitivity of cancer cells to radiation or chemical therapies, so it could be used in combination with these in the treatment of cancer patients. [7][8][9] According to ancient oriental documents, P. notoginseng could decrease the growth of tumors in cancer. According to clinical experience, many patients with fibroids such as in the breast, uterus, and prostate have been treated with P. notoginseng ventricular long-term doses, and the results have found that the tumor sizes were not greatly increased.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice

2021

TJNPR

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In addition, water extracted from P. notoginseng has been confirmed to inhibit human lung carcinoma cells, with the inhibition rate reaching 89%. 13 Several studies have shown that steaming P. notoginseng roots increased the antitumor activity. [14][15][16][17] In Vietnam, P. notoginseng grows wildly and is also grown in the high mountains in the north. However, research to evaluate the effect on tumors of raw or steamed P. notoginseng roots is lacking. The study evaluated and compared the antitumor effects of saponin-rich extracts from steamed and raw P. notoginseng roots collected in Vietnam on Swiss mice bearing solid sarcoma TG 180 tumors. Materials and methods Plant materialThe roots used were from 4-year-old tuberous P. notoginseng (Burk.) F.H. grown in Simacai village, Lao Cai province, in the north of Vietnam. The roots were collected in July 2015 and indentified by Dr.

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Section: Introductionmentioning

confidence: 99%